Biopolymer-based functional composites for medical applications

Park, Sung-Bin; Lih, Eugene; Park, Kwang-Sook; Joung, Yoon Ki; Han, Dong Keun

doi:10.1016/j.progpolymsci.2016.12.003

Cited by 316 publications

(137 citation statements)

References 331 publications

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“…A quite successful polymer for in vitro applications could turn out to be ineffective once used in vivo. Very few examples of commercially available biopolymers are used for in vivo applications, with most of them being based on hyaluronic acid or collagen polymers [179]. A way to get around the reduced biocompatibility of biopolyesters, for example, PLGA, is to create composites that incorporate extracellular matrix (ECM) elements.…”

Section: Bioplastics Polymers As Implants In Vivomentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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The success of oil-based plastics and the continued growth of production and utilisation can be attributed to their cost, durability, strength to weight ratio, and eight contributions to the ease of everyday life. However, their mainly single use, durability and recalcitrant nature have led to a substantial increase of plastics as a fraction of municipal solid waste. The need to substitute single use products that are not easy to collect has inspired a lot of research towards finding sustainable replacements for oil-based plastics. In addition, specific physicochemical, biological, and degradation properties of biodegradable polymers have made them attractive materials for biomedical applications. This review summarises the advances in drug delivery systems, specifically design of nanoparticles based on the biodegradable polymers. We also discuss the research performed in the area of biophotonics and challenges and opportunities brought by the design and application of biodegradable polymers in tissue engineering. We then discuss state-of-the-art research in the design and application of biodegradable polymers in packaging and emphasise the advances in smart packaging development. Finally, we provide an overview of the biodegradation of these polymers and composites in managed and unmanaged environments.

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Section: Bioplastics Polymers As Implants In Vivomentioning

confidence: 99%

Recent Advances in Bioplastics: Application and Biodegradation

et al. 2020

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“…c) Muscle stem cells delivered by the injectable scaffold showed more robust proliferation. [84] Additionally, these naturally derived materials also have the advantage of showing minimal inflammatory responses even after long-term implantation. [66] Copyright 2017, National Academy of Sciences.…”

Section: Engineering Precision Biomaterials For Tissue Engineering Anmentioning

confidence: 99%

Engineering Precision Medicine

et al. 2018

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Advances in genomic sequencing and bioinformatics have led to the prospect of precision medicine where therapeutics can be advised by the genetic background of individuals. For example, mapping cancer genomics has revealed numerous genes that affect the therapeutic outcome of a drug. Through materials and cell engineering, many opportunities exist for engineers to contribute to precision medicine, such as engineering biosensors for diagnosis and health status monitoring, developing smart formulations for the controlled release of drugs, programming immune cells for targeted cancer therapy, differentiating pluripotent stem cells into desired lineages, fabricating bioscaffolds that support cell growth, or constructing “organs‐on‐chips” that can screen the effects of drugs. Collective engineering efforts will help transform precision medicine into a more personalized and effective healthcare approach. As continuous progress is made in engineering techniques, more tools will be available to fully realize precision medicine's potential.

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“…Biopolymers are used clinically in scaffolds, bone, skin and other parts in human [15]. Biopolymer composites have sensors, motion transducers, electromagnetic shielding materials and microwave absorbers applications in electronic industry [16].…”

Section: Applications Of Phas and Related Biocompositesmentioning

confidence: 99%

Potential of polyhydroxyalkanoate (PHA) polymers family as substitutes of petroleum based polymers for packaging applications and solutions brought by their composites to form barrier materials

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et al. 2017

Pure and Applied Chemistry

107

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Today, there is an increasing concern about protection of ecological systems. Petro-based synthetic polymers are not biodegradable and cause environmental pollution. These polymers that are stuck in nature, affect wildlife adversely. Also, in future petrochemical materials will drain away and demand for ecofriendly plastics which can substitute synthetic plastics will increase. Biopolymers are products which can be degraded by enzymatic activities of various microorganisms, and the degradation products are nontoxic. They are attractive alternatives to non-degradable materials in short-term applications such as packaging. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a member of polyhydroxyalkanoate (PHA) family which is biodegradable and produced by microorganism. It has good gas barrier properties that make it convenient to use in different applications. The present paper gives an overview on PHAs and their composites, their main properties, with a specific focus on potential applications of PHBV in packaging.

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Biopolymer-based functional composites for medical applications

Cited by 316 publications

References 331 publications

Recent Advances in Bioplastics: Application and Biodegradation

Recent Advances in Bioplastics: Application and Biodegradation

Engineering Precision Medicine

Potential of polyhydroxyalkanoate (PHA) polymers family as substitutes of petroleum based polymers for packaging applications and solutions brought by their composites to form barrier materials

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