Bioprospecting endophytic fungi from <i>Fusarium</i> genus as sources of bioactive metabolites

Toghueo, Rufin Marie Kouipou

doi:10.1080/21501203.2019.1645053

Cited by 109 publications

(78 citation statements)

References 154 publications

(158 reference statements)

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“…Fungal endophytes have been isolated many plant species including terrestrial plants from different parts like fruits, stems or bark, roots, leaves, tubers, buds, xylem and rachis of grasses, palms, banana, mangroves and halophytes. Fungal endophytes have been the repository of potent bioactive metabolites with diverse action including anti-cancer, antioxidant, antifungal, antibacterial, antiviral, anti-insecticidal and immunosuppressant (Tan and Zou, 2001;Toghueo, 2019). Endophytic fungi are potent source of enzyme producers.…”

Section: Discussionmentioning

confidence: 99%

Anti-Staphylococcal Potential of Fusarium Sp: Fungal Endophyte Isolated From Rauwolfia Serpentina

Gambhir¹

2020

J microb biotech food sci

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Fungal endophytes are considered as repository of potent novel bioactive compounds with profuse chemical diversity. These bioactive compounds have been widely utilized in pharmaceutical and agrochemical industries. The present work was undertaken to bio-prospect the fungal endophytes from Rauwolfia serpentina, a medicinal plant used in multiple indigenous preparations, for possible therapeutic interventions. 21 fungal endophytes were isolated from Rauwolfia serpentina with maximum colonization in leaf (42.8 %) followed by bark (33.3%) and stem (23.8%). In the enzymatic activity screening, #15RSBNEY was found to be potent amylase producer and #3RSSTNEY as potential cellulase producer. Further, three isolates viz. #16RSLBRT, #10RSLBRT and #23RSSTNEY exhibited promising antibacterial activity with maximum activity exhibited by #10RSLBRT against all test strains of Staphylococcus aureus. Interestingly, it was observed that antibacterial activity of #10RSLBRT increased by two fold after fractionation with acetone and chloroform. Based on above result, the culture filtrate of #10RSLBRT was extracted with hexane, chloroform and ethyl acetate followed by agar well gel diffusion method for antibacterial activity. The crude ethyl acetate residue of #10RSLBRT hereby exhibited potent antibacterial activity. The potential isolate i.e. #10RSLBRT was identified by molecular taxonomic tools using internal transcribed spacer rDNA analysis and was clustered in the Fusarium incarnatum-equiseti complex. Further studies on the characterization of bioactive compounds of ethyl acetate extract of # 10RSLBRT are warranted for the development of anti-staphylococcal therapy.

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Section: Discussionmentioning

confidence: 99%

Anti-Staphylococcal Potential of Fusarium Sp: Fungal Endophyte Isolated From Rauwolfia Serpentina

Gambhir¹

2020

J microb biotech food sci

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“…Cancer is a disease identified by the uncontrolled multiplication of abnormal cells which results in death in human beings when not controlled. Globally cancer prevalence is said to have increased to 9.6 million deaths and 18.1 million cases in the year 2018 (Toghueo, 2019). All over the world, those who survive cancer disease within 5 years of its detection are approximated as 43.8 million (Toghueo et al, 2019).…”

Section: Anticancer Activity and Compoundsmentioning

confidence: 99%

Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects

Fadiji

Babalola

2020

Front. Bioeng. Biotechnol.

302

193

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Endophytes are abundant in plants and studies are continuously emanating on their ability to protect plants from pathogens that cause diseases especially in the field of agriculture. The advantage that endophytes have over other biocontrol agents is the ability to colonize plant's internal tissues. Despite this attributes, a deep understanding of the mechanism employed by endophytes in protecting the plant from diseases is still required for both effectiveness and commercialization. Also, there are increasing cases of antibiotics resistance among most causative agents of diseases in human beings, which calls for an alternative drug discovery using natural sources. Endophytes present themselves as a storehouse of many bioactive metabolites such as phenolic acids, alkaloids, quinones, steroids, saponins, tannins, and terpenoids which makes them a promising candidate for anticancer, antimalarial, antituberculosis, antiviral, antidiabetic, anti-inflammatory, antiarthritis, and immunosuppressive properties among many others, even though the primary function of bioactive compounds from endophytes is to make the host plants resistant to both abiotic and biotic stresses. Endophytes still present themselves as a peculiar source of possible drugs. This study elucidates the mechanisms employed by endophytes in protecting the plant from diseases and different bioactivities of importance to humans with a focus on endophytic bacteria and fungi.

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“…It seems to have great but yet unexplored potential. The species F. culmorum is not mentioned in a comprehensive review [41] on the potential of endophytic fungi of the genus Fusarium.…”

Section: Eps Antioxidant Propertiesmentioning

confidence: 99%

Differences in Production, Composition, and Antioxidant Activities of Exopolymeric Substances (EPS) Obtained from Cultures of Endophytic Fusarium culmorum Strains with Different Effects on Cereals

et al. 2020

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Exopolymeric substances (EPS) can determine plant-microorganism interactions and have great potential as bioactive compounds. The different amounts of EPS obtained from cultures of three endophytic Fusarium culmorum strains with different aggressiveness—growth promoting (PGPF), deleterious (DRMO), and pathogenic towards cereal plants—depended on growth conditions. The EPS concentrations (under optimized culture conditions) were the lowest (0.2 g/L) in the PGPF, about three times higher in the DRMO, and five times higher in the pathogen culture. The EPS of these strains differed in the content of proteins, phenolic components, total sugars, glycosidic linkages, and sugar composition (glucose, mannose, galactose, and smaller quantities of arabinose, galactosamine, and glucosamine). The pathogen EPS exhibited the highest total sugar and mannose concentration. FTIR analysis confirmed the β configuration of the sugars. The EPS differed in the number and weight of polysaccharidic subfractions. The EPS of PGPF and DRMO had two subfractions and the pathogen EPS exhibited a subfraction with the lowest weight (5 kDa). The three EPS preparations (ethanol-precipitated EP, crude C, and proteolysed P) had antioxidant activity (particularly high for the EP-EPS soluble in high concentrations). The EP-EPS of the PGPF strain had the highest antioxidant activity, most likely associated with the highest content of phenolic compounds in this EPS.

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Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites

Cited by 109 publications

References 154 publications

Anti-Staphylococcal Potential of Fusarium Sp: Fungal Endophyte Isolated From Rauwolfia Serpentina

Anti-Staphylococcal Potential of Fusarium Sp: Fungal Endophyte Isolated From Rauwolfia Serpentina

Elucidating Mechanisms of Endophytes Used in Plant Protection and Other Bioactivities With Multifunctional Prospects

Differences in Production, Composition, and Antioxidant Activities of Exopolymeric Substances (EPS) Obtained from Cultures of Endophytic Fusarium culmorum Strains with Different Effects on Cereals

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