Bioprocess intensification: Cases that (don’t) work

Wielen, Luuk A. M. van der; Mussatto, Solange I.; Breugel, J. Van

doi:10.1016/j.nbt.2020.11.007

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…Driven by environmental concerns, the development of sustainable production means for the chemical industry is one of the main current challenges of process engineering [1,2] . Herein, process intensification is an outstanding tool to develop safer, more efficient, and cost‐effective processes using small devices [3–7] . To reach these goals, an interdisciplinary approach is needed, comprising (bio)catalysis, reactor engineering, reaction media, mass and heat transfer assessment, process integration, and so on.…”

Section: Introductionmentioning

confidence: 99%

“…[1,2] Herein, process intensification is an outstanding tool to develop safer, more efficient, and cost-effective processes using small devices. [3][4][5][6][7] To reach these goals, an interdisciplinary approach is needed, comprising (bio)catalysis, reactor engineering, reaction media, mass and heat transfer assessment, process integration, and so on. In this area, microreactors are gaining increasing relevance in different chemical segments, from synthesis to analytic chemistry or for ultrahigh-throughput screening purposes.…”

Section: Introductionmentioning

confidence: 99%

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Integrating Biocatalysis with Viscous Deep Eutectic Solvents in Lab‐On‐A‐Chip Microreactors

Guajardo

Marı́a²,

Canales

2022

ChemSusChem

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The combination of deep eutectic solvents (DESs, ChCl/glycerol 1 : 2) with buffer (up to 15 % v/v) leads to solvent mixtures that exert viscosities below 25 mPa s−1 at 45 °C while keeping their non‐aqueous nature. This enables the setup of efficient enzymatic esterifications, which can also be applied in different continuous systems. Following those premises, the use of microreactors in biocatalytic reactions was explored using (low‐viscous) DES‐buffer media, showing that reactions could be performed efficiently. Under non‐optimized conditions, the microreactor devices led to specific productivities considerably higher than those observed in the batch reactor (14 vs. 0.24 mgproduct min−1 mgbiocat−1) at the same enzyme loadings and conversion of 6 % (to assure a fair comparison). Looking beyond, the combination of several microchannels (e. g., in scale‐out fashion) with DES‐water media may lead to powerful, sustainable, and efficient tools for industrial synthesis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrating Biocatalysis with Viscous Deep Eutectic Solvents in Lab‐On‐A‐Chip Microreactors

Guajardo

Marı́a²,

Canales

2022

ChemSusChem

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“…Automation offers opportunities to reduce OpEx in industrial plants, 55 as here observed when comparing TPB with PAB. For TPB, a single raw material is used for inoculum production, while for PAB, five materials are required, although a significant increase in OpEx is not observed, which is justified by the reduction in the number of employees.…”

Section: Economic Indicators and Sensitivity Analysismentioning

confidence: 99%

Assessment of the Techno-Economic Feasibility of Semicontinuous Production of Metarhizium anisopliae Spores

Ferreira,

Mendes,

Thoméo

2023

Ind. Eng. Chem. Res.

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The significant increase and indiscriminate use of chemical pesticides have led to the development of several environmental problems and adverse effects on human health. Alternatively, bioinsecticides have been successfully used for a variety of crops to control several insect infestations with efficiency and competitive costs. Metarhizium anisopliae have widely been used in sugar cane crops in Brazil, and their use is the most successful enthomopathogen program worldwide. However, the production of this propagule is semiartisanal and presents several technical bottlenecks. In order to intensify this production, all the steps of the process have been revised and more efficient techniques and procedures have been adopted to avoid exogenous contamination and increase the productivity. The most relevant modification in this semicontinuous process is the cultivation of rice in packed-bed solid-state cultivation bioreactors and the extraction of spores in rotating drums, with retention of the spores in cyclones. The economic analysis showed that this process is competitive when compared with the traditional process of spore production and with similar biotechnological processes.

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“…Due to lower environmental impact, biofuels and biochemicals potentially present an attractive renewable alternative to conventional carbon sources. In this context, the focus of PSE is on multi-scale integration of processing methods for optimal functional performance of (bio) chemical manufacturing processes in a (sustainable) supply chain setting, while absorbing suitable process intensification methods within that setting (Van der Wielen et al, 2021). Thus, PSE supports optimal usage of renewable resources in several ways: integration of various components of sustainable energy systems (e.g., energy from biomass, wind, solar, etc.…”

Section: Introductionmentioning

confidence: 99%

Process systems engineering perspectives on eco-efficient downstream processing of volatile biochemicals from fermentation

Janković,

Straathof,

Kiss

2024

Front. Energy Res.

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Increasing concerns over environmental pollution, climate change and energy security are driving a necessary transition from fossil carbon sources to more sustainable alternatives. Due to lower environmental impact, biochemicals are rapidly gaining significance as a potential renewable solution, particularly of interest in Europe. In this context, process systems engineering (PSE) helps with the decision-making at multiple scales and levels, aiming for optimum use of (renewable) resources. Fermentation using waste biomass or industrial off-gases is a promising way for the production of these products. However, due to the inhibitory effects or low substrate concentrations, relatively low product concentrations can be obtained. Consequently, significant improvements in downstream processing are needed to increase the competitiveness of the overall bioprocesses. This paper supports sustainable development by providing new PSE perspectives on the purification of volatile bioproducts from dilute fermentation broths. Since purification significantly contributes to the total cost of biochemical production processes (20%–40% of the total cost), enhancing this part may substantially improve the competitiveness of the overall bioprocesses. The highly advanced downstream process offers the possibility of recovering high-purity products while enhancing the fermentation step by continuously removing inhibitory products, and recycling microorganisms with most of the present water. Besides higher productivity, the upstream process can be greatly improved by avoiding loss of biomass, enabling closed-loop operation and decreasing the need for fresh water. Applying heat pumping, heat integration and other methods of process intensification (PI) can drastically reduce energy requirements and CO2 emissions. Additionally, the opportunity to use renewable electricity instead of conventional fossil energy presents a significant step toward (green) electrification and decarbonization of the chemical industry.

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Bioprocess intensification: Cases that (don’t) work

Cited by 7 publications

References 16 publications

Integrating Biocatalysis with Viscous Deep Eutectic Solvents in Lab‐On‐A‐Chip Microreactors

Integrating Biocatalysis with Viscous Deep Eutectic Solvents in Lab‐On‐A‐Chip Microreactors

Assessment of the Techno-Economic Feasibility of Semicontinuous Production of Metarhizium anisopliae Spores

Process systems engineering perspectives on eco-efficient downstream processing of volatile biochemicals from fermentation

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