Biopolymer membranes in tissue engineering

Silva, Simone S.; Rodrigues, L. C.; Fernandes, Emanuel M.; Reis, Rui L.

doi:10.1016/b978-0-12-818134-8.00006-7

Cited by 4 publications

(3 citation statements)

References 81 publications

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“…CHT has a structure composed of repeating units of N-acetyl-2-amino-2-deoxy-d-glucopyranose (acetylated unit) and 2-amino-2-deoxy-glucopyranose (deacetylated unit), which are linked by β-(1→4)-glycosidic bonds [3]. It displays interesting physical, structural, and chemical features, which result in film-forming ability, antibacterial action, biocompatibility, and biodegradability [3,7,8]. Moreover, CHT's cationic nature encourages the interaction of the available functional groups in its structure with different molecules, polysaccharides, and proteins, opening possibilities for designing transdermal drug-release systems, wound dressings, in vitro models, and other tissue-engineering applications [3,[9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach

et al. 2023

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Emulsion-based systems that combine natural polymers with vegetable oils have been identified as a promising research avenue for developing structures with potential for biomedical applications. Herein, chitosan (CHT), a natural polymer, and virgin coconut oil (VCO), a resource obtained from coconut kernels, were combined to create an emulsion system. Phytantriol-based cubosomes encapsulating sodium diclofenac, an anti-inflammatory drug, were further dispersed into CHT/VCO- based emulsion. Then, the emulsions were frozen and freeze-dried to produce scaffolds. The scaffolds had a porous structure ranging from 20.4 to 73.4 µm, a high swelling ability (up to 900%) in PBS, and adequate stiffness, notably in the presence of cubosomes. Moreover, a well-sustained release of the entrapped diclofenac in the cubosomes into the CHT/VCO-based system, with an accumulated release of 45 ± 2%, was confirmed in PBS, compared to free diclofenac dispersed (80 ± 4%) into CHT/VCO-based structures. Overall, the present approach opens up new avenues for designing porous biomaterials for drug delivery through a sustainable pathway.

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Section: Introductionmentioning

confidence: 99%

Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach

et al. 2023

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“…For all of these qualities, they are used, for example, as materials for transporting pharmaceutical molecules and substances (such as enzymes, antibiotics and antineoplastic drugs, etc. ), in ocular, dental, nasal and other systems [153,229,230]. Biopolymers from different sources and that have pharmaceutically active ingredients (capable of influencing the drug delivery process), are used for the production of Drug Delivery Systems (DDS), usually in the form of microcapsules, microspheres, nanospheres, hydrogels, nanogels and liposomes [153,229].…”

Section: Biopolymers In Pharmacology and Medicinementioning

confidence: 99%

An Overview on Wood Waste Valorization as Biopolymers and Biocomposites: Definition, Classification, Production, Properties and Applications

et al. 2022

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Bio-based polymers, obtained from natural biomass, are nowadays considered good candidates for the replacement of traditional fossil-derived plastics. The need for substituting traditional synthetic plastics is mainly driven by many concerns about their detrimental effects on the environment and human health. The most innovative way to produce bioplastics involves the use of raw materials derived from wastes. Raw materials are of vital importance for human and animal health and due to their economic and environmental benefits. Among these, wood waste is gaining popularity as an innovative raw material for biopolymer manufacturing. On the other hand, the use of wastes as a source to produce biopolymers and biocomposites is still under development and the processing methods are currently being studied in order to reach a high reproducibility and thus increase the yield of production. This study therefore aimed to cover the current developments in the classification, manufacturing, performances and fields of application of bio-based polymers, especially focusing on wood waste sources. The work was carried out using both a descriptive and an analytical methodology: first, a description of the state of art as it exists at present was reported, then the available information was analyzed to make a critical evaluation of the results. A second way to employ wood scraps involves their use as bio-reinforcements for composites; therefore, the increase in the mechanical response obtained by the addition of wood waste in different bio-based matrices was explored in this work. Results showed an increase in Young’s modulus up to 9 GPa for wood-reinforced PLA and up to 6 GPa for wood-reinforced PHA.

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“…Ideally, these scaffolds should accomplish some basic principles for tissue engineering by: (i) showing specific biological properties such as nontoxicity, biocompatibility, low antigenicity and biodegradability, (ii) integrating well with the surrounding tissues; (iii) coping with the biomechanical stress, such as in locomotion; (iv) supporting the total integrity of cells and their viability that include proliferation and differentiation; and (v) promoting the natural ingrowth of the native tissue; among others [ 3 , 12 ]. In fact, biocompatibility is a critical concern and new scaffolds should cause only a negligible immune response and avoid severe inflammation, which is associated with a decreased healing rate and, in some cases, rejection by the human body [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues

Carvalho

Lobo

Rodrigues

et al. 2023

Gels

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The self-repair capacity of human tissue is limited, motivating the arising of tissue engineering (TE) in building temporary scaffolds that envisage the regeneration of human tissues, including articular cartilage. However, despite the large number of preclinical data available, current therapies are not yet capable of fully restoring the entire healthy structure and function on this tissue when significantly damaged. For this reason, new biomaterial approaches are needed, and the present work proposes the development and characterization of innovative polymeric membranes formed by blending marine origin polymers, in a chemical free cross-linking approach, as biomaterials for tissue regeneration. The results confirmed the production of polyelectrolyte complexes molded as membranes, with structural stability resulting from natural intermolecular interactions between the marine biopolymers collagen, chitosan and fucoidan. Furthermore, the polymeric membranes presented adequate swelling ability without compromising cohesiveness (between 300 and 600%), appropriate surface properties, revealing mechanical properties similar to native articular cartilage. From the different formulations studied, the ones performing better were the ones produced with 3 % shark collagen, 3% chitosan and 10% fucoidan, as well as with 5% jellyfish collagen, 3% shark collagen, 3% chitosan and 10% fucoidan. Overall, the novel marine polymeric membranes demonstrated to have promising chemical, and physical properties for tissue engineering approaches, namely as thin biomaterial that can be applied over the damaged articular cartilage aiming its regeneration.

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Biopolymer membranes in tissue engineering

Cited by 4 publications

References 81 publications

Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach

Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach

An Overview on Wood Waste Valorization as Biopolymers and Biocomposites: Definition, Classification, Production, Properties and Applications

Advanced Polymeric Membranes as Biomaterials Based on Marine Sources Envisaging the Regeneration of Human Tissues

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