Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy

Li, Huipeng; Yang, Xue; Gao, Fang; Qian, Chenggen; Li, Chenzi; Oupický, David; Sun, Minjie

doi:10.1016/j.jconrel.2018.02.036

Cited by 36 publications

(25 citation statements)

References 36 publications

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“…Crosslinked nanogels have better stability than micelles and liposomes, which can prevent burst release during circulation, thus improving the tumor accumulation and drug-delivery efficiency. Some nanogels were reported to had higher accumulation in a tumor site compared with other major organs including liver and spleen [ 60 , 74 ], which was seldom reported for micelles and liposomes [ 102 ]. In addition, fluorophores can be easily conjugated onto the surface of nanogels by virtue of their multifunctionality.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, development of environmentally responsive nanogel for tumor-specific gene delivery is in high demand to minimize the side effect of gene therapy. Sun et al designed a disulfide bond containing nanogels which composed of thiolated dextrin and PEI [ 60 ]. PEI in the nanogels can load Bcl2 siRNA, which is an antiapoptosis factor in malignant cells.…”

Section: Crosslinked Nanogels For Cancer Therapymentioning

confidence: 99%

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Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Zhou

Yang

et al. 2020

Polymers

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Nanomaterials have been widely applied in the field of cancer imaging and therapy. However, conventional nanoparticles including micelles and liposomes may suffer the issue of dissociation in the circulation. In contrast, crosslinked nanogels the structures of which are covalently crosslinked have better physiological stability than micelles and liposomes, making them more suitable for cancer theranostics. In this review, we summarize recent advances in crosslinked nanogels for cancer imaging and therapy. The applications of nanogels in drug and gene delivery as well as development of novel cancer therapeutic methods are first introduced, followed by the introduction of applications in optical and multimodal imaging, and imaging-guided cancer therapy. The conclusion and future direction in this field are discussed at the end of this review.

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Section: Discussionmentioning

confidence: 99%

Section: Crosslinked Nanogels For Cancer Therapymentioning

confidence: 99%

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Zhou

Yang

et al. 2020

Polymers

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“…The authors concluded that the longer blood circulation time, as opposed to naked siRNA that was rapidly cleared by liver and kidney, as well as the suitable size of the designed nanoparticles were decisive characteristics leading to the effective tumoral enrichment. [51]…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…injection of the Cy5 siRNA loaded nanogel into 4T1-luc tumor-bearing mice. (Reproduced with permission from [51])…”

Section: Figurementioning

confidence: 99%

Recent progress of polymeric nanogels for gene delivery

Kandil

Merkel

2019

Current Opinion in Colloid & Interface Science

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With its nearly unrestricted possibilities, gene therapy attracts more and more significance in modern-day research. The only issue still seeming to hold back its clinical success is the actual effective delivery of genetic material. Nucleic acids are in general challenging to administer to their intracellular targets due to their unfavorable pharmaceutical characteristics. Polymeric nanogels present a promising delivery platform for oligonucleotide-based therapies, as the growing number of reports deliberated in this review represents. Within the scope of this article, recent progress in the employment of nanogels as gene delivery vectors is summarized and different examples of modified, stimuli-responsive, targeted and co-delivering nanogels are discussed in detail. Furthermore, major aspects of successful gene delivery are addressed and critically debated in regards to nanogels, giving insights into what progress has been made and which key issues still need to be further approached.

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“…Bcl2 family is the central regulators of programmed cell death, and Bcl-2 is a cell survival protein, which has been widely verified as an important factor of inhibiting apoptosis and promoting oncogenesis [ 11 ]. Overexpression of Bcl2 in malignant cells is related to tumour initiation, progression, and therapy resistance in bladder cancer [ [12] , [13] , [14] ]. RNA interference-based post-translational gene silencing with small interfering RNA (siRNA) is capable of gene-specific reduction, and RNAi has been confirmed with a stronger anti-tumour effect in vitro .…”

Section: Introductionmentioning

confidence: 99%

Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

Liang

Wang

et al. 2021

Bioactive Materials

110

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Bladder cancer is one of the concerning malignancies worldwide, which is lacking effective targeted therapy. Gene therapy is a potential approach for bladder cancer treatment. While, a safe and effective targeted gene delivery system is urgently needed for prompting the bladder cancer treatment in vivo . In this study, we confirmed that the bladder cancer had CD44 overexpression and small interfering RNAs (siRNA) with high interfere to Bcl2 oncogene were designed and screened. Then hyaluronic acid dialdehyde (HAD) was prepared in an ethanol-water mixture and covalently conjugated to the chitosan nanoparticles (CS-HAD NPs) to achieve CD44 targeted siRNA delivery. The in vitro and in vivo evaluations indicated that the siRNA-loaded CS-HAD NPs (siRNA@CS-HAD NPs) were approximately 100 nm in size, with improved stability, high siRNA encapsulation efficiency and low cytotoxicity. CS-HAD NPs could target to CD44 receptor and deliver the therapeutic siRNA into T24 bladder cancer cells through a ligand-receptor-mediated targeting mechanism and had a specific accumulation capacity in vivo to interfere the targeted oncogene Bcl2 in bladder cancer. Overall, a CD44 targeted gene delivery system based on natural macromolecules was developed for effective bladder cancer treatment, which could be more conducive to clinical application due to its simple preparation and high biological safety.

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Bioreduction-ruptured nanogel for switch on/off release of Bcl2 siRNA in breast tumor therapy

Cited by 36 publications

References 36 publications

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Recent Advances in Crosslinked Nanogel for Multimodal Imaging and Cancer Therapy

Recent progress of polymeric nanogels for gene delivery

Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer

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