Biopolymers and polymers in the search of alternative treatments for meniscal regeneration: State of the art and future trends

Murphy, Caroline A.; Costa, João B.; Silva‐Correia, Joana; Oliveira, Joaquím M.; Reis, Rui L.; Collins, Maurice N.

doi:10.1016/j.apmt.2018.04.002

Cited by 82 publications

(54 citation statements)

References 187 publications

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“…The blood-brain barrier (BBB) has a special structure that separates the extracellular fluid of neurons from blood circulation [23][24][25][26][27][28][29]. Paul Ehrlich gave the first evidence for the presence of BBB in his research in 1885 [30].…”

Section: The Blood-brain Barrier (Bbb)mentioning

confidence: 99%

“…Gelatin (GE) is a by-product of denatured and partially hydrolyzed collagen, which is extensively used in tissue engineering and therapeutic delivery [234,235]. Also, GE has bioactive materials such as arginine-glycine-aspartic acid, which gives GE a cell attachment property and makes GE valuable as a biomaterial [28,[236][237][238][239][240][241]. At present, GE and its blends are used in the food industry and in medical products [242,243].…”

Section: Gelatin (Ge)mentioning

confidence: 99%

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Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

et al. 2020

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The blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.

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Section: The Blood-brain Barrier (Bbb)mentioning

confidence: 99%

Section: Gelatin (Ge)mentioning

confidence: 99%

Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

et al. 2020

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“…The ease of modifying the HA backbone with functional groups, such as hydrophobic moieties or cross-linkable groups, enables obtaining printable hydrogels (Kesti et al, 2015;Loebel et al, 2017). Therefore, thanks to the addition of HA, the bioink viscosity can be increased to allow for continuous extrusion of hydrogel strands (Murphy et al, 2018). The most recent attempt is by Loebel et al 2017, who developed a self-assembling HA hydrogel based on GH hydrophobic interactions of conjugated groups, Ad (guest) and CD (host).…”

Section: Hydrophobic Ha Derivativesmentioning

confidence: 99%

“…Further, this copolymer hydrogel supports alveolar cell adhesion and growth and is suitable for the adhesion and proliferation of multiple cell types (Radhakumary et al, 2011). For meniscal regeneration, MSCs in a hyaluronan-collagen scaffold display good healing potential with the development of integrated meniscus-like repair tissue (Murphy et al, 2018). Furthermore, the implantation of eEPCs encapsulated in HyStem ® matrix demonstrates improved resistance to toxic insult (adriamycin) in vitro, eEPC mobilisation to injured kidneys and improved renal function (Ratliff et al, 2010).…”

Section: Cardiac Tementioning

confidence: 99%

dvances of hyaluronic acid in stem cell therapy and tissue engineering, including current clinical trials

López‐Ruiz¹,

Jiménez²,

Cienfuegos³

et al. 2019

eCM

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Hyaluronic acid (HA), as one of the main components of the extracellular matrix (ECM), plays a significant role in a multitude of biological processes involving cell migration, proliferation, differentiation, wound healing and inflammation. Thanks to its excellent biocompatibility, biodegradability and hygroscopic properties, HA has been used in its natural form for joint lubrication and ocular treatment. The chemical structure of HA can be easily modified by direct reaction with its carboxyl and hydroxyl groups. Recently, HA derivatives have been synthesised with the aim of developing HA-based materials with increased mechanical strength, improved cell interactions and reduced biodegradation and studied for regenerative medicine purposes, including cell therapy and tissue engineering. In this context, the present manuscript reviews HA applications from a basic point of view-including chemical modifications and cellular biology aspects related to clinical translation-and future perspectives of using biofabrication technologies for regenerative medicine. A detailed description of current clinical trials, testing advanced therapies based on combination of stem cells and HA formulations, is included. The final goal was to offer an integral portrait and a deeper comprehension of the current applications of HA from bench to bedside.

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“…The main steps involved in meniscus tissue engineering are preparing a scaffold and seeding cells and regulating the cell-scaffold construct through cytokines, mechanical stimulation, and other methods to synthesize the extracellular matrix (ECM) in vitro, followed by its transplantation in vivo for meniscus regeneration and function [4]. 3D printing technology can fabricate scaffolds with complete control of size, shape, and porosity; it has been used in many previous studies to prepare tissue-engineered meniscus scaffolds [5][6][7][8]. Bone marrow mesenchymal stem cells (BMSCs) are easy to isolate and proliferate, have low immunogenicity, and potential to differentiate into cartilage; thus, they have become ideal seed cell for meniscus tissue engineering [9,10].…”

Section: Introductionmentioning

confidence: 99%

Parathyroid hormone (1-34) promotes the effects of 3D printed scaffold-seeded bone marrow mesenchymal stem cells on meniscus regeneration

Zhao

Zou

Cui

et al. 2020

Preprint

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Abstract Background: Cell-based tissue engineering represents a promising management for meniscus repair and regeneration. The present study aimed to investigate whether the injection of parathyroid hormone (PTH) (1-34) could promote the regeneration and chondroprotection of 3D printed scaffold seeded with bone marrow mesenchymal stem cells (BMSCs) in a canine total meniscal meniscectomy model. Methods: 3D printed poly(e-caprolactone) scaffold seeded with BMSCs was cultured in vitro, and the effects of in vitro culture time on cell growth and matrix synthesis of the BMSCs-scaffold construct were evaluated by microscopic observation and cartilage matrix content detection at 7, 14, 21, and 28 days. After that, the tissue-engineered meniscus based on BMSCs–scaffold cultured for the appropriate culture time was selected for in vivo implantation. Sixteen dogs were randomly divided into four groups: PTH + BMSCs–scaffold, BMSCs–scaffold, total meniscectomy, and sham operation. The regeneration of the implanted tissue and the degeneration of articular cartilage were assessed by gross, histological, and immunohistochemical analysis at 12 weeks postoperatively.Results: In vitro study showed that the glycosaminoglycan (GAG)/DNA ratio and the expression of collagen type II (Col2) were significantly higher on day 21 as compared to the other time points. In vivo study showed that, compared with the BMSCs–scaffold group, the PTH + BMSCs–scaffold group showed better regeneration of the implanted tissue and greater similarity to native meniscus concerning gross appearance, cells composition, and cartilage extracellular matrix deposition. This group also showed less expression of terminal differentiation markers of BMSC chondrogenesis as well as lower cartilage degeneration with less damage on the knee cartilage surface, higher expression of Col2, and lower expression of degeneration markers.Conclusions: Our results demonstrated that PTH (1-34) promotes the regenerative and chondroprotective effects of the BMSCs–3D printed meniscal scaffold in a canine model, and thus their combination could be a promising strategy for meniscus tissue engineering.

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Biopolymers and polymers in the search of alternative treatments for meniscal regeneration: State of the art and future trends

Cited by 82 publications

References 187 publications

Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

Multifunctional Polymeric Nanoplatforms for Brain Diseases Diagnosis, Therapy and Theranostics

dvances of hyaluronic acid in stem cell therapy and tissue engineering, including current clinical trials

Parathyroid hormone (1-34) promotes the effects of 3D printed scaffold-seeded bone marrow mesenchymal stem cells on meniscus regeneration

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