Bioprinting for bone tissue engineering

Kang, Xin; Zhang, Xiaobo; Gao, Xi-Dan; Hao, Ding-Jun; Li, Tao; Zhou, Xu

doi:10.3389/fbioe.2022.1036375

Cited by 12 publications

(7 citation statements)

References 41 publications

(41 reference statements)

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“…The biggest highlight of this study is the pioneering advancement in the development of biomaterials for bone repair [ 39 ]. Building upon the previously established physicochemical and bioactive microenvironment PCI3D functional modules [ 9 ], we utilized 3D printing to construct bone repair functional modules with metabolic functions.…”

Section: Discussionmentioning

confidence: 99%

The Osteocyte with SB216763-Activated Canonical Wnt Signaling Constructs a Multifunctional 4D Intelligent Osteogenic Module

Zhang,

Chen

et al. 2024

Biomolecules

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The enhancement of bioactivity in materials has become an important focus within the field of bone tissue engineering. Four-dimensional intelligent osteogenic module, an innovative fusion of 3D printing with the time axis, shows immense potential in augmenting the bioactivity of these materials, thereby facilitating autologous bone regeneration efficiently. This study focuses on novel bone repair materials, particularly bioactive scaffolds with a developmental osteogenic microenvironment prepared through 3D bioprinting technology. This research mainly creates a developmental osteogenic microenvironment named “DOME”. This is primed by the application of a small amount of the small molecule drug SB216763, which activates canonical Wnt signaling in osteocytes, promoting osteogenesis and mineralization nodule formation in bone marrow stromal cells and inhibiting the formation of adipocytes. Moreover, DOME enhances endothelial cell migration and angiogenesis, which is integral to bone repair. More importantly, the DOME-PCI3D system, a 4D intelligent osteogenic module constructed through 3D bioprinting, stably supports cell growth (91.2% survival rate after 7 days) and significantly increases the expression of osteogenic transcription factors in bone marrow stromal cells and induces osteogenic differentiation and mineralization for 28 days. This study presents a novel approach for bone repair, employing 3D bioprinting to create a multifunctional 4D intelligent osteogenic module. This innovative method not only resolves challenges related to shape-matching and biological activity but also demonstrates the vast potential for applications in bone repair.

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Section: Discussionmentioning

confidence: 99%

The Osteocyte with SB216763-Activated Canonical Wnt Signaling Constructs a Multifunctional 4D Intelligent Osteogenic Module

Zhang,

Chen

et al. 2024

Biomolecules

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“…Currently, scientists are conducting research on 4D-printed biomaterials in a few applications. This includes the production of functional meniscal implants [ 82 ], regeneration of cartilage with chitosan derivatives [ 83 ], bone replacement implants for treating losses caused by trauma or genetic diseases [ 84 , 85 , 86 , 87 ], and tooth implants [ 88 ]. Additionally, there is evidence of the potential usage of 4D-printed biomaterials in the engineering of the cardiovascular system.…”

Section: 3d Cell Culturesmentioning

confidence: 99%

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Górnicki,

Lambrinow,

Golkar-Narenji

et al. 2024

Nanomaterials

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Biomimetic scaffolds imitate native tissue and can take a multidimensional form. They are biocompatible and can influence cellular metabolism, making them attractive bioengineering platforms. The use of biomimetic scaffolds adds complexity to traditional cell cultivation methods. The most commonly used technique involves cultivating cells on a flat surface in a two-dimensional format due to its simplicity. A three-dimensional (3D) format can provide a microenvironment for surrounding cells. There are two main techniques for obtaining 3D structures based on the presence of scaffolding. Scaffold-free techniques consist of spheroid technologies. Meanwhile, scaffold techniques contain organoids and all constructs that use various types of scaffolds, ranging from decellularized extracellular matrix (dECM) through hydrogels that are one of the most extensively studied forms of potential scaffolds for 3D culture up to 4D bioprinted biomaterials. 3D bioprinting is one of the most important techniques used to create biomimetic scaffolds. The versatility of this technique allows the use of many different types of inks, mainly hydrogels, as well as cells and inorganic substances. Increasing amounts of data provide evidence of vast potential of biomimetic scaffolds usage in tissue engineering and personalized medicine, with the main area of potential application being the regeneration of skin and musculoskeletal systems. Recent papers also indicate increasing amounts of in vivo tests of products based on biomimetic scaffolds, which further strengthen the importance of this branch of tissue engineering and emphasize the need for extensive research to provide safe for humansbiomimetic tissues and organs. In this review article, we provide a review of the recent advancements in the field of biomimetic scaffolds preceded by an overview of cell culture technologies that led to the development of biomimetic scaffold techniques as the most complex type of cell culture.

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“…FDM, DIW, SLA, and IJP are applied to print intricate structures. [ 572 ] However, filaments for FDM are limited, whereas SLA requires photocurable liquid resins, and DIW requires feedstock in a liquid form. Additionally, inks suitable for DIW must meet the requirements of tunable rheology and high swelling degree.…”

Section: Current Challenges and Future Outlookmentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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Bioprinting for bone tissue engineering

Cited by 12 publications

References 41 publications

The Osteocyte with SB216763-Activated Canonical Wnt Signaling Constructs a Multifunctional 4D Intelligent Osteogenic Module

The Osteocyte with SB216763-Activated Canonical Wnt Signaling Constructs a Multifunctional 4D Intelligent Osteogenic Module

Biomimetic Scaffolds—A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

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