Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms

Donnez, David; Jeandet, Philippe; Clément, Christophe; Courot, Eric

doi:10.1016/j.tibtech.2009.09.005

Cited by 186 publications

(166 citation statements)

References 63 publications

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“…Methyl jasmonate (MeJA), a jasmonic acid derivative, is one of the most effective and frequently used elicitor in secondary metabolite production. 4 MeJA plays a key role in co-ordination of plant defense gene expression. It is a signalling and regulatory molecule influencing enzymes of the biosynthetic pathway responsible for secondary metabolite synthesis.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Methyl Jasmonate on Growth and Caffeic Acid Derivative Contents of In vitro Shoot and Roots in Echinaceae (Echinacea Purpurea)

Demırcı¹,

Özmen²,

Yılmaz³

et al. 2017

IJPER

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This study was carried out to determine the effects of methyl jasmonate (MeJA) applications on growth and accumulation of caffeic acid derivatives (CADs) in shoots and roots grown in vitro. For this aim, 28 days old plants obtained from seeds were cultured in ½ Murashige and Skoog media containing different concentrations of MeJA (0, 10, 50 and 100 μM) and plants were harvested in three times at 15 days intervals. After harvest, growth parameters and CADs in shoot and roots were determined, separately. All growth parameters decreased in line with the elevating level of MeJA applications. But MeJA applications increased the CADs both shoots and roots compared to the controls. The highest cichoric acid, the main CAD of Echinacea, was found in shoots and roots applied with 100 μM MeJA and harvested in 45 days after application.

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Section: Introductionmentioning

confidence: 99%

The Influence of Methyl Jasmonate on Growth and Caffeic Acid Derivative Contents of In vitro Shoot and Roots in Echinaceae (Echinacea Purpurea)

Demırcı¹,

Özmen²,

Yılmaz³

et al. 2017

IJPER

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“…It is the most abundant stilbenoid and accumulates with the biomass in normal growth medium (Martínez-Esteso et al, 2011). When elicitors are added, resveratrol becomes highly abundant and is released into the culture medium (Morales et al, 1997;Bru et al, 2006;Donnez et al, 2009;Martínez-Esteso et al, 2009;. Cellular suspensions of Gossypium hirsutum have been developed as well for the in vitro t-R production, with values of 7.2 µg g −1 FW and also in roots of Arachis hipogea, with values of 2 µg g −1 and between 0.81 and 1.5 mg g −1 FW (Medina-Bolivar et al, 2007;Kouakou et al, 2006;Kim et al, 2008).…”

Section: Cell Aggregates From the Suspensions Culturementioning

confidence: 99%

“…(Bru et al, 2006;Santamaria et al, 2011a;2011b;Belchi-Narravo et al, 2012), Arachis hypogaea L. (Ku et al, 2005) and Gossypium hirsutum L. (Kouakou et al, 2006). The level of resveratrol is shown to depend not only on the speciesor genotype of donor plant, but also on culture conditions and type of elicitor used (Morales et al, 1998;Donnez et al, 2009;Halder and Jha, 2015;Xu et al, 2015). Of these, the highest content has been found in cellular suspensions of Vitis vinifera with values up to 1,257 mg L −1 per day (Bru et al, 2006).…”

Section: Introductionmentioning

confidence: 98%

Callus Induction and Cellular Suspensions from Murtilla (<i>Ugni molinae</i> Turcz.) for <i>trans</i>-resveratrol Production

Carolina¹,

Evelyn²,

Claudia³

et al. 2017

American Journal of Biochemistry and Biotechnology

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The present study reports for the first time the quantification of resveratrol and the use of biotechnological techniques applied to stilbene productions in species from genus Ugni and calli production from adult explants (fruits). Resveratrol is synthesized by a series of families of higher plants, which has generated much interest in recent years for its antioxidant, anticancer and antitumor properties, which would allow longevity of cells to be prolonged. In this study, leaves and mature fruits were collected from three sites in Southern Chile and correspond to three ecotypes of the Chilean endemic species Ugni molinae Turz. (murtilla). These were established in vitro to prepare the callus and subsequent development of cellular suspensions for trans-resveratrol production. Our results showed that these stilbenes are present in murtilla and that their concentrations vary between ecotypes and tissues, reaching up to 553.5 µg g −1 of t-resveratrol produced in ecotype 3 callus. These values are relatively higher than those found in other plant species. Under optimum culture conditions, extraction of resveratrol from Ugni molinae is scalable to industrial levels, which makes it a viable alternative for obtaining stilbenes.

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“…In this extraction procedure, the capacity of benzyl benzoate to extract resveratrol efficiently is essential, while the selectivity for resveratrol over structurally similar stilbenes 18 has the potential to reduce the recovery costs significantly in plant cell culture systems [40].…”

Section: Resveratrol Selectivitymentioning

confidence: 99%

Development of a liquid-liquid extraction method of resveratrol from cell culture media using solubility parameters

Balkhi

Mohammad

Tisserant

et al. 2016

Separation and Purification Technology

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The extraction of bioactive compounds, produced by plant cell cultures, directly from their culture medium, which contains other by-products, is a great challenge. Resveratrol extraction from its grapevine cell cultures is considered here as an example to optimize improve the extraction processes from plant cell cultures using solubility parameters.Successive liquid-liquid extraction (LLE) processes were exploited to extract resveratrol from the culture medium with an extraction ratio approaching 100%, high selectivity and minimum amounts of solvents. The calculations of partition coefficients as a function of solubility parameters demonstrated that benzyl benzoate is the most suitable intermediate solvent to extract resveratrol from its aqueous medium. The calculations also illustrated the high ability of methanol and ethanol to extract resveratrol from benzyl benzoate. The physicochemical properties of benzyl benzoate and processing conditions were exploited to separate it from aqueous media and organic solvents. The agitation method, component ratios and extraction time were studied to maximize the extraction yield. Under the best conditions, the recovery of resveratrol from different culture media approached ~100% with a selectivity of ~92%.2 Ultimately, the improved extraction processes of resveratrol are markedly efficient, selective, rapid and economical.

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Bioproduction of resveratrol and stilbene derivatives by plant cells and microorganisms

Cited by 186 publications

References 63 publications

The Influence of Methyl Jasmonate on Growth and Caffeic Acid Derivative Contents of In vitro Shoot and Roots in Echinaceae (Echinacea Purpurea)

The Influence of Methyl Jasmonate on Growth and Caffeic Acid Derivative Contents of In vitro Shoot and Roots in Echinaceae (Echinacea Purpurea)

Callus Induction and Cellular Suspensions from Murtilla (<i>Ugni molinae</i> Turcz.) for <i>trans</i>-resveratrol Production

Development of a liquid-liquid extraction method of resveratrol from cell culture media using solubility parameters

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