Bioprospecting of microalgae metabolites against cytokine storm syndrome during COVID-19

Lah, Wan Afifudeen Che; Teh, Kit Yinn; San, Thye

doi:10.1007/s11033-021-06903-y

Cited by 5 publications

(2 citation statements)

References 104 publications

(163 reference statements)

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“…Likewise, several human cytokines (e.g., erythropoietin, interferon alpha 2a, and interleukin 2), human hormones (i.e., growth hormone and VEGF-165), and other biologics (antigens and multi-epitope proteins) have been produced with appropriate functionality in green microalgae such as Chlamydomonas reinhardtii, Chlorella, and Dunaliella species (Table 1) [73][74][75]. Some eukaryotic microalgae (e.g., C. reinhardtii, Chlorella vulgaris, Dunaliella salina, and P. tricornutum), and also the cyanobacterium Arthrospira platensis (previously categorized as blue-green microalga) produce vital components, including essential amino acids and different groups of vitamins that are necessary to boost the immune system against various diseases including infectious diseases (e.g., COVID-19) due to their anti-inflammatory and tissue-repairing properties [76,77]. Severe inflammatory responses can be observed in COVID-19 patients due to outof-control cytokine storm reactions.…”

Section: Potential Of Microalgae For the Production Of Recombinant S-...mentioning

confidence: 99%

Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants

et al. 2022

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Severe acute respiratory syndrome–Coronavirus 2 (SARS-CoV-2) can infect various human organs, including the respiratory, circulatory, nervous, and gastrointestinal ones. The virus is internalized into human cells by binding to the human angiotensin-converting enzyme 2 (ACE2) receptor through its spike protein (S-glycoprotein). As S-glycoprotein is required for the attachment and entry into the human target cells, it is the primary mediator of SARS-CoV-2 infectivity. Currently, this glycoprotein has received considerable attention as a key component for the development of antiviral vaccines or biologics against SARS-CoV-2. Moreover, since the ACE2 receptor constitutes the main entry route for the SARS-CoV-2 virus, its soluble form could be considered as a promising approach for the treatment of coronavirus disease 2019 infection (COVID-19). Both S-glycoprotein and ACE2 are highly glycosylated molecules containing 22 and 7 consensus N-glycosylation sites, respectively. The N-glycan structures attached to these specific sites are required for the folding, conformation, recycling, and biological activity of both glycoproteins. Thus far, recombinant S-glycoprotein and ACE2 have been produced primarily in mammalian cells, which is an expensive process. Therefore, benefiting from a cheaper cell-based biofactory would be a good value added to the development of cost-effective recombinant vaccines and biopharmaceuticals directed against COVID-19. To this end, efficient protein synthesis machinery and the ability to properly impose post-translational modifications make microalgae an eco-friendly platform for the production of pharmaceutical glycoproteins. Notably, several microalgae (e.g., Chlamydomonas reinhardtii, Dunaliella bardawil, and Chlorella species) are already approved by the U.S. Food and Drug Administration (FDA) as safe human food. Because microalgal cells contain a rigid cell wall that could act as a natural encapsulation to protect the recombinant proteins from the aggressive environment of the stomach, this feature could be used for the rapid production and edible targeted delivery of S-glycoprotein and soluble ACE2 for the treatment/inhibition of SARS-CoV-2. Herein, we have reviewed the pathogenesis mechanism of SARS-CoV-2 and then highlighted the potential of microalgae for the treatment/inhibition of COVID-19 infection.

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Section: Potential Of Microalgae For the Production Of Recombinant S-...mentioning

confidence: 99%

Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants

et al. 2022

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“…In a more recent context, thanks to the antiinfl ammatory eff ect of some microalgae species, nonaqueous extracts could be used as a treatment to heal the symptoms of COVID-19 and could induce better defense mechanisms and better responses in the lymphocytes [84].…”

Section: Traditional and Current Usementioning

confidence: 99%

Microalgae and Diatom - Potential Pharmaceutical and Cosmetic Resources – Review

Dussably¹,

Mshvildadze²,

Pichette³

et al. 2022

J Biomed Res Environ Sci

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Microalgae are aquatic resources containing several value-added products which have been and will be widely used in various industries. They have the high potential to be explored in cosmetics and cosmeceuticals, as active ingredients in the form of isolated molecules or extracts. The aim of this review is to exhibit the potential of microalgae and especially diatoms for their cosmetic application regarding their phytochemistry and pharmacological activity. Comprehensive study of previously published literature demonstrated the presence of several antioxidant, antimicrobial or anti-inflammatory molecules in microalgae and their efficiency on human cells, particularly in anti-aging and anti-UV products. This review summarizes and discusses the information on extraction process, the chemical composition and biological activity of natural microalgae biomass. Finally, the review attempts to reveal more global view on how to valorize natural microalgal biomass, including diatoms, in cosmetics to prevent a destruction of wild resources.

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In silico and in vitro evaluation of extract derived from Dunaliella salina, a halotolerant microalga for its antifungal and antibacterial activity

Singh

Laxmi

Singh

et al. 2022

Journal of Biomolecular Structure and Dynamics

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Bioprospecting of microalgae metabolites against cytokine storm syndrome during COVID-19

Cited by 5 publications

References 104 publications

Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants

Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants

Microalgae and Diatom - Potential Pharmaceutical and Cosmetic Resources – Review

In silico and in vitro evaluation of extract derived from Dunaliella salina, a halotolerant microalga for its antifungal and antibacterial activity

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