Bioprinting: An Industrial Perspective

Roskos, Kristina; Stuiver, Ingrid; Pentoney, Steve; Presnell, Sharon C.

doi:10.1016/b978-0-12-800972-7.00024-4

Cited by 6 publications

(3 citation statements)

References 68 publications

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“…Use of a single material in bioprinting can be advantageous for isolating biological responses when elucidating cell-material interactions for tissue engineering studies. The use of fewer materials in the bioink formulation also minimizes precursor processing and preparation and facilitates the future translation of any promising biomedical therapies, as there would be fewer materials required to meet the stringent manufacturing quality control procedures necessary for regulatory approval Table outlines the single-material bioprinting studies that utilize cell-encapsulating, single-polymer biodegradable bioinks (labeled “SB”) that were introduced in the previous section.…”

Section: Polymeric Materials-based Approaches To Bioprinting Tissues ...mentioning

confidence: 99%

Polymeric Systems for Bioprinting

et al. 2020

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Bioprinting is rapidly being adopted as a major method for fabricating tissue engineering constructs. Through the precise deposition of cell- and bioactive molecule-laden materials, bioprinting offers researchers a means to create biological constructs with enhanced spatial complexity that more closely mimics native tissue. The vast majority of materials used in bioprinting have been polymers due to their suitability toward resembling the cellular environment and the variety of methods available to process polymeric systems in ambient or relatively mild chemical and environmental conditions. In this review, we will discuss in detail the wide variety of natural and synthetic polymers that have been employed as inks in bioprinting. We will review recent bioprinting innovations, such as increasing architectural complexity and cell viability in heterogeneous tissue constructs, which allow for the investigation of biological questions that could not be addressed before. We will also survey nascent fields of study that promise to further advance the development of novel biofabrication technologies in the field, such as 4D bioprinting and the inclusion of nanomaterials. To conclude, we will examine some of the necessary steps that must take place to bring this technology to commercial markets and facilitate its use in clinical therapies.

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Section: Polymeric Materials-based Approaches To Bioprinting Tissues ...mentioning

confidence: 99%

Polymeric Systems for Bioprinting

et al. 2020

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“…In November 2014, Organovo began offering its 3D-printed exVive3D liver tissue models to screen drugs for liver toxicity. A scaffold-free tissue bioprinting approach was performed using NovoGen MMX Bioprinter, where pellets of co-cultured human hepatocytes, hepatic stellate and endothelial cells were bioprinted into a temporary mold structure with building units in a hexagonal shape (Figure 5c1) [90]. After bioprinting, cells further aggregated and the tissue construct matured toward a native-like tissue model (Figure 5c2), which maintains normal function for at least 42 days.…”

Section: Pharmaceutics and High-throughput Screeningmentioning

confidence: 99%

“…Liver HepG2 [82,83]; epithelial cells and hepatocytes [5]; human hepatocytes, hepatic satellite cells and endothelial cells [90] Alginate [82,83]; Matrigel [5]; cell pellet [90] Extrusion-based (valve) [5,82,83]; extrusionbased (mechanical) [90] Multi-nozzle system , [5,82,83]; NovoGen MMX Bioprinter [90] Bioprinted liver tissue models have a great potential in early drug discovery but a standard model is yet to be developed…”

Section: Pharmaceutics and Drug Testingmentioning

confidence: 99%

Application areas of 3D bioprinting

Özbolat

Peng

Özbolat

2016

Drug Discovery Today

274

158

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Three dimensional (3D) bioprinting has been a powerful tool in patterning and precisely placing biologics, including living cells, nucleic acids, drug particles, proteins and growth factors, to recapitulate tissue anatomy, biology and physiology. Since the first time of cytoscribing cells demonstrated in 1986, bioprinting has made a substantial leap forward, particularly in the past 10 years, and it has been widely used in fabrication of living tissues for various application areas. The technology has been recently commercialized by several emerging businesses, and bioprinters and bioprinted tissues have gained significant interest in medicine and pharmaceutics. This Keynote review presents the bioprinting technology and covers a first-time comprehensive overview of its application areas from tissue engineering and regenerative medicine to pharmaceutics and cancer research.

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The Changing Face of Biological Research and the Growing Role of Biosecurity

Dunaway¹,

Berger

2021

Advanced Sciences and Technologies for Security Applications

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Bioprinting: An Industrial Perspective

Cited by 6 publications

References 68 publications

Polymeric Systems for Bioprinting

Polymeric Systems for Bioprinting

Application areas of 3D bioprinting

The Changing Face of Biological Research and the Growing Role of Biosecurity

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