Biophysics in Membrane of Cells

Abstract

The membrane of a cell, often compared to a dynamic city border, carries out an intricate dance of controlling entry and exit, guarding the valuable life processes occurring inside [...]

Hydantoin derivative dimers as broad-spectrum antimicrobial agents against ESKAPE pathogens with enhanced killing rate and stability

“…Gram-positive bacteria have a thicker peptidoglycan layer but lack an outer membrane, which makes them more susceptible to antimicrobial agents. 34,35 Therefore, we carried out studies for inner membrane (IM) and outer membrane permeabilization separately to further investigate the effect of compound 18 on bacteria cell membrane integrity. The IM permeabilization of S. aureus and E. coli was determined using propidium iodide (PI) uptake assays.…”