Bioprospection of Orchids and Appraisal of Their Therapeutic Indications

Ghai, Devina; Verma, Jagdeep; Kaur, Arvinder; Thakur, Kranti; Pawar, Sandip V.; Sembi, Jaspreet K.

doi:10.1002/9781119718017.ch20

Cited by 4 publications

(1 citation statement)

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“…These secondary metabolites can be grouped into various classes like alkaloids, terpenoids, polyphenols, phenanthrene, bibenzyl derivatives, etc. Therapeutic effects of different alkaloids especially terpenoid alkaloids have been widely reported in orchids (Sut et al, 2017;Gantait et al, 2021;Ghai et al, 2021). These terpenes alkaloids are formed through the mevalonate (MVA) pathway and methyl-D-erythritol 4-phosphate (MEP) pathway (Figure 2).…”

Section: Functional Annotation Of Secondary Metabolism Specific Genesmentioning

confidence: 99%

A Walk Through the Maze of Secondary Metabolism in Orchids: A Transcriptomic Approach

et al. 2022

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Orchids have a huge reservoir of secondary metabolites making these plants of immense therapeutic importance. Their potential as curatives has been realized since times immemorial and are extensively studied for their medicinal properties. Secondary metabolism is under stringent genetic control in plants and several molecular factors are involved in regulating the production of the metabolites. However, due to the complex molecular networks, a complete understanding of the specific molecular cues is lacking. High-throughput omics technologies have the potential to fill up this lacuna. The present study deals with comparative analysis of high-throughput transcript data involving gene identification, functional annotation, and differential expression in more than 30 orchid transcriptome data sets, with a focus to elucidate the role of various factors in alkaloid and flavonoid biosynthesis. Comprehensive analysis of the mevalonate (MVA) pathway, methyl-d-erythritol 4-phosphate (MEP) pathway, and phenylpropanoid pathway provide specific insights to the potential gene targets for drug discovery. It is envisaged that a positive stimulation of these pathways through regulation of pivotal genes and alteration of specific gene expression, could facilitate the production of secondary metabolites and enable efficient tapping of the therapeutic potential of orchids. This further would lay the foundation for developing strategies for genetic and epigenetic improvement of these plants for development of therapeutic products.

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Section: Functional Annotation Of Secondary Metabolism Specific Genesmentioning

confidence: 99%