Biopolymer–clay nanocomposites for controlled drug delivery

Abstract

Polymer-clay nanocomposites have attracted great attention worldwide from both academic and industrial points of view. This review aims at reporting on very recent developments in types of polymer-clay nanocomposites, their constituents, synthetic routes, properties and their uses as carriers for drug delivery. This new family of composite materials frequently exhibits remarkable improvements of material properties when compared with the matrix polymers alone or conventional micro-and macrocomposites. Pharmaceutically, interesting improvements include increased mechanical and rheological properties, reduced drug permeability and water uptake and controlled release characteristics. On the basis of these properties, polymer-clay nanocomposites are extending their applicability to the design of new drug release dosage forms with highly specific technological and biopharmaceutical properties, such as swelling, film forming, bioadhesion, and cell uptake. Overall, there is an essential requirement directed towards a more comprehensive understanding of the supramolecular structure, drug loading and release mechanisms of these hybrid materials.

Antimicrobial Nanocomposites Prepared from Montmorillonite/Ag+/Quaternary Ammonium Nitrate

“…To improve the compatibility between the antimicrobial and polymer, surface modification of the antimicrobial is required. Furthermore, a lot of researches [20][21][22][23] shown that nanoparticles, such as clay and graphene nanoplatelets which was incorporated in antimicrobial polymer nanocomposites, allowed for the tuning of the release of antimicrobial agents, 2 Journal of Nanomaterials especially reducing the burst release effect, without hindering the antimicrobial activity of the obtained materials. The aim of this work was to prepare organic antiseptic MMT with good compatibility and dispersibility for use as a nanoadditive in polymers.…”

Structured Biodegradable Polymeric Microparticles for Drug Delivery Produced Using Flow Focusing Glass Microfluidic Devices

“…1 Limitations such as poor patient compliance (due to missing or altering dosages) and difficulty in attainment of steady state conditions (as a result of peakvalley plasma concentration fluctuations) have led to poor drug efficacy and toxicity as consequences of underdosing and overdosing of drugs respectively in patients. 2 Drug delivery systems have been designed to overcome these limitations and extend, delay and target drug release [3][4][5][6] .…”

“…7 Biocompatible polymeric materials such as non-biodegradable hydrophobic polymers, 8 hydrogels, 9 water soluble polymers, 10 and synthetic biodegradable polymers have been widely used as vehicles for drug delivery. 1 Biodegradable polymers have been mainly used in the form of microspheres, since they offer high surface area for adhesion and drug release and a low drag force during mobility in fluids. 11 The most common biodegradable synthetic polymers are poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) 12 , and polycaprolactone (PCL), 1,13 due to their approval by FDA (Food and Drug Administration) 14 and environmentally friendly nature.…”

“…1 Biodegradable polymers have been mainly used in the form of microspheres, since they offer high surface area for adhesion and drug release and a low drag force during mobility in fluids. 11 The most common biodegradable synthetic polymers are poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA) 12 , and polycaprolactone (PCL), 1,13 due to their approval by FDA (Food and Drug Administration) 14 and environmentally friendly nature. In order to meet different dosage requirements, there is a strong need to modify drug solubility and release rate by incorporation of different additives into a host biodegradable polymer.…”

Variability of the surface properties of sepiolite

“…Some examples are the adsorption of cationic-, anionic-and neutral surfactants ( b zdemir et al, 2007 ;del Hoyo et al, 2008) and the preparation of a wide variety of nanocomposites (G6mez-Aviles et al, 2010;Jia et al, 2010;Chen et al, 2011) as well as a variety of others. More recently, the use of sepio lite in health care products (Viseras et al, 2008) and in the geological storage of CO 2 (Galan et al, 2011) has been investigated. direction.…”