Bioprinting of Cardiac Tissues

Cheung, Daniel Y; Duan, Bin; Butcher, Jonathan T.

doi:10.1016/b978-0-12-800972-7.00021-9

Cited by 14 publications

(9 citation statements)

References 140 publications

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“…102,103 Allowing a tight control over the macroand microenvironment as well as customized shape and size, bioprinting exhibits a promising tool for the fabrication of vascularized tissue. 54,[104][105][106] However, challenges as reproducing mature tissue with an ECM composition similar to in vivo as well as inconsistent, time, material and money consuming fabrication techniques remain. 96,105,107,108 In a novel approach, Daly et al 109 demonstrated the printing of a 3D microtissue, composed of CM and fibroblast spheroids, which was able to resemble focal cardiac fibrosis for in vitro disease modelling.…”

Section: Bioprinting Of Cardiac Tissuementioning

confidence: 99%

Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models

Mohr

Thum

Bär

2022

European J of Heart Fail

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In vitro modelling the complex (patho‐) physiological conditions of the heart is a major challenge in cardiovascular research. In recent years, methods based on three‐dimensional (3D) cultivation approaches have steadily evolved to overcome the major limitations of conventional adherent two‐dimensional (2D) monolayer cultivation. These 3D approaches aim to study, reproduce or modify fundamental native features of the heart such as tissue organization and cardiovascular microenvironment. Therefore, these systems have great potential for (patient‐specific) disease research, for the development of new drug screening platforms, and for the use in regenerative and replacement therapy applications. Consequently, continuous improvement and adaptation is required with respect to fundamental limitations such as cardiomyocyte maturation, scalability, heterogeneity, vascularization, and reproduction of native properties. In this review, 2D monolayer culturing and the 3D in vitro systems of cardiac spheroids, organoids, engineered cardiac microtissue and bioprinting as well as the ex vivo technique of myocardial slicing are introduced with their basic concepts, advantages, and limitations. Furthermore, recent advances of various new approaches aiming to extend as well as to optimize these in vitro and ex vivo systems are presented.

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Section: Bioprinting Of Cardiac Tissuementioning

confidence: 99%

Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models

Mohr

Thum

Bär

2022

European J of Heart Fail

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“… 14,92 Neovascularization is indeed a necessity for the stable survivability and functioning of an engraftment. 15 Following MI aftermath, both myocardial tissues and vasculatures are equally and severely damaged; therefore, therapeutic or regenerative approaches should be planned to target both of them concurrently to achieve a successful cardiac repair. 93 Employing a 3D bioprinting strategy to geometrically control the spatial patterning and using dual stem cell therapy or its co-culture can play an important role in promoting and synergistically improving vascularization as well as cardiac function following MI.…”

Section: Bioprinted Stem Cell-laden Cardiac Patchmentioning

confidence: 99%

“… 8 Although the detailed mechanisms are insufficiently addressed, it is believed that paracrine signaling essentially takes part in cell-mediated tissue repair. 19–21 Nevertheless, there are several caveats to cell-based therapies, and their clinical impact is severely hampered by (1) a low rate of cell retention or engraftment after delivery, 22 (2) a low viability of injected cells, 15 (3) an insufficient oxygen and nutrient supply, and (4) a lack of proper integration with the recipient's tissue. 23 Moreover, with continuous attempts to identify the optimal cell types, interest has also shifted toward adult or pluripotent stem cells.…”

Section: Introductionmentioning

confidence: 99%

“… 13 In particular, cardiac tissue engineering endeavors to mimic the native microenvironment of the host cardiac tissue using biocompatible materials loaded with living cells, bioactive molecules, and various stimulating factors. 15,16 The most widely applicable biocompatible material is a biodegradable polymer, especially for the construction of 3D-structured tissues and organs. However, the synthetic biodegradable polymers are usually rigid to support the dynamic motion of cardiovascular tissues and difficult to be remodeled by the cells, resulting in a gradual decrease in the number of intercellular connections.…”

Section: Introductionmentioning

confidence: 99%

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3D bioprinting of stem cell-laden cardiac patch: A promising alternative for myocardial repair

2021

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Stem cell-laden three-dimensional (3D) bioprinted cardiac patches offer an alternative and promising therapeutic and regenerative approach for ischemic cardiomyopathy by reversing scar formation and promoting myocardial regeneration. Numerous studies have reported using either multipotent or pluripotent stem cells or their combination for 3D bioprinting of a cardiac patch with the sole aim of restoring cardiac function by faithfully rejuvenating the cardiomyocytes and associated vasculatures that are lost to myocardial infarction. While many studies have demonstrated success in mimicking cardiomyocytes' behavior, improving cardiac function and providing new hope for regenerating heart post-myocardial infarction, some others have reported contradicting data in apparent ways. Nonetheless, all investigators in the field are speed racing toward determining a potential strategy to effectively treat losses due to myocardial infarction. This review discusses various types of candidate stem cells that possess cardiac regenerative potential, elucidating their applications and limitations. We also brief the challenges of and an update on the implementation of the state-of-the-art 3D bioprinting approach to fabricate cardiac patches and highlight different strategies to implement vascularization and augment cardiac functional properties with respect to electrophysiological similarities to native tissue.

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“…The electrical signals mainly depend on the voltage-gated calcium channels of the cell membrane, and are converted into mechanical responses through an ECC process [146,148]. Engineered cardiac constructs also contract spontaneously, but at varying rates, and with some irregularity over time [173]. This arrhythmia risk can in turn lead to implantation failure [15].…”

Section: D Bioprinting Of the Cardiovascular Systemmentioning

confidence: 99%

3D bioprinting for cardiovascular regeneration and pharmacology

Cui

Miao

Esworthy

et al. 2018

Advanced Drug Delivery Reviews

138

116

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Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Compared to traditional therapeutic strategies, three-dimensional (3D) bioprinting is one of the most advanced techniques for creating complicated cardiovascular implants with biomimetic features, which are capable of recapitulating both the native physiochemical and biomechanical characteristics of the cardiovascular system. The present review provides an overview of the cardiovascular system, as well as describes the principles of, and recent advances in, 3D bioprinting cardiovascular tissues and models. Moreover, this review will focus on the applications of 3D bioprinting technology in cardiovascular repair/regeneration and pharmacological modeling, further discussing current challenges and perspectives.

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Bioprinting of Cardiac Tissues

Cited by 14 publications

References 140 publications

Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models

Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models

3D bioprinting of stem cell-laden cardiac patch: A promising alternative for myocardial repair

3D bioprinting for cardiovascular regeneration and pharmacology

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