Biopsia del ganglio centinela en pacientes con cáncer de mama operable tratadas con quimioterapia neoadyuvante

Rebollo-Aguirre, Á.C.; Gallego-Peinado, M.; Menjón-Beltrán, Salomón; García-García, Juan; Pastor-Pons, E.; Chamorro‐Santos, Clara; Ramos-Font, C.; Salamanca-Ballesteros, A.; Elvira, J.M. Llamas; Olea, Nicolás

doi:10.1016/j.remn.2011.04.007

Cited by 11 publications

(11 citation statements)

References 22 publications

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“…Fourteen studies were single-center studies [ 25 , 27 – 32 , 34 – 40 ], and the other two were multi-center studies [ 26 , 33 ]. Four studies were from Japan [ 28 , 30 , 38 , 40 ], 3 from the United States [ 25 , 26 , 34 ], 2 from France [ 31 , 33 ], 2 from Spain [ 37 , 39 ], and 1 each from Austria [ 35 ], Brazil [ 27 ], the Czech Republic [ 36 ], Israel [ 32 ], and Chinese Taipei [ 29 ]. All of the studies included a group of patients who were clinically node-negative at the time of diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies performed SN mapping using radiocolloid alone [ 27 , 31 , 32 , 37 ], three studies used blue dye alone [ 28 , 29 , 40 ], and 6 studies used both radiocolloid and blue dye [ 25 , 26 , 33 – 35 , 38 ]. Regarding histological technique, 6 studies used hematoxylin and eosin (H&E) staining alone [ 27 , 28 , 30 , 32 , 37 , 40 ], 3 studies performed additional IHC staining for negative nodes based on H&E staining results [ 25 , 31 , 33 ], and 3 studies used IHC staining in all cases [ 29 , 34 , 38 ]. Detailed descriptions of the included studies are summarized in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

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The Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Initially Clinically Node-Negative Breast Cancer after Neoadjuvant Chemotherapy: A Systematic Review and Meta-Analysis

et al. 2016

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BackgroundWith the increased use of neoadjuvant chemotherapy (NAC) in breast cancer, the timing of sentinel lymph node biopsy (SLNB) has become increasingly important. In this study, we aimed to evaluate the feasibility and accuracy of SLNB for initially clinically node-negative breast cancer after NAC by conducting a systematic review and meta-analysis.MethodsWe searched PubMed, Embase, and the Cochrane Library from January 1, 1993 to November 30, 2015 for studies on initially clinically node-negative breast cancer patients who underwent SLNB after NAC followed by axillary lymph node dissection (ALND).ResultsA total of 1,456 patients from 16 studies were included in this review. The pooled identification rate (IR) for SLNB was 96% [95% confidence interval (CI): 95%-97%], and the false negative rate (FNR) was 6% (95% CI: 3%-8%). The pooled sensitivity, negative predictive value (NPV) and accuracy rate (AR) were 94% (95% CI: 92%-97%, I2 = 27.5%), 98% (95% CI: 98%-99%, I2 = 42.7%) and 99% (95% CI: 99%-100%, I2 = 32.6%), respectively. In the subgroup analysis, no significant differences were found in either the IR of an SLNB when different mapping methods were used (P = 0.180) or in the FNR between studies with and without immunohistochemistry (IHC) staining (P = 0.241).ConclusionBased on current evidence, SLNB is technically feasible and accurate enough for axillary staging in initially clinically node-negative breast cancer patients after NAC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Initially Clinically Node-Negative Breast Cancer after Neoadjuvant Chemotherapy: A Systematic Review and Meta-Analysis

et al. 2016

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“…Three studies only included patients who achieved clinically complete responses of axillary nodes after NAC[17], [20], [25]. With respect to the mapping technique, blue dye alone was used in one study[25], radioactive isotopes alone were used in three studies[15], [21], [22], a combination of blue dye and radionuclides was used in five studies[16], [19], [20], [24], [26], and mixed techniques were used in the other six studies[12]–[14], [17], [18], [23]. Seven studies performed additional IHC staining with anti-cytokeratin antibodies on negative nodes according to routine hematoxylin and eosin (H&E) staining[15], [16], [18], [20], [22], [25], [26].…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies performed additional IHC staining with anti-cytokeratin antibodies on negative nodes according to routine hematoxylin and eosin (H&E) staining[15], [16], [18], [20], [22], [25], [26]. Sentinel lymph nodes with micro-metastases (<2 mm) were considered positive in two studies[22], [25] (Table 2). …”

Section: Resultsmentioning

confidence: 99%

Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Clinically Node-Positive Breast Cancer after Neoadjuvant Chemotherapy: A Meta-Analysis

Chen

Jiao

et al. 2014

PLoS ONE

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Sentinel lymph node biopsy (SLNB) has replaced conventional axillary lymph node dissection (ALND) in axillary node-negative breast cancer patients. However, the use of SLNB remains controversial in patients after neoadjuvant chemotherapy (NAC). The aim of this review is to evaluate the feasibility and accuracy of SLNB after NAC in clinically node-positive patients. Systematic searches were performed in the PubMed, Embase, and Cochrane Library databases from 1993 to December 2013 for studies on node-positive breast cancer patients who underwent SLNB after NAC followed by ALND. Of 436 identified studies, 15 were included in this review, with a total of 2,471 patients. The pooled identification rate (IR) of SLNB was 89% [95% confidence interval (CI) 85–93%], and the false negative rate (FNR) of SLNB was 14% (95% CI 10–17%). The heterogeneity of FNR was analyzed by meta-regression, and the results revealed that immunohistochemistry (IHC) staining may represent an independent factor (P = 0.04). FNR was lower in the IHC combined with hematoxylin and eosin (H&E) staining subgroup than in the H&E staining alone subgroup, with values of 8.7% versus 16.0%, respectively (P = 0.001). Thus, SLNB was feasible after NAC in node-positive breast cancer patients. In addition, the IR of SLNB was respectable, although the FNR of SLNB was poor and requires further improvement. These findings indicate that IHC may improve the accuracy of SLNB.

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“…Sin embargo, persiste una amplia controversia sobre la realización de BSGC en pacientes con CM sometidas a QNA, pues aparecen altas tasas de falsos negativos 4,5 .…”

Section: Introductionunclassified

Detección selectiva del ganglio centinela tras administración intratumoral del radiotrazador, en pacientes con cáncer de mama tratadas con quimioterapia neoadyuvante en relación con el grado de respuesta tumoral

Díaz-Expósito

Martí‐Bonmatí

Burgués

et al. 2016

Revista Española de Medicina Nuclear e Imagen Molecular

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Biopsia del ganglio centinela en pacientes con cáncer de mama operable tratadas con quimioterapia neoadyuvante

Cited by 11 publications

References 22 publications

The Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Initially Clinically Node-Negative Breast Cancer after Neoadjuvant Chemotherapy: A Systematic Review and Meta-Analysis

The Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Initially Clinically Node-Negative Breast Cancer after Neoadjuvant Chemotherapy: A Systematic Review and Meta-Analysis

Feasibility and Accuracy of Sentinel Lymph Node Biopsy in Clinically Node-Positive Breast Cancer after Neoadjuvant Chemotherapy: A Meta-Analysis

Detección selectiva del ganglio centinela tras administración intratumoral del radiotrazador, en pacientes con cáncer de mama tratadas con quimioterapia neoadyuvante en relación con el grado de respuesta tumoral

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