Bioreactivity of a novel poly(epsilon-caprolactone) nanocapsule containing atrazine with human lung alveolar epithelial cells

Moore, Ajs; Dean, Lareb S. N.; Yam, Aiken; Lima, Renata de; Fraceto, Leonardo Fernandes; Tetley, Teresa D.

doi:10.1039/d1en01068a

Cited by 5 publications

(2 citation statements)

References 81 publications

(134 reference statements)

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“…Considering the fact that atrazine is harmful to humans and animals, Moore et al [107] prepared nano-PCL-atrazine and evaluated its effect on human lung cells, as atrazine may reach respiratory units via inhalation. In previous research, it was reported that nano-PCL-atrazine was safer to human cells than atrazine, but, according to the results of this investigation, 48 h after the exposure of cells to nano-PCL-atrazine with concentrations of more than 1 ppm, the dehydrogenase release of lactate notably increased, with a maximum at 5 ppm, which was three times more than the control cells.…”

Section: Atrazine-pcl Nanoherbicidesmentioning

confidence: 99%

“…Such effects were not observed in cells treated with atrazine or PCL nanocapsules. Therefore, nano-PCL-atrazine caused more damage to human lung alveolar cells than atrazine or PCL nanocapsules; however, nanoformulations provide higher herbicidal activity and can be applied at lower dosages, thus causing less ecological contamination [107].…”

Section: Atrazine-pcl Nanoherbicidesmentioning

confidence: 99%

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New Advances in Nano-Enabled Weed Management Using Poly(Epsilon-Caprolactone)-Based Nanoherbicides: A Review

Zargar,

Bayat,

Saquee

et al. 2023

Agriculture

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The number of effective herbicides available to farmers is steadily decreasing due to increasing herbicide resistance. It seems very important to address and effectively deal with the main weed management challenges (low crop yield and environmental pollution) by investigating the potential of newly introduced materials, such as biocompatible polymer-based nanoparticles. The current review aims to encourage agricultural or environmental researchers to conduct new research on the synthesis and application of modified herbicides, such as nanoherbicides, for application in weed management and to provide a comprehensive foundation on the topic. Such nanosystems could help with the promotion of the controlled release of active ingredients and extend their action time, resulting in a reduction in dose and application number; improve the physical and chemical characteristics of the herbicide to increase foliar adhesion; prevent degradation that results from environmental factors (such as sunlight, temperature, microorganisms, or pH); and decrease herbicide leaching and contamination of the environment. Furthermore, it has been indicated that some polymeric nanocarriers can penetrate biological barriers, including membranes and plant cell walls, and translocate across vascular tissues, resulting in a more efficient delivery of active ingredients. Poly(epsilon-caprolactone) is a biocompatible material that is easily decomposable by enzymes and fungi. PCL nanoparticles could be applied as nanocarriers of herbicides in agriculture due to their low toxicity, their potential for large-scale synthesis from inexpensive materials, their ability to dissolve herbicides, their high loading capacity, and their ability to help minimize the chemical decomposition of herbicides.

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Section: Atrazine-pcl Nanoherbicidesmentioning

confidence: 99%

Section: Atrazine-pcl Nanoherbicidesmentioning

confidence: 99%