Biopolymer nanoparticles as potential delivery systems for anthocyanins: Fabrication and properties

Arroyo‐Maya, Izlia J.; McClements, David Julian

doi:10.1016/j.foodres.2014.12.005

Cited by 162 publications

(65 citation statements)

References 48 publications

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“…Oral delivery of drug is the most patient friendly with highest compliance. Recently, alginate-based in situ gastroretentive gelling [58] and microencapsulation with maltodextrin, whey protein isolate and beet pectin [59–61] systems are explored to increase stability, modulate the release and increase the retention time of anthocyanins.…”

Section: Discussionmentioning

confidence: 99%

Exosomal formulation of anthocyanidins against multiple cancer types

et al. 2017

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Over the last two decades, berries and berry bioactives, particularly anthocyanins and their aglycones anthocyanidins (Anthos) have demonstrated excellent anti-oxidant, anti-proliferative, apoptotic and anti-inflammatory properties. However, their physicochemical and pharmacokinetic limitations such as, low permeability, and poor oral bioavailability are considered as unfavorable properties for development as drugs. Therefore there is a need to develop systems for efficient systemic delivery and robust bioavailability. In this study we prepared nano-formulation of bilberry-derived Anthos using exosomes harvested from raw bovine milk. Exosomal formulation of Anthos enhanced antiproliferative and anti-inflammatory effects compared with the free Anthos against various cancer cells in vitro. Our data also showed significantly enhanced therapeutic response of exosomal-Anthos formulation compared with the free Anthos against lung cancer tumor xenograft in nude mice. The Anthos showed no signs of gross or systemic toxicity in wild-type mice. Thus, exosomes provide an effective alternative for oral delivery of Anthos that is efficacious, cost-effective, and safe, and this regimen can be developed as a non-toxic, widely applicable therapeutic agent.

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Section: Discussionmentioning

confidence: 99%

Exosomal formulation of anthocyanidins against multiple cancer types

et al. 2017

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“…It can probably attribute to the fact that the produced GPC particles had minimum size at this pH due to formation of maximum electrostatic interactions between protein and polysaccharide (Sarika et al, ), which led to reduction of particle size and formation of inter‐polymeric complexes. Arroyo‐Maya and McClements () reported that the mean diameter of the whey protein isolated‐pectin particles increased appreciably at very low or high values of pH, so that the particles with the size of less than 200 nm at pH 4 grew to above 450 nm around pH 3 and 5.…”

Section: Resultsmentioning

confidence: 99%

“…Modification of texture, stabilization of food emulsions and suspensions, production of specific hydrocolloid gels and encapsulation and protection of bioactive ingredients are some of protein–polysaccharide complex applications in various industries. The encapsulation of bioactive compounds may exert different benefits, for example, protection from several damaging environmental factors, such as light, oxygen, moisture, heat, mechanical stresses, or other destructive agents (Arroyo‐Maya & McClements, ; Devi et al, ), controlling the release of bioactives within foods during storage and also in human gastrointestinal tract, increase in solubility in aqueous foods and covering unfavorable flavor and odor of bioactive ingredients.…”

Section: Introductionmentioning

confidence: 99%

Design, fabrication and characterization of pectin-coated gelatin nanoparticles as potential nano-carrier system

et al. 2018

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The main purpose of this study was to fabricate potential nano‐delivery systems based on protein–polysaccharide complex for use in beverages. In this regard, optimum gelatin–pectin complex (GPC) nano‐carrier with hydrodynamic diameter of ≈200 nm was designed and fabricated using low‐bloom gelatin (BG) and high‐methoxyl pectin (CP) at BG/CP weight ratio of 1:1 (0.025%(w/v) CP on 0.025%(w/v) BG) and pH 4.5. The suspension containing GPC nano‐carrier had very good transparency (14.1NTU). Scanning electron microscopy (SEM) images illustrated that the GPC particles were spherical with fairly smooth surface. Particle size analysis showed that the complex particles had a narrow size distribution (polydispersity index (PDI)≈0.254). Fourier transform infrared (FTIR) confirmed the formation of amide bonds between carboxyl groups in CP and amino groups in BG, and differential scanning calorimetry (DSC) analysis showed the amorphous nature of the GPC nano‐carrier. Finally, the storage stability test indicated that the GPC particles didn't significantly grow after 20 days of storage at 4°C. Practical application The encapsulation of bioactive compounds have different benefits, for example, protection from several damaging environmental factors such as light, oxygen, moisture, heat, mechanical stresses, or other destructive agents, controlling the release of bioactives within foods during storage and also in human gastrointestinal tract, increase in solubility in aqueous foods and covering unfavorable flavor and odor of bioactive ingredients. So that, development of this technic can develops new functional, healthy foods, and foods with new tastes.

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“…Thus, a low‐dose of E‐PNs is an alternative to CPE in health food and pharmaceutical research. Previous researches have also demonstrated that encapsulating bioactive compounds with nanoparticles could protect them from undesirable conditions and improved their antioxidant activity (Harris et al ., ; Tzeng et al ., ; Arroyo‐Maya & McClements, ).…”

Section: Resultsmentioning

confidence: 99%

In vitro release and antioxidant activity of Satsuma mandarin (Citrus reticulata Blanco cv. unshiu) peel flavonoids encapsulated by pectin nanoparticles

Zhang

et al. 2017

Int J of Food Sci Tech

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The flavonoids of citrus peel extracts (CPE) were encapsulated by pectin nanoparticles (PNs), in an attempt to control the releasing property and improve their antioxidant activity. The physiochemical properties of the obtained PNs were characterised. Flavonoid composition in CPE before and after encapsulation were determined. In vitro release profiles and antioxidant activity of CPE were further evaluated. Results showed the size of spherical PNs obtained was 271.5 AE 5.3 nm. Interestingly, in simulated gastric fluid (SGF), 73% flavonoids were released from the naked CPE after 2 h, while only 28.78% from the CPE-loaded PNs (E-PNs). The releasing rate of flavonoids reached 91.47% from E-PNs after 24 h in the simulated intestinal fluid (SIF). Moreover, DPPH and ABTS assay revealed that E-PNs showed higher antioxidant activity than blank PNs and free CPE. These data showed that the controlled release of CPE might potentially increase its bioaccessibility and there was a synergistic effect between citrus PNs and CPE on the antioxidant activity. Encapsulation, release, antioxidant activity Y. Hu et al. Encapsulation, release, antioxidant activity Y. Hu et al.Figure 6 Comparison of antioxidant activity of CPE by DPPH• + (a) and ABTS• + (b) and antioxidant activity of E-PNs and pectin by DPPH• + (c) and ABTS• + (d) at different concentrations, data are reported as means AE SD, n = 3. Encapsulation, release, antioxidant activity Y. Hu et al.

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Biopolymer nanoparticles as potential delivery systems for anthocyanins: Fabrication and properties

Cited by 162 publications

References 48 publications

Exosomal formulation of anthocyanidins against multiple cancer types

Exosomal formulation of anthocyanidins against multiple cancer types

Design, fabrication and characterization of pectin-coated gelatin nanoparticles as potential nano-carrier system

In vitro release and antioxidant activity of Satsuma mandarin (Citrus reticulata Blanco cv. unshiu) peel flavonoids encapsulated by pectin nanoparticles

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