Biopsychosocial factors associated with pain in veterans with the hepatitis C virus

Morasco, Benjamin J.; Lovejoy, Travis I.; Turk, Dennis C.; Crain, Aysha; Hauser, Péter; Dobscha, Steven K.

doi:10.1007/s10865-013-9549-y

Cited by 19 publications

(24 citation statements)

References 55 publications

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“…Prior research demonstrates high comorbidity of major depressive disorder among patients with chronic pain and vice versa [18]. In this sample of veterans with HCV, 43% had clinically-significant symptoms of depression and 58% had chronic pain, rates which are consistent with prior research [11,13,17,21,24]. Twenty-six percent of patients had both depressive symptoms and chronic pain, a rate of comorbidity that is substantially higher than observed in the general population [44].…”

Section: Discussionsupporting

confidence: 86%

“…Moreover, patients with HCV and chronic pain utilize more medical services than patients with HCV alone, including primary care visits, overall hospital services, and pain specialty services [15]. Research indicates that psychological factors are significantly associated with chronic pain in patients with HCV; notably, pain catastrophizing, perceived self-efficacy for managing pain, and depressive symptoms have been shown to be predictive of pain severity and declines in physical function [16,17]. …”

Section: Introductionmentioning

confidence: 99%

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Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C

Adams

Lovejoy

Turk

et al. 2015

General Hospital Psychiatry

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Objective Depression and chronic pain are common in persons chronically infected with the hepatitis C virus (HCV), although little is known about the rate of co-occurrence or mechanisms by which they are associated. We evaluated whether pain-related anxiety mediates the relationship between depressive symptoms and pain-related physical functioning in patients with HCV. Methods Patients with HCV (n=175) completed self-report measures assessing demographic characteristics, pain-related function, and mental health. Path analyses examined direct effects of cognitive-affective and somatic symptoms of depression on pain interference and indirect effects of these relationships via four subscales of the Pain Anxiety Symptoms Scale-20. Results Cognitive-affective and somatic symptoms of depression were positively and significantly related to pain interference. Pain-related anxiety mediated the relationship between both cognitive-affective and somatic symptoms of depression, and this mediation was predominantly accounted for by the escape-avoidance component of pain-related anxiety. Conclusions Findings indicate a potential mediating role of pain-related anxiety, particularly escape-avoidance anxiety, on the relationship between depression and pain interference in patients with HCV. These findings suggest that escape-avoidance anxiety may be a particularly germane target for treatment in patients with HCV and chronic pain, particularly when depression, with characteristic features of withdrawal and inhibition, is a comorbid condition.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C

Adams

Lovejoy

Turk

et al. 2015

General Hospital Psychiatry

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“…However, although it is tempting to generalize the results of existing studies to real‐world situations, we note that effects on evoked, acute pain may not translate to tonic, clinical pain. Future studies may explore how love‐related analgesia reduces the severity of chronic pain and integrate related lines of research such as pain and social support [26].…”

Section: Discussionmentioning

confidence: 99%

Preoccupation in an Early-Romantic Relationship Predicts Experimental Pain Relief

et al. 2014

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Objective Individuals involved in the early stages of a passionate romantic relationship can be consumed by the experience and report emotional dependence and constant focus on their romantic partner. A few studies have shown that viewing pictures of a romantic partner can significantly reduce experimental pain. The strength of the effect, however, varies substantially between individuals. To study why some individuals experience significant pain reduction when looking at a picture of their partner, we examined partner preoccupation. We hypothesized that a greater degree of preoccupation in the early stages of a romantic relationship would be associated with greater analgesia during a pain induction task. Methods Participants were shown pictures of their romantic partner or an equally attractive and familiar acquaintance while exposed to low, moderate or high levels of thermal pain. Participants were also asked to rate how much time they spent thinking about their romantic partner during an average day. Degree of preoccupation was defined as the percentage of time participants spent thinking about their partner on an average day. Results In two separate experiments, viewing pictures of a romantic partner produced an analgesic effect. The degree of pain relief was positively correlated with partner preoccupation. The results suggest that preoccupation with a romantic partner during early stage romantic love is a predictor of pain relief when viewing pictures of the beloved.

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“…Participants in these analyses were originally recruited for a larger study examining the relationship between chronic pain, hepatitis C virus (HCV) infection, and substance abuse [32]. Patients who had been tested for HCV were eligible to participate and a total of 284 were enrolled into the larger study.…”

Section: Methodsmentioning

confidence: 99%

Associations Between Prescription Opioid Use and Sleep Impairment among Veterans with Chronic Pain

Morasco¹,

O’Hearn

Turk

et al. 2014

Pain Med

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Biopsychosocial factors associated with pain in veterans with the hepatitis C virus

Cited by 19 publications

References 55 publications

Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C

Pain-related anxiety mediates the relationship between depressive symptoms and pain interference in veterans with hepatitis C

Preoccupation in an Early-Romantic Relationship Predicts Experimental Pain Relief

Associations Between Prescription Opioid Use and Sleep Impairment among Veterans with Chronic Pain

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