Bioprospection of novel synthetic monocurcuminoids: Antioxidant, antimicrobial, and in vitro cytotoxic activities

Cerveira, Milena Mattes; Vianna, Helena Silveira; Ferrer, Edila Maria Kickhofel; Rosa, Bruno Nunes da; Pereira, Cláudio M. P.; Baldissera, Matheus D.; Lopes, Leonardo Quintana Soares; Rech, Virgínia Cielo; Giongo, Janice Luehring; Vaucher, Rodrigo de Almeida

doi:10.1016/j.biopha.2020.111052

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…Anticoagulant activity was determined based on thromboplastin partial actived time (aTTP) and prothrombin time (TP), which indicate the intrinsic and extrinsic coagulation pathways, respectively, in citrated plasma [ 24 ]. The patient samples were then centrifuged at 800× g for 10 min aTTP and TP were determined using monochannel coagulometer (Clotimer, Brazil) with commercial kits (Biotécnica, Varginha, Minas Gerais, Brazil), following the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Trassante¹,

Barboza²,

Rocha³

et al. 2021

Microbial Pathogenesis

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In early December 2019, an outbreak of coronavirus disease 2019 caused by a new strain of coronavirus (SARS-CoV-2), occurred in the city of Wuhan, Hubei Province, China. On January 30, 2020, the World Health Organization (WHO) declared the outbreak a public health emergency of international concern. Since then, frontline healthcare professionals have been experiencing extremely stressful situations and damage to their physical and mental health. These adverse conditions cause stress and biochemical, hematological, and inflammatory changes, as well as oxidative damage, and could be potentially detrimental to the health of the individual. The study population consisted of frontline health professionals working in BHU in a city in southern Brazil. Among the 45 participants, two were infected with the SARS-CoV-2 virus and were diagnosed using immunochromatographic tests such as salivary RT-LAMP and qRT-PCR. We also evaluated biochemical, hematological, inflammatory, and oxidative stress markers in the participants. The infected professionals (CoV-2-Prof) showed a significant increase in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), cholesterol, lactic dehydrogenase, lymphocytes, and monocytes. In this group, the levels of uric acid, triglycerides, leukocytes, neutrophils, hemoglobin, hematocrit, and platelets decreased. In the group of uninfected professionals (NoCoV-2-Prof), significant increase in HDL levels and the percentages of eosinophils and monocytes, was observed. Further, in this group, uric acid, LDH, triglyceride, and cholesterol levels, and the hematocrit count and mean corpuscular volume were significantly reduced. Both groups showed significant inflammatory activity with changes in the levels of C-reactive protein and mucoprotein. The NoCoV-2-Prof group showed significantly elevated plasma cortisol levels. To our kowledge, this study is the first to report the use of the RT-LAMP method with the saliva samples of health professionals, to evalute of SARS-CoV-2.

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Section: Methodsmentioning

confidence: 99%

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Trassante¹,

Barboza²,

Rocha³

et al. 2021

Microbial Pathogenesis

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“…Two MC and turmeric powder presented synergism against A. hydrophila, P. aeruginosa, and C. albicans. When aPDT was performed with UV light, two MC-mediated aPDT decreased the growth of E. faecalis, E. coli, and S. aureus, while aPDT with another MC and Cur increased the growth of A. hydrophila, E. faecalis, S. aureus, C. albicans, and P. aeruginosa (160). Cur was more effective than other natural biomolecules (quercetin and resveratrol) in inhibiting the growth of E. faecalis in spermatozoa from rabbits, but less effective than antibiotics (161).…”

Section: Anti-microbial Impacts Of Curcuminmentioning

confidence: 99%

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

et al. 2023

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The yellow polyphenolic pigment known as curcumin, originating from the rhizome of the turmeric plant Curcuma longa L., has been utilized for ages in ancient medicine, as well as in cooking and food coloring. Recently, the biological activities of turmeric and curcumin have been thoroughly investigated. The studies mainly focused on their antioxidant, antitumor, anti-inflammatory, neuroprotective, hepatoprotective, and cardioprotective impacts. This review seeks to provide an in-depth, detailed discussion of curcumin usage within the food processing industries and its effect on health support and disease prevention. Curcumin’s bioavailability, bio-efficacy, and bio-safety characteristics, as well as its side effects and quality standards, are also discussed. Finally, curcumin’s multifaceted uses, food appeal enhancement, agro-industrial techniques counteracting its instability and low bioavailability, nanotechnology and focused drug delivery systems to increase its bioavailability, and prospective clinical use tactics are all discussed.

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“…CUR analogs (monocurcuminoids, MC) were synthesized and showed higher, lower, or similar antimicrobial activity than CUR against Aeromonas hydrophila, E. coli, E. faecalis, K. pneumoniae, P. aeruginosa, S. aureus, and the yeast Candida albicans [49]. Two MC and turmeric powder presented synergism against A. hydrophila, P. aeruginosa, and C. albicans.…”

Section: Antibacterial Activitymentioning

confidence: 99%

“…Two MC and turmeric powder presented synergism against A. hydrophila, P. aeruginosa, and C. albicans. When aPDT was performed with UV light, two MC-mediated aPDT decreased the growth of E. faecalis, E. coli, and S. aureus, while aPDT with another MC and CUR increased the growth of A. hydrophila, E. faecalis, S. aureus, C. albicans, and P. aeruginosa [49]. CUR was more effective than other natural biomolecules (quercetin and resveratrol) in inhibiting the growth of E. faecalis in spermatozoa from rabbits, but less effective than antibiotics [50].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

Trigo-Gutierrez

Vega-Chacón

Soares

et al. 2021

IJMS

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Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, and has low bioavailability, which hinders its clinical use. To circumvent these drawbacks, drug delivery systems (DDSs) have been used. In this review, we summarize the DDSs used to carry CUR and their antimicrobial effect against viruses, bacteria, and fungi, including drug-resistant strains and emergent pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used alone or as a PS in aPDT. They also show low cytotoxicity, in vivo biocompatibility, and improved wound healing. Although there are several in vitro and some in vivo investigations describing the nanotechnological aspects and the potential antimicrobial application of CUR-loaded DDSs, clinical trials are not reported and further studies should translate this evidence to the clinical scenarios of infections.

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Bioprospection of novel synthetic monocurcuminoids: Antioxidant, antimicrobial, and in vitro cytotoxic activities

Cited by 8 publications

References 31 publications

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals

Impacts of turmeric and its principal bioactive curcumin on human health: Pharmaceutical, medicinal, and food applications: A comprehensive review

Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review

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