Biopsychosocial frailty and mild cognitive impairment subtypes: Findings from the Italian project on the epidemiology of Alzheimer's disease (IPREA)

Solfrizzi, Vincenzo; Scafato, Emanuele; Custodero, Carlo; Piazzolla, Giuseppina; Capogna, Lavinia; Procaccio, Annagrazia; Gandin, Claudia; Galluzzo, Lucia; Ghirini, Silvia; Matone, Alice; Dibello, Vittorio; Sardone, Rodolfo; Daniele, Antonio; Lozupone, Madia

doi:10.1002/alz.12944

Cited by 8 publications

(2 citation statements)

References 61 publications

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“…Aging was another topic identified in this study that received a long attention span and a high co-citation rate. Aging processes were often accompanied by an increase in frailty [ 49 ], falls [ 50 ], and sarcopenia [ 51 ], which were risk factors for head injury or stroke and can reduce the ability of older people to participate in physical activity and may lead to a decline in cognitive function [ 52 – 54 ]. Nevertheless, exercise had been shown to positively impact the aging process by combating typical signs such as frailty, balance issues, and sarcopenia [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Zhu,

Hu,

Luo

et al. 2024

Aging Clin Exp Res

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Exercise elicits a wide range of physiological responses in mammalian tissues that enhance a broad range of functions, particularly in improving cognitive performance. However, the field lacks a comprehensive bibliometric analysis that clarifies its knowledge structure and research hotspots. This study aims to address this gap and map the research landscape regarding the role of exercise in cognitive function enhancement. Firstly, the frequencies and co-occurrence of keywords were analysed to identify six main clusters: aging, cognitive impairment, rehabilitation, obesity, fatigue, and hippocampus. Secondly, reference timeline co-citation analysis revealed that hippocampus and aging were the major bursts with high intensity and long attention span while children had recently emerged as a topical subject. Finally, the evolution of themes from 2012 to 2022 was analysed, and found that older adults had been the leading research theme for exercise affecting cognition. Childhood obesity was an emerging theme that attracted increasing research attention in recent years while the hippocampus research theme expanded rapidly during the decade but remained a niche topic with less relevance to others. This research identified and summarised research priorities and evolutionary trends in exercise to improve cognition by constructing knowledge networks through visual analysis. It provides researchers with a comprehensive insight into the current state of the field to facilitate further research.

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Section: Discussionmentioning

confidence: 99%

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Zhu,

Hu,

Luo

et al. 2024

Aging Clin Exp Res

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“…En una amplia cohorte italiana de 10 años de seguimiento, la fragilidad física se asoció de forma significativa a un mayor riesgo de deterioro cognitivo leve ( odds ratio: 4,36; IC 95%: 2,6-7,29), que fue mayor con el no mnésico ( odds ratio: 3,28; IC 95%: 1,35-7,97), y especialmente el no mnésico multidominio ( odds ratio: 6,92; IC 95%: 3,37-14,21) [ 18 ]. En este sentido, las personas mayores con niveles más altos de fragilidad tienen más probabilidad de presentar mayor neuropatología de la enfermedad de Alzheimer, así como de manifestarse con demencia [ 19 ].…”

Section: Fragilidad Y Enfermedades Neurológicas: Implicación En La Pr...unclassified

Concepto y manejo práctico de la fragilidad en neurología

Cristofori¹,

Aguado-Ortego²,

Gómez-Pavón³

2023

RevNeurol

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La fragilidad se entiende como un situación clínica de disminución de la reserva homeostática que, ante un desencadenante (enfermedad aguda, caída, toma de un fármaco…), aumenta el riesgo de un evento adverso, como ingreso hospitalario, en residencia, deterioro funcional y/o cognitivo, muerte, etc. La fragilidad puede entenderse como fragilidad física, fenotipo de Fried, verdadero síndrome geriátrico, que puede ser reversible evitando su progresión a estadios más avanzados de irreversibilidad y de dependencia, y fragilidad por acúmulo de déficits de Rockwood, como continuum de salud o tipología de clasificación del anciano a lo largo del espectro de la fragilidad (sano, robusto, vulnerable, fragilidad leve-moderada-grave y extrema o final de vida). El diagnóstico de fragilidad física forma parte de la valoración geriátrica integral y se recomienda para su diagnóstico utilizar un test de ejecución, como velocidad de la marcha (<0,8 m/s), Timed Up and Go (>12 segundos) o Short Physical Performance Battery (<10). La fragilidad física es reversible basándose en un tratamiento multidisciplinar sobre tres pilares fundamentales: ejercicio físico multicompetente y contra resistencia, aporte adecuado de proteínas y micronutrientes (leucina, vitamina D, etc.), y adecuada prescripción farmacológica, de tratamiento de comorbilidad y de síndromes geriátricos. La fragilidad es un factor de riesgo de progresión de la enfermedad neurológica y de mayor riesgo de evento adverso tanto en enfermedades neurodegenerativas, como el deterioro cognitivo leve, la demencia o la enfermedad de Parkinson, como en la enfermedad cerebrovascular. La fragilidad a través de la Clinical Frailty Scale o el VIG-Frail muestra tipologías de pacientes en relación con un mayor o menor estado de fragilidad, y es una herramienta básica pronóstica de gran utilidad en la toma de decisiones de manejo diagnóstico y terapéutico. Se abre una nueva oportunidad de mejora en el manejo de la enfermedad neurológica ante el diagnóstico y el tratamiento de la fragilidad.

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Associations of a biopsychosocial frailty phenotype with all-cause dementia, Alzheimer’s disease, vascular dementia, and other dementias: the Italian PRoject on the Epidemiology of Alzheimer’s disease (IPREA)

et al. 2023

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Biopsychosocial frailty and mild cognitive impairment subtypes: Findings from the Italian project on the epidemiology of Alzheimer's disease (IPREA)

Cited by 8 publications

References 61 publications

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Knowledge mapping of trends and hotspots in the field of exercise and cognition research over the past decade

Concepto y manejo práctico de la fragilidad en neurología

Associations of a biopsychosocial frailty phenotype with all-cause dementia, Alzheimer’s disease, vascular dementia, and other dementias: the Italian PRoject on the Epidemiology of Alzheimer’s disease (IPREA)

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