Bioprospecting of indigenous myxobacteria from Iran and potential of Cystobacter as a source of anti-MDR compounds

Saadatpour, Fatemeh; Mohammadipanah, Fatemeh

doi:10.1007/s12223-019-00768-2

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…However, the Cystobacter fruiting bodies differ in morphology to those of the Myxococcus genus, and are shiny, spherical and held within a slime matrix, whereas the latter are characterised by haystack-shaped cell aggregates ( Treuner-Lange et al, 2017 ). Cystobacter species have a relatively large genome size, thus enabling them to produce a vast range of secondary metabolites, including bacteriocins, polyketides, lantipeptides and microcins ( Saadatpour and Mohammadipanah, 2020 ). Although their potential lipopeptide production has been relatively underexplored ( Burgard et al, 2017 ), one lipopeptide family, namely the cystomanamide lipopeptides, has been characterised ( Etzbach et al, 2014 ).…”

Section: Antimicrobial Lipopeptides: Production By Underexplored Pred...mentioning

confidence: 99%

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

et al. 2022

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Natural products derived from microorganisms play a prominent role in drug discovery as potential anti-infective agents. Over the past few decades, lipopeptides produced by particularly Bacillus, Pseudomonas, Streptomyces, Paenibacillus, and cyanobacteria species, have been extensively studied for their antimicrobial potential. Subsequently, daptomycin and polymyxin B were approved by the Food and Drug Administration as lipopeptide antibiotics. Recent studies have however, indicated that Serratia, Brevibacillus, and Burkholderia, as well as predatory bacteria such as Myxococcus, Lysobacter, and Cystobacter, hold promise as relatively underexplored sources of novel classes of lipopeptides. This review will thus highlight the structures and the newly discovered scaffolds of lipopeptide families produced by these bacterial genera, with potential antimicrobial activities. Additionally, insight into the mode of action and biosynthesis of these lipopeptides will be provided and the application of a genome mining approach, to ascertain the biosynthetic gene cluster potential of these bacterial genera (genomes available on the National Center for Biotechnology Information) for their future pharmaceutical exploitation, will be discussed.

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Section: Antimicrobial Lipopeptides: Production By Underexplored Pred...mentioning

confidence: 99%

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

et al. 2022

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“…Currently, NPs have multiple applications in human health, industry and environmental protection and they are anticipated to be involved in many more areas in the future. The large chemical structural diversity and consequently divergent biological activities of NPs has made them a prominent source for various pharmaceutical products, including antivirals [ 6 ], anti-Alzheimer compounds [ 7 ], immunosuppressives [ 8 ], antioxidants [ 9 ], antimicrobials [ 10 ], anti-inflammatory compounds [ 11 ], anti-adipogenic agents, digestive agents, and stimulants [ 12 ]. In the last decade, a decrease in NP discovery has caused a dramatic decline in discovery of new drugs [ 2 ].…”

Section: Natural Productsmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

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Natural products (NPs) are a valuable source in the food, pharmaceutical, agricultural, environmental, and many other industrial sectors. Their beneficial properties along with their potential toxicities make the detection, determination or quantification of NPs essential for their application. The advanced instrumental methods require time-consuming sample preparation and analysis. In contrast, biosensors allow rapid detection of NPs, especially in complex media, and are the preferred choice of detection when speed and high throughput are intended. Here, we review diverse biosensors reported for the detection of NPs. The emerging approaches for improving the efficiency of biosensors, such as microfluidics, nanotechnology, and magnetic beads, are also discussed. The simultaneous use of two detection techniques is suggested as a robust strategy for precise detection of a specific NP with structural complexity in complicated matrices. The parallel detection of a variety of NPs structures or biological activities in a mixture of extract in a single detection phase is among the anticipated future advancements in this field which can be achieved using multisystem biosensors applying multiple flow cells, sensing elements, and detection mechanisms on miniaturized folded chips.

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“…Hundreds of compounds have been found through decades of research [5], among which is the novel compound known as epothilone, whose derivative, has been commercialized as a medication for human breast cancer treatment [6]. More than 100 metabolites and 600 derivatives related to myxobacteria have been found [5,7]. Myxobacteria were considered outstanding secondary metabolite producers for drug development because they are able to produce novel compounds that have useful bioactivities, after Actinobacteria, they are the second most proli c makers of these compounds [8].…”

Section: Introductionmentioning

confidence: 99%

Myxobacteria From Vietnam: Isolation, Phylogenetic Analysis and Bioprospection

Nguyen

Duong

Nguyen

et al. 2023

Preprint

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Myxobacteria have been considered microbial factories for producing secondary metabolites that have a variety of potential biological actions for discovering and isolating new biological molecules. Forty-three myxobacterial strains were isolated and identified from 20 soil samples collected in Vietnam. The information on morphological characteristics and phylogenetic analysis inferred from 16S ribosomal gene showed that the newly isolated myxobacterial strains were classified into seven genera of Angiococcus, Archangium, Corallococcus, Cystobacter, Melittangium, and Myxococcus. Antioxidant activity was measured with the DPPH and ABTS assays; the minimum inhibitory concentration values were determined by the microdilution method. The extract from CT21 strain had the highest total antioxidant activity (IC50 = 52.34 ± 1.47 and 30.28 ± 0.74 μg/mL for the DPPH and ABTS, respectively). Interestingly, all strains isolated myxobacterial strains show inhibitory activity against at least one of the tested microorganisms. The most potent antimicrobial strain was GL41, which inhibited all tested microorganisms, and the MIC values were 1 μg/mL against MRSA, MSSA, S. faecalis, C. albicans, and A. niger. Almost all active strains were members of the Myxococcus genus, among of which, GL41 strain was identified as Myxococcus stipitatus. Myxobacteria strains isolated from soil are a potent source of bioactive metabolite production.

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Bioprospecting of indigenous myxobacteria from Iran and potential of Cystobacter as a source of anti-MDR compounds

Cited by 9 publications

References 37 publications

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

Underexplored bacteria as reservoirs of novel antimicrobial lipopeptides

Emerging biosensors in detection of natural products

Myxobacteria From Vietnam: Isolation, Phylogenetic Analysis and Bioprospection

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