Bioprospecting of fucoxanthin from diatoms — Challenges and perspectives

Seth, Kunal; Kumar, Ashwani; Rastogi, Rajesh P.; Meena, Mukesh; Vinayak, Vandana; Harish,

doi:10.1016/j.algal.2021.102475

Cited by 47 publications

(29 citation statements)

References 76 publications

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“…Fucoxanthin, a bioactive microalgal compound, can be found in several species of diatoms (golden-brown microalgae) and has remarkable antioxidant, anti-obesity, anti-diabetic, anti-cancer, anti-inflammatory, anti-hypertensive, and anti-osteoporotic properties. Fucoxanthin is an important carotenoid for human health that is marketed at USD 30,000 per gram and is considered a valued nutraceutical product or functional food to prevent or help treat different diseases [ 72 , 73 , 74 ]. Recent research on the use of diatoms rich in carotenoids has been extended to space missions where resources are limited and the need to implement CO 2 recycling systems provides an opportunity to produce O 2 and food based on microalgal biomass as an alternative to health supplementation for humans in these conditions [ 69 , 75 , 76 ].…”

Section: Antioxidantsmentioning

confidence: 99%

Microalgae Bioactive Compounds to Topical Applications Products—A Review

et al. 2022

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Microalgae are complex photosynthetic organisms found in marine and freshwater environments that produce valuable metabolites. Microalgae-derived metabolites have gained remarkable attention in different industrial biotechnological processes and pharmaceutical and cosmetic industries due to their multiple properties, including antioxidant, anti-aging, anti-cancer, phycoimmunomodulatory, anti-inflammatory, and antimicrobial activities. These properties are recognized as promising components for state-of-the-art cosmetics and cosmeceutical formulations. Efforts are being made to develop natural, non-toxic, and environmentally friendly products that replace synthetic products. This review summarizes some potential cosmeceutical applications of microalgae-derived biomolecules, their mechanisms of action, and extraction methods.

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Section: Antioxidantsmentioning

confidence: 99%

Microalgae Bioactive Compounds to Topical Applications Products—A Review

et al. 2022

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“…Microalgae are preferred as fucoxanthin sources due to their superior fucoxanthin content [111]. Commercial viability in fucoxanthin production was only examined in a few microalgae strains [169]. A comprehensive screening of high fucoxanthin-producing microalgae should be adopted globally via international collaboration.…”

Section: Challenges and Possible Solutionsmentioning

confidence: 99%

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

et al. 2021

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Fucoxanthin is a major carotenoid in brown macroalgae and diatoms that possesses a broad spectrum of health benefits. This review evaluated the research trends of the fucoxanthin field from 1928 to June 2021 using the bibliometric method. The present findings unraveled that the fucoxanthin field has grown quickly in recent years with a total of 2080 publications. Japan was the most active country in producing fucoxanthin publications. Three Japan institutes were listed in the top ten productive institutions, with Hokkaido University being the most prominent institutional contributor in publishing fucoxanthin articles. The most relevant subject area on fucoxanthin was the agricultural and biological sciences category, while most fucoxanthin articles were published in Marine Drugs. A total of four research concepts emerged based on the bibliometric keywords analysis: “bioactivities”, “photosynthesis”, “optimization of process’’, and “environment”. The “bioactivities” of fucoxanthin was identified as the priority in future research. The current analysis highlighted the importance of collaboration and suggested that global collaboration could be the key to valorizing and efficiently boosting the consumer acceptability of fucoxanthin. The present bibliometric analysis offers valuable insights into the research trends of fucoxanthin to construct a better future development of this treasurable carotenoid.

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“…Carotenoid xanthophyll pigments are receiving growing interest in various industrial fields such as the functional foods industry, nutraceuticals and cosmetics, etc. [ 1 , 2 , 3 , 4 ], with an exponentially growing global market value estimated to be worth >100 millions of dollars [ 2 , 3 ]. Rapidly emerging interest in xanthophylls is due to their broad and diverse bioactive and health beneficial properties, including antioxidant, anti-inflammatory and anti-obesity [ 1 , 2 , 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Rapidly emerging interest in xanthophylls is due to their broad and diverse bioactive and health beneficial properties, including antioxidant, anti-inflammatory and anti-obesity [ 1 , 2 , 3 , 5 ]. Similarly of major interest is their anti-proliferative and anticancer activity against various cancer cell lines [ 1 , 4 , 6 ]. For these reasons, fundamental and applied research on xanthophyll pigments has increased exponentially in recent years [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Fucoxanthin (Fx, Figure 1 ) and the inter-convertible couple diadinoxanthin–diatoxanthin (Ddx+Dtx, Figure 1 ) are acknowledged as some of the most promising xanthophylls [ 3 , 4 , 6 , 8 ]. Fucoxanthin and Ddx+Dtx are mainly synthesized by representants of the stramenopile clade, within which diatoms (Bacillariophyta) comprise the most productive group [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Potential for the Production of Carotenoids of Interest in the Polar Diatom Fragilariopsis cylindrus

et al. 2022

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Carotenoid xanthophyll pigments are receiving growing interest in various industrial fields due to their broad and diverse bioactive and health beneficial properties. Fucoxanthin (Fx) and the inter-convertible couple diadinoxanthin–diatoxanthin (Ddx+Dtx) are acknowledged as some of the most promising xanthophylls; they are mainly synthesized by diatoms (Bacillariophyta). While temperate strains of diatoms have been widely investigated, recent years showed a growing interest in using polar strains, which are better adapted to the natural growth conditions of Nordic countries. The aim of the present study was to explore the potential of the polar diatom Fragilariopsis cylindrus in producing Fx and Ddx+Dtx by means of the manipulation of the growth light climate (daylength, light intensity and spectrum) and temperature. We further compared its best capacity to the strongest xanthophyll production levels reported for temperate counterparts grown under comparable conditions. In our hands, the best growing conditions for F. cylindrus were a semi-continuous growth at 7 °C and under a 12 h light:12 h dark photoperiod of monochromatic blue light (445 nm) at a PUR of 11.7 μmol photons m−2 s−1. This allowed the highest Fx productivity of 43.80 µg L−1 day−1 and the highest Fx yield of 7.53 µg Wh−1, more than two times higher than under ‘white’ light. For Ddx+Dtx, the highest productivity (4.55 µg L−1 day−1) was reached under the same conditions of ‘white light’ and at 0 °C. Our results show that F. cylindrus, and potentially other polar diatom strains, are very well suited for Fx and Ddx+Dtx production under conditions of low temperature and light intensity, reaching similar productivity levels as model temperate counterparts such as Phaeodactylum tricornutum. The present work supports the possibility of using polar diatoms as an efficient cold and low light-adapted bioresource for xanthophyll pigments, especially usable in Nordic countries.

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Bioprospecting of fucoxanthin from diatoms — Challenges and perspectives

Cited by 47 publications

References 76 publications

Microalgae Bioactive Compounds to Topical Applications Products—A Review

Microalgae Bioactive Compounds to Topical Applications Products—A Review

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

Potential for the Production of Carotenoids of Interest in the Polar Diatom Fragilariopsis cylindrus

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