Biophysical Models for the Role of Intracellular Repair in the Anomalous Enhancement of Neoplastic Transformation by Low Doses of Fission-spectrum Neutrons at Low Dose Rates: Reply to the Letter to the Editor by P. R. Burch and M. S. Chesters

Elkind, M. M.; Hill, Colin K.

doi:10.1080/09553008614550551

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Thus, the model of Burch and Chesters is distinctly different from that of Rossi and Kellerer because intracellular modification of pretransformational lesions is involved. In our reply (Elkind and Hill 1986) to the letter by Burch and Chesters, we indicated that we agreed with the conceptual framework of their model. We had also referred to intracellular processes in our reply to Barendensen's letter, ideas which had been discussed earlier (e.g.…”

Section: Dose Cgymentioning

confidence: 65%

Age-dependent Variations in Cellular Susceptibility to Neoplastic Transformation: Reply to Letter to the Editor by H. H. Rossi and A. M. Kellerer

Elkind

Hill

1986

International Journal of Radiation Biology and Related Studies

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Section: Dose Cgymentioning

confidence: 65%

Age-dependent Variations in Cellular Susceptibility to Neoplastic Transformation: Reply to Letter to the Editor by H. H. Rossi and A. M. Kellerer

Elkind

Hill

1986

International Journal of Radiation Biology and Related Studies

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“…Several models incorporating alternative mechanisms for the production and repair of radiation damage have been proposed to account for the increase In transformation (Rossi and Kellerer 1986;Burch and Chesters 1986;Elkind and Hill 1986), but it is extremely difficult to test these models with conventional broad-beam irradiation since the majority of the cells exposed receive no damage or are damaged by a single particle track and cannot be involved in the dose-rate effect. We will overcome this problem by using a charged particle microbeam system to irradiate individual cells with a specified number of charged particle tracks at precisely controlled positions.…”

Section: Alpha-particle Mlcrobeam Irradiation L a Braby And W D Reecementioning

confidence: 99%

Pacific Northwest Laboratory annual report for 1988 to the DOE Office of Energy Research: Part 4, Physical sciences

Touburen¹

1989

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Chernobyl Database Management The Chemobyl Database project Is developing and maintaining an Information system to provide researchers with data relating to the Chernobyl nuclear accident of April 1986. The system is the official United States repository for Chemobyl data, and includes a bibliography and diverse quantitative measurements with supporting Information. Use of Information contained In this system presents an opportunity for researchers to evaluate predictions of historical risk, transport, and deposition models previously based on laboratory experiments, computer simulations, and limited measurement data. Project staff have used structured systems analysis techniques to analyze, design, and document the system. Measurement data have been obtained and will be solicited In the future from domestic and foreign organizations. A committee of database advisors, representing a spectrum of potential users, reviews data to determine research usefulness and to develop approaches for standardizing data in the system. Researchers can retrieve data via on-line menus and forms or by requesting information from project staff. The analysis, design, and user interface is Implemented. In subsequent years, project staff will continue to obtain and load data, enhance quality and standardization of data, publicize the system, and support researcher requests.

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“…A number of explanations have already been published (Barendsen 1985, Burch and Chesters 1986, Rossi and Kellerer 1986, Elkind and Hill 1986a,b, Ward et al . 1987, Sykes and Watts 1989, Brenner and Hall 1990), but to the extent that these have received little subsequent attention and new explanations continue to appear, one must conclude that the older explanations are considered to be inadequate .…”

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confidence: 99%

‘Inter Silvas Academi Quaerere Verum’: Reply to Letter to the Editor by M. M. Elkind.

Balcer‐Kubiczek

Harrison

1991

International Journal of Radiation Biology

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The reconciliation of apparently contradictory data on the inverse dose-rate effect for fission neutron-induced neoplastic transformation in vitro has proven to be a daunting task . A number of explanations have already been published (Barendsen 1985, Burch and Chesters 1986, Rossi and Kellerer 1986, Elkind and Hill 1986a,b, Ward et al . 1987, Sykes and Watts 1989, Brenner and Hall 1990, but to the extent that these have received little subsequent attention and new explanations continue to appear, one must conclude that the older explanations are considered to be inadequate . With an ever-increasing data base available for analysis, Elkind (1991) has developed a new explanation which attempts to encompass numerous features of the available data in a comprehensive, detailed manner . However, the points enumerated below demonstrate that a similar volume of evidence arguing against this latest explanation has been omitted from the analysis, so that the conclusions are not supportable .1 . The letter of Elkind (1991) focused on possible discrepancies of the experiments showing no inverse dose-rate effect, but within the framework of the proposed model fails to consider the major quantitative discrepancy of quoted experiments showing positive results . Specifically, the first reported enhancement of transformation in C3H/l0T} cells had a maximal value of about 20 at 0 . 1 Gy fission neutron dose (Hill et al . 1982), whereas in subsequent work, where the inverse dose-rate effect was observed for fission-spectrum or other energy neutrons in a similar neutron dose range, enhancement was estimated to be around 2 or less than 2 (Miller et al . 1988, Jones et al . 1989, Hill 1989) . These newer results also failed to reproduce the biphasic dose-response curves in the initial reports by Hill et al . (1982Hill et al . ( , 1984aHill et al . ( , 1985 . Further, it is not certain that some of these small enhancements could be proven statistically significant, mostly because this series covered a narrow range of doses (Miller et al . 1988, BalcerKubiczek and Harrison 1989, Jones et al . 1989) .2 . A substantial body of data indicating no inverse dose-rate effect for neutrons was not included in the proposed explanation . To date we have accumulated a solid data base for fission neutrons indicating no dose-rate effect for survival, neoplastic trnsformation and mutation induction down to 0 . 05 Gy Harrison 1991) . Using an in vivo-in vitro mammary cell system, Ullrich (1986) found that low-dose-rate neutron exposures enhance progression to malignancy but not the number of cells initiated by neutrons . TerzaghiHowe (1989) found no difference in transformation frequency of epithelial cells between high-and low-dose-rate neutrons . Similarly, Saran et al. (1990Saran et al. ( , 1991 observed no effect of dose fractionation in C3H/10T cells following irradiation with fission neutrons, 1-MeV monoenergetic neutrons or 6-MeV monoenergetic neutrons . al. 1988, 1989), but omitted our results with density-inhibited cultures reported in the...

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Biophysical Models for the Role of Intracellular Repair in the Anomalous Enhancement of Neoplastic Transformation by Low Doses of Fission-spectrum Neutrons at Low Dose Rates: Reply to the Letter to the Editor by P. R. Burch and M. S. Chesters

Cited by 7 publications

References 7 publications

Age-dependent Variations in Cellular Susceptibility to Neoplastic Transformation: Reply to Letter to the Editor by H. H. Rossi and A. M. Kellerer

Age-dependent Variations in Cellular Susceptibility to Neoplastic Transformation: Reply to Letter to the Editor by H. H. Rossi and A. M. Kellerer

Pacific Northwest Laboratory annual report for 1988 to the DOE Office of Energy Research: Part 4, Physical sciences

‘Inter Silvas Academi Quaerere Verum’: Reply to Letter to the Editor by M. M. Elkind.

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