Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review

Emon, Bashar; Bauer, Jessica; Jain, Yasna; Jung, Barbara; Saif, M. Taher A.

doi:10.1016/j.csbj.2018.07.003

Cited by 206 publications

(193 citation statements)

References 148 publications

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“…The higher range of the resonant frequencies and moduli seen in the cellular layers found in verrucous carcinoma, basal cell carcinoma, and actinic keratosis may be due to either changes in the attachments between cells or due to the stiffening of individual cells. Increased tissue stiffness has been shown to be a characteristic of cancerous tissues and potential tumor metastasis …”

Section: Discussionmentioning

confidence: 99%

“…Note the modulus for cellular materials (fat and Staph Aureus) is lower (<0.1 MPa) than for normal dermal collagen (2 to 3 MPa) and scar tissue (7 MPa). Calibration samples include decellularized human dermis at different values of the external strain, porcine fat, elastic tissue, and bovine cartilage [Colour figure can be viewed at wileyonlinelibrary.com]…”

Section: Methodsmentioning

confidence: 99%

“…Increased tissue stiffness (also termed modulus) has been shown to be a characteristic of potential tumor metastasis . Under normal conditions, the epidermis is thin and the mechanical properties cannot be measured.…”

Section: Introductionmentioning

confidence: 99%

“…Using VOCT to image and analyze the biomechanical properties of tissues non‐invasively and non‐destructively, it is possible to get a “virtual biopsy” of normal skin and abnormal skin lesions . Correlating these measurements with in vitro calibration data can be used to interpret mechanical measurements made in vivo . The purpose of this paper is to compare a virtual biopsy of normal skin and a melanocytic nevus to the physical properties of several different skin lesions in an attempt to define virtual biopsy parameters that may be useful to differentiate malignant from benign lesions.…”

Section: Introductionmentioning

confidence: 99%

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Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

Silver

Shah

Richard³

et al. 2019

Skin Research and Technology

132

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Background Increased tissue stiffness (also termed modulus) has been shown to be a characteristic of potential tumor metastasis. Measured values of the stiffness of tumors and cancer cells are reported in the literature to increase compared to neighboring normal tissues. Yet the relationship between the mechanical properties of cells and the extracellular matrix has yet to be correlated with the histopathology of cancerous lesions. Materials and Methods We have developed a technique to do virtual biopsies of skin lesions by combining images made using optical coherence tomography with stiffness measurements made simultaneously using vibrational analysis. The technique is termed vibrational optical coherence tomography (VOCT). Results In this paper, we report that precancerous and cancerous lesions are characterized by changes in both the morphology and stiffness of the cellular components of the skin. The ratio of the peak heights that correspond to the epidermal (40‐60Hz) and dermal (140‐160 Hz) resonant frequencies appear to be different for benign and cancerous or precancerous lesions compared with normal skin and scar. Conclusions Cell‐to‐cell and epidermal‐to‐dermal interactions may be very important in evaluating the potential of skin lesions to become malignant. These interactions can be evaluated using VOCT, a new technique for performing “virtual biopsies” of skin lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

Silver

Shah

Richard³

et al. 2019

Skin Research and Technology

132

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“…1,2 However, there are some studies that have analysed the relationship between cell density and cell phenotypes that suggest cell density is an important aspect in tumour development. Additionally, tumour growth and progress will also make the microenvironment more complex.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of the effects of cell culture density on the metastasis of breast cancer cells

Guo

Mixin

Lan

et al. 2019

Cell Biochemistry & Function

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Cancer cell progression and proliferation increase cell density, resulting in changes to the tumour site, including the microenvironment. What is not known is if increased cell density influences the aggressiveness of cancer cells, especially their proliferation, migration, and invasion capabilities. In this study, we found that dense cell culture enhances the aggressiveness of the metastatic cancer cell lines, 4T1 and ZR-75-30, by increasing their proliferation, migration, and invasion capabilities. However, a less metastatic cell line, MCF-7, did not show an increase in aggressiveness, following dense cell culture conditions. We conducted a differential proteomic analysis on 4T1 cells cultured under dense or sparse conditions and identified an increase in expression for proteins involved in migration, including focal adhesion, cytoskeletal reorganization, and transendothelial migration. In contrast, 4T1 cells grown under sparse conditions had higher expression levels for proteins involved in metabolism, including lipid and phospholipid binding, lipid and cholesterol transporter activity, and protein binding.These results suggest that the high-density tumour microenvironment can cause a change in cellular behaviour, leading towards more aggressive cancers.Significance of the study: Metastasis of cancer cells is an obstacle to the clinical treatment of cancer. We found that dense cultures made metastatic cancer cells more potent in terms of proliferation, migration, and invasion. The proteomic and bioinformatic analyses provided some valuable clues for further intensive studies about the effects of cell density on cancer cell aggressiveness, which were associated with events such as pre-mRNA splicing and RNA transport, focal adhesion and cytoskeleton reorganization, ribosome biogenesis, and transendothelial migration, or associated with proteins, such as JAM-1 and S100A11. This investigation gives us new perspectives to investigate the metastasis mechanisms related to the microenvironment of tumour sites.

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Metallodrugs: an approach against invasion and metastasis in cancer treatment

2022

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Cancer is a heterogeneous and multifactorial disease that causes high mortality throughout the world; therefore, finding the most effective therapies is a major research challenge. Currently, most anticancer drugs present a limited number of well‐established targets, such as cell proliferation or death; however, it is important to consider that the worse progression of cancer toward pathological stages implies invasion and metastasis processes. Medicinal Inorganic Chemistry (MIC) is a young area that deals with the design, synthesis, characterization, preclinical evaluation, and mechanism of action of new inorganic compounds, called metallodrugs. The properties of metallic ions allow enriching of strategies for the design of new drugs, enabling the adjustment of physicochemical and stereochemical properties. Metallodrugs can adopt geometries, such as tetrahedral, octahedral, square planar, and square planar pyramid, which adjusts their arrangement and facilitates binding with a wide variety of targets. The redox properties of some metal ions can be modulated by the presence of the bound ligands to adjust their interaction, thereby opening a range of mechanisms of action. In this regard, the mechanisms of action that trigger the biological activity of metallodrugs have been generally identified by: (a) coordination of the metal to biomolecules (for instance, cisplatin binds to the N7 in DNA guanine, as Pt‐N via coordination of the inhibition of enzymes); (b) redox‐active; and (c) ROS production. For this reason, a series of metallodrugs can interact with several specific targets in the anti‐invasive processes of cancer and can prevent metastasis. The structural base of several metal compounds shows great anticancer potential by inhibiting the signaling pathways related to cancer progression. In this minireview, we present the advances in the field of antimetastatic effects of metallodrugs.

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Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini Review

Cited by 206 publications

References 148 publications

Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

Comparative “virtual biopsies” of normal skin and skin lesions using vibrational optical coherence tomography

Proteomic analysis of the effects of cell culture density on the metastasis of breast cancer cells

Metallodrugs: an approach against invasion and metastasis in cancer treatment

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