Biopolymeric nanoparticles

Sundar, S. Shanmuga; Kundu, Joydip; Kundu, Subhas C.

doi:10.1088/1468-6996/11/1/014104

Cited by 277 publications

(171 citation statements)

References 169 publications

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“…The resulting suspension was vacuum-filtered, and the product was freeze-dried. The obtained nCHA powder had a CO 2− 3 content of 8.0 ± 0.3% (determined by CHN Elemental Microanalysis) and a high specific surface area of 120 m 2 g −1 ; it was composed of nanocrystals (15)(16)(17)(18)(19)(20) × (3-5 nm) in size. We used the following polymers: agarose (Agarose for routine use, Sigma-Aldrich, Steinheim, Germany) and gellan (Gelrite Gellan Gum powder, Sigma-Aldrich, Steinheim, Germany).…”

Section: Methodsmentioning

confidence: 99%

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Control of the pore architecture in three-dimensional hydroxyapatite-reinforced hydrogel scaffolds

Román

Cabañas

Peña

et al. 2011

Science and Technology of Advanced Materials

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Hydrogels (gellan or agarose) reinforced with nanocrystalline carbonated hydroxyapatite (nCHA) were prepared by the GELPOR3D technique. This simple method is characterized by compositional flexibility; it does not require expensive equipment, thermal treatment, or aggressive or toxic solvents, and yields a three-dimensional (3D) network of interconnected pores 300-900 µm in size. In addition, an interconnected porosity is generated, yielding a hierarchical porous architecture from the macro to the molecular scale. This porosity depends on both the drying/preservation technology (freeze drying or oven drying at 37• C) and on the content and microstructure of the reinforcing ceramic. For freeze-dried samples, the porosities were approximately 30, 66 and below 3% for pore sizes of 600-900 µm, 100-200 µm and 50-100 nm, respectively. The pore structure depends much on the ceramic content, so that higher contents lead to the disappearance of the characteristic honeycomb structure observed in low-ceramic scaffolds and to a lower fraction of the 100-200-µm-sized pores. The nature of the hydrogel did not affect the pore size distribution but was crucial for the behavior of the scaffolds in a hydrated medium: gellan-containing scaffolds showed a higher swelling degree owing to the presence of more hydrophilic groups.

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Section: Methodsmentioning

confidence: 99%

“…Nature shows several examples of lightweight, high-performance structural materials with outstanding strength and toughness [12]. In this sense, biology has long developed the ability to combine brittle minerals and organic molecules into hybrid composites with exceptional fracture resistance and structural capability [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Control of the pore architecture in three-dimensional hydroxyapatite-reinforced hydrogel scaffolds

Román

Cabañas

Peña

et al. 2011

Science and Technology of Advanced Materials

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“…Although both the formation of complexes with macromolecules and coacervates with small inorganic cations are based on ionic interaction, the macromolecular complexes possess additional macromolecular chain physical entanglement properties that are much stronger than other secondary binding mechanisms, such as hydrogen bonding and van der Waals interactions. A group of second polymers, including D-glucono-δ-lactone, polyols, chitosan, and polycationic polymers, have been used to obtain alginate/Ca ++ beads with a more even structure by altering the cross-linking process [8,[12][13][14][15]. Among these polymers, chitosan has gained increased attention as a safe and active component in the preparation of drug delivery systems.…”

Section: Alginate and Alginate/chitosanmentioning

confidence: 99%

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

et al. 2012

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Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention. The inclusion of a second biopolymer strengthens the stability of resultant hydrogels and enriches its functionalities by bringing in new functional groups or optimizing the micro-environmental conditions for certain biological and biochemical processes. This article presents approaches that have been used by our groups to synthesize biopolymer hybrid hydrogels for effective uses for immunotherapy, tissue regeneration, food and functional food applications. The research has achieved some challenging results, such as stabilizing physical structure, increasing mucoadhesiveness, and the creation of an artificial extracellular matrix to aid in guiding tissue differentiation.

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“…The aqueous phase consists of hydrophilic surfactant and water, whereas the organic phase is a homogeneous solution of lipophilic surfactant, oil and water-miscible solvent. At the end of the reaction, PNPs with very small droplets (50-100 nm) will form [23]. It is known that this method requires large amounts of surfactant/co-surfactant to make small NPs which increases cost and causes difficulty of purification [8].…”

Section: Recent Development In Synthesis Of Pnpsmentioning

confidence: 99%

Polymeric nanoparticles: Recent development in synthesis and application

Mallakpour¹,

Behranvand²

2016

Express Polym. Lett.

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Abstract. Nanosized particles have attractive characteristics, which have received considerable attention in the last decade. Polymeric nanoparticles (PNP)s are solid particles or particulate dispersions with size in the range of 10-1000 nm. Due to the very small size, the surface area is very large so the percentage of atoms or molecules on the surface is significantly increased, which is expected to have extensive applications in various fields such as drug delivery systems, biosensors, catalysts, nanocomposites, agriculture and environment. The aim of the present paper is to critically review enhancement in the field of synthesis and different application of novel PNPs in various area from drug delivery to composite fabrication. Literature sources were mainly taken from the publications of 2011 and later; though, for a basic depiction of the structural principles, older publications have also been cited. Vol.10, No.11 (2016) 895-913 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2016.84 * Corresponding author, e-mail: mallak@cc.iut.ac.ir © BME-PT of these methods as low cost and safe ways should be highlighted. Furthermore, their importance according to their applications discusses. We will also show some properties of them such as morphology and biological activity. Keywords: biopolymers, biocomposites, polymeric nanoparticles, drug delivery systems, biosensors eXPRESS Polymer Letters

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Biopolymeric nanoparticles

Cited by 277 publications

References 169 publications

Control of the pore architecture in three-dimensional hydroxyapatite-reinforced hydrogel scaffolds

Control of the pore architecture in three-dimensional hydroxyapatite-reinforced hydrogel scaffolds

Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications

Polymeric nanoparticles: Recent development in synthesis and application

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