Bioprospecting antibiotic properties in photodynamic therapy of lipids from Codium tomemtosum and Chlorella vulgaris

Bartolomeu, Maria; Vieira, Cátia; Dias, Margarida; Conde, Tiago; Couto, Daniela; Lopes, Diana; Neves, Bruno Miguel; Melo, Tânia; Rey, Felisa; Alves, Eliana; Silva, Joana; Abreu, Helena; Almeida, Adelaide; Domingues, Rosário M.

doi:10.1016/j.biochi.2022.09.012

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Seaweeds have been a good source of bioactive molecules for various applications. Red, Brown and Green seaweeds are recently explored for various environmental, medical 38 and nutraceutical applications 39 . The present study exposed the choice of solvents for extraction, various chemical components and secondary metabolites present in the Codium tomentosum with diverse potential.…”

Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Phytochemical and Antioxidative Properties of Different Solvent Extracts of Codium tomentosum Stackhouse for Therapeutic Application

Babini,

Reena

2023

J. Drug Delivery Ther.

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Seaweeds are a phenomenal source of bioactive components in marine environments yet to be explored extensively. The study focused on estimating and identifying phytochemical components, secondary metabolites, and antioxidant efficiency of edible green seaweed Codium tomentosum (Chlorophyta). Qualitative phytochemical analysis of five solvent extracts revealed the presence of Phenol, Flavonoids, Terpenoids, Alkaloids, Tannins, Steroids, Carbohydrates, Glycosides, Amino acids and Proteins. Total phenol content (TPC) equivalent to GAE of five extracts estimated shown highest in chloroform and lowest in methanol - CE (194.53 ± 0.008 mg GAE/g) and ME (138.97 ± 0.007mg GAE/g). Total flavonoid content (TFC) quercetin equivalent (QE) was reported lowest in aqueous extract AE (59.982 ± 0.024 mg QE/g) and highest in chloroform – CE (213.07± 0.014 mg QE/g). The secondary metabolites profile of methanol extract analyzed by GC-MS revealed prominent components, Hexadecanoic acid, Flavones, Oleic acid, Dodecanoic acid, Pentadeconoic acid, and phenol derivative having a spectrum of bioactivity. In vitro, the Antioxidant activity of the five solvent extracts of Codium tomentosum was confirmed by DPPH and ABTS methods. It is evident from the present investigation that the edible green seaweed Codium tomentosum Stack House is a promising source of bioactive components that could be further explored for antimicrobial, anticancer, and antibiofilm properties through green synthesis of nanoparticles for pharmaceutical and nutraceutical applications. Keywords: Codium tomentosum, phytochemical, GC-MS, anti-oxidative, edible seaweed

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Section: Resultsmentioning

confidence: 99%

Comparative Analysis of Phytochemical and Antioxidative Properties of Different Solvent Extracts of Codium tomentosum Stackhouse for Therapeutic Application

Babini,

Reena

2023

J. Drug Delivery Ther.

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“…The identification of new antimicrobial drugs to combat antibiotic-resistance microorganisms (e.g., S. aureus, Mycobacterium tuberculosis, Pseudomonas aeruginosa) is urgently needed. The lipids identified in marine organisms have been shown to be a natural source of effective agents against a wide spectrum of microorganisms [4,56]. The lipid extracts of E. cladophorae and Z. maritima did not show antibacterial activity against E. coli ATCC 25922 (Gram-negative) and S. aureus ATCC 6538 (Gram-positive) bacteria.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lipid Extracts from the Marine Fungi Emericellopsis cladophorae and Zalerion maritima as a Source of Anti-Inflammatory, Antioxidant and Antibacterial Compounds

et al. 2023

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Marine environments occupy more than 70% of the earth’s surface, integrating very diverse habitats with specific characteristics. This heterogeneity of environments is reflected in the biochemical composition of the organisms that inhabit them. Marine organisms are a source of bioactive compounds, being increasingly studied due to their health-beneficial properties, such as antioxidant, anti-inflammatory, antibacterial, antiviral, or anticancer. In the last decades, marine fungi have stood out for their potential to produce compounds with therapeutic properties. The objective of this study was to determine the fatty acid profile of isolates from the fungi Emericellopsis cladophorae and Zalerion maritima and assess the anti-inflammatory, antioxidant, and antibacterial potential of their lipid extracts. The analysis of the fatty acid profile, using GC-MS, showed that E. cladophorae and Z. maritima possess high contents of polyunsaturated fatty acids, 50% and 34%, respectively, including the omega-3 fatty acid 18:3 n-3. Emericellopsis cladophorae and Z. maritima lipid extracts showed anti-inflammatory activity expressed by the capacity of their COX-2 inhibition which was 92% and 88% of inhibition at 200 µg lipid mL−1, respectively. Emericellopsis cladophorae lipid extracts showed a high percentage of inhibition of COX -2 activity even at low concentrations of lipids (54% of inhibition using 20 µg lipid mL−1), while a dose-dependent behaviour was observed in Z. maritima. The antioxidant activity assays of total lipid extracts demonstrated that the lipid extract from E. cladophorae did not show antioxidant activity, while Z. maritima gave an IC20 value of 116.6 ± 6.2 µg mL−1 equivalent to 92.1 ± 4.8 µmol Trolox g−1 of lipid extract in the DPPH• assay, and 101.3 ± 14.4 µg mL−1 equivalent to 106.6 ± 14.8 µmol Trolox g−1 of lipid extract in the ABTS•+ assay. The lipid extract of both fungal species did not show antibacterial properties at the concentrations tested. This study is the first step in the biochemical characterization of these marine organisms and demonstrates the bioactive potential of lipid extracts from marine fungi for biotechnological applications.

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Nonthermal high-pressure microalgae extracts: A new source of natural ingredients for cosmetics

Garcia,

Regueiras,

Lopes

et al. 2024

Algal Research

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Bioprospecting antibiotic properties in photodynamic therapy of lipids from Codium tomemtosum and Chlorella vulgaris

Cited by 4 publications

References 39 publications

Comparative Analysis of Phytochemical and Antioxidative Properties of Different Solvent Extracts of Codium tomentosum Stackhouse for Therapeutic Application

Comparative Analysis of Phytochemical and Antioxidative Properties of Different Solvent Extracts of Codium tomentosum Stackhouse for Therapeutic Application

Evaluation of Lipid Extracts from the Marine Fungi Emericellopsis cladophorae and Zalerion maritima as a Source of Anti-Inflammatory, Antioxidant and Antibacterial Compounds

Nonthermal high-pressure microalgae extracts: A new source of natural ingredients for cosmetics

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