Abstract:Systemic sclerosis (SSc) is a rare, chronic connective tissue disease with characteristic fibrosis of the skin, musculoskeletal system, and internal organs. It is a heterogeneous and polymorphic disorder, in which fatigue, sleep disturbances, stiffness, and joint pain are among the most significant clinical symptoms. However, the presence of stiffening and thickening of the skin usually has a negative impact on the appearance of these patients, and the degree of self-dissatisfaction can fundamentally interfere… Show more
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