Bioplast� fibrin implants in nasoseptal perforation

Gyeney, L.; Kerényi, Géza

doi:10.1007/bf00469742

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Hungarian government. [68][69][70][71][72][73][74] The Hungarian IP was sold to Ethicon in the early mid 1970s, and the technology was shelved due to the advent of modern plastics as well as new concerns over the bovine-derived products. Cost was also an issue due to the high cost of isolating the large volumes of fibrinogen needed to make such plastics.…”

Section: Plasma-based Biomaterials For Tissue Repairmentioning

confidence: 99%

Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies

Smith

Weiss

Burgess

et al. 2013

Disruptive Science and Technology

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Platelets contain an array of growth factors, extracellular matrix molecules, and other signaling molecules that are released into the injury site upon platelet activation, thus providing the cues needed to help initiate and orchestrate tissue repair. In an effort to harness this activity for therapeutic use, autologous concentrated platelet-rich plasma (PRP) has become a popular therapy, particularly in sports medicine, where the desired outcome is to overcome the body's limitations to tissue repair and accelerate healing. However, the effectiveness of PRP therapies remains controversial due to variable clinical outcomes. Potential sources of variability include the different types of platelet concentrators as well as the inherent variation in patient-to-patient platelet and growth factor quality and quantity. Additionally, PRP, either activated pre-or postinjection, cannot be spatially contained in an injury site and is rapidly resorbed. A further limitation to PRP is that it is not a simple, off-the-shelf solution. We have developed solid, bioactive plasma-based biomaterials (PBMs) that may address these issues. Unlike platelet concentrators, which concentrate the platelets and subsequently discard a significant volume of plasma, we utilize the entire plasma (including the platelets), which contains vital growth factors and other components that are not platelet-derived. Pooled plasma is utilized to reduce PBM lot-to-lot variability. PBMs are inexpensive to manufacture, safe, available as off-the-shelf products, formable into complex 3D shapes, and biodegradable with tunable biomechanical and degradation properties. PBM retention of growth factor activity has been demonstrated with the use of cell proliferation assays. Biocompatibility has been established both in vitro and in vivo. Further, the initial feasibility of PBMs to stimulate the repair of a bone defect was demonstrated in a mouse calvarial defect model. Overall, PBMs represent a platform technology with significant potential to be a disruptive new therapy option in a variety of clinical applications, not only in major clinical markets, but also in third world and developing countries, where the need is high, but where the cost is a barrier to treatment.

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Section: Plasma-based Biomaterials For Tissue Repairmentioning

confidence: 99%

Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies

Smith

Weiss

Burgess

et al. 2013

Disruptive Science and Technology

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“…Suggestions concerning the use of artificial material or implants associated with closure techniques were given by Gyeney and Kerenyi 20 who in 1977 reported the closure of septal perforation through fibrin implants (Bioplast®). Kridel et al in 1998 21 suggested the use of a biosynthetic substitute (Acellular Human Dermal Allograft®), having reported success in the closure of eleven among 12 perforations treated.…”

Section: Literature Reviewmentioning

confidence: 99%

Fechamento de perfuração septal nasal em coelhos com celulose bacteriana

Neto¹,

Dolci²

2010

Braz. j. otorhinolaryngol. (Impr.)

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Alloplastic materials can be used together with tissue and structure to close nasal septal perforation. Aim to test cellulose use in the closure of septal perforation in rabbits and to compare fibrosis, inflammation, vascular congestion and graft integrity. Materials and Methods Fifteen rabbits. The rabbits were divided into two groups: Control: Five rabbits and Bionext® and fibrin glue Tissucol®: Ten rabbits. Septal perforations were done in all of them. In the Bionext® group the closure was performed with the placement of cellulose. Results Two rabbits died in the first week. Cellulose group: 2 closures without the cellulose in between the septum membrane and in 4 cases the graft stood in the middle of the perforation locked in place by the edges. No closure in the control group. Conclusion There was no closure of the perforation of the nasal septum with the graft between the septum membranes. There was no statistically significant difference concerning acute inflammation, vascular congestion and fibrosis between the 2 groups. In cases in which the graft remained in place, there was no change in its integrity. It may be used as a substructure for reepithelization of the perforation edges.

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Ultrastructural study concerning disintegration of fibrin foam used as filling material after partial hypophysectomy in rats

1980

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After partial hypophysectomy in rats, fibrin foam was implanted in the wound cavity. The fate of the implant was followed over a period of time up to three months by light and electron microscopy. First of all granulocytes appeared, whose granules obviously participated in the fragmentation of the fibrin network. Two days after operation and then in rapidly increasing numbers histiocytes could be found which surrounded the fibrin fibres with pseudopodia and absorbed them. They were broken down intracellularly by the lysosomes. In the wound cavity the gradually increasing number of fibroblasts formed collagen that often lay close to the fibrin fibres. The disintegration of the Fibrospum corresponded largely to that of natural native fibrin even though some could be identified three months after operation. The isolated appearance of foreign giant cells argued in favour of a moderate tuberculin type allergic reaction by the rat.

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Bioplast� fibrin implants in nasoseptal perforation

Cited by 4 publications

References 6 publications

Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies

Biologically Active Blood Plasma-Based Biomaterials as a New Paradigm for Tissue Repair Therapies

Fechamento de perfuração septal nasal em coelhos com celulose bacteriana

Ultrastructural study concerning disintegration of fibrin foam used as filling material after partial hypophysectomy in rats

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