Biophysics and Thermodynamics: The Scientific Building Blocks of Bio-inspired Drug Delivery Nano Systems

Demetzos, Costas

doi:10.1208/s12249-015-0321-1

Cited by 29 publications

(7 citation statements)

References 18 publications

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“…19,20 Its mode of action is explained by biophysics and thermodynamics approaches, that is, the degree of hydration, as based on the degree of hydration to provide protein protection and stable mechanical support. 29-31 Importantly, while hydrationis necessary for wound healing, degree of protein hydration is associated with their function and chemical stability. 29-31 Indeed, excess protein hydration, which is related to times and duration of their exposure to water (twice per week), impairs their integrity and functionality.…”

Section: Discussionmentioning

confidence: 99%

“…29-31 Importantly, while hydrationis necessary for wound healing, degree of protein hydration is associated with their function and chemical stability. 29-31 Indeed, excess protein hydration, which is related to times and duration of their exposure to water (twice per week), impairs their integrity and functionality. 20-22,29-31…”

Section: Discussionmentioning

confidence: 99%

“…29-31 Indeed, excess protein hydration, which is related to times and duration of their exposure to water (twice per week), impairs their integrity and functionality. 20-22,29-31…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes

Παπάνας

Demetzos

Pippa

et al. 2016

The International Journal of Lower Extremity Wounds

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A novel heparan sulfate glycosaminoglycan mimetic product for local application to promote wound healing (CACIPLIQ) has recently become available. It is a biophysical therapeutic product comprising a polysaccharide as an innovative biomaterial to accomplish mechanical tissue engineering and skin regeneration in the site of ulceration. We present a series of 12 patients with type 2 diabetes (4 men and 8 women; age 53-87 years; diabetes duration 8-25 years) having chronic resistance to therapy for foot and lower extremity ulcerations. CACIPLIQ was locally applied twice per week after careful debridement. Complete ulcer healing was accomplished in all patients after a mean treatment duration of 4.92 months (range = 2-12 months). The product was very well tolerated. In conclusion, these results, although preliminary, are encouraging and suggest adequate efficacy and safety of the new product in difficult-to-heal foot and lower extremity ulcerations in type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes

Παπάνας

Demetzos

Pippa

et al. 2016

The International Journal of Lower Extremity Wounds

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“…It has been shown that the antimicrobial activity of nanoencapsulated EO is enhanced due to its increase in solubility in aqueous phase. Moreover, it acts as a reservoir for bioactive compound which is released gradually over a prolonged time period [13].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and Antibiofilm Activities of Trans-Cinnamaldehyde Nanoemulsion Against Escherichia Coli

Raj

Gautam

Dang³

et al. 2019

Asian J Pharm Clin Res

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Objective: Trans-cinnamaldehyde (TC) has shown antimicrobial activity against various microorganisms, but its direct use has some disadvantages such as skin irritation, low bioavailability, and low solubility. The objective of the present work was to develop the oil-in-water nanoemulsions (NEs) of TC to enhance its antimicrobial activity against Escherichia coli. Methods: The NEs of TC were prepared using triton x-100 and isopropyl alcohol as surfactant and cosurfactant. The developed NE was studied for size, zeta potential, and stability. NEs were evaluated for antimicrobial and antibiofilm activity against E. coli as indicator organism. NEs possible mode of action on E. coli was assessed by scanning electron microscopy (SEM). Results: Stable NEs of TC exhibited a particle size of 210 nm and were able to inhibit the growth of planktonic as well as biofilm cultures of E. coli at 67 μg/ml. The ruthenium red staining indicated the inhibition of glycoprotein layer formation in extracellular matrix after treating with NE. TC-NE exhibited substantial decrease in E. coli growth as well as its viability at its minimum inhibitory concentration as determined by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The mode of action of cinnamaldehyde through β-galactosidase assay on E. coli ML-35p strain indicated that it altered the bacterial cell membrane permeability. SEM results showed the presence of holes on the cell wall of the E. coli in the presence of TC-NE. Conclusions: TC-NEs exhibited enhanced antimicrobial activity and were effective against E. coli biofilm. They also exhibited microbicidal activity and altered E. coli membrane permeability.

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“…Current liposomology is a huge and still progressing area. Liposomes belong to colloidal dispersion systems and are characterized as lyotropic liquid crystals (Demetzos 2008;2015). These particular liposomal lyotropic states are responsible for the mesophases taking place in phase transitions and are related to their thermal stress during phase transitions (Demetzos 2008;2015;Pippa et al, 2015).Liposomes are clinically used delivery systems with many advantages such as biocompatibility and biodegradability (Allen and Cullis, 2013).…”

Section: Introductionmentioning

confidence: 99%

Design and development of multi-walled carbon nanotube-liposome drug delivery platforms

Pippa

Chronopoulos

Stellas

et al. 2017

International Journal of Pharmaceutics

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The aim of this study is to design and develop delivery platforms made of liposomes and multi-walled carbon nanotubes (MWCNTs). We used different lipids with different main transition temperature (Tm) and differently functionalized MWCNTs with organic addends possessing either positive or negative charge. The phospholipids used for the formulations were 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) (Tm=41°C) and L-α-phosphatidylcholine, hydrogenated Soy (HSPC) (Tm=53°C). By Differential Scanning Calorimetry (DSC), we studied the interaction between the DPPC and HSPC bilayers and MWCNTs. Liposome-MWCNTs delivery platforms prepared according to the protocol used in the literature. We used dynamic and electrophoretic light scattering in order to investigate the physicochemical characteristics of these mixed nanocarriers. The presence of MWCNTs causes alterations of the size of the conventional HSPC and DPPC liposomes. The ζ-potential values of mixed nanocarriers are near zero. This observation indicates the effective incorporation of MWCNTs into the lipid bilayer of liposomes. Fluorescence spectroscopy has been utilized to exact some qualitative information on the internal nanostructure and nanoenvironment of the lipid/carbon nanotube mixed structures. Finally, we conclude that we successfully prepare and completely characterize mixed nanocarriers composed of lipids and MWCNTs, with low toxicity as indicated by in vitro screening.

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Biophysics and Thermodynamics: The Scientific Building Blocks of Bio-inspired Drug Delivery Nano Systems

Cited by 29 publications

References 18 publications

Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes

Efficacy of a New Heparan Sulfate Mimetic Dressing in the Healing of Foot and Lower Extremity Ulcerations in Type 2 Diabetes

Antibacterial and Antibiofilm Activities of Trans-Cinnamaldehyde Nanoemulsion Against Escherichia Coli

Design and development of multi-walled carbon nanotube-liposome drug delivery platforms

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