Biophysical Insights into Cancer Transformation and Treatment

Abstract

Biological systems are hierarchically self-organized complex structures characterized by nonlinear interactions. Biochemical energy is transformed into work of physical forces required for various biological functions. We postulate that energy transduction depends on endogenous electrodynamic fields generated by microtubules. Microtubules and mitochondria colocalize in cells with microtubules providing tracks for mitochondrial movement. Besides energy transformation, mitochondria form a spatially distributed proton charge layer and a resultant strong static electric field, which causes water ordering in the surrounding cytosol. These effects create conditions for generation of coherent electrodynamic field. The metabolic energy transduction pathways are strongly affected in cancers. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the generated electromagnetic field, respectively, and shifted and rebuilt frequency spectra. Disturbed electrodynamic interaction forces between cancer and healthy cells may favor local invasion and metastasis. A therapeutic strategy of targeting dysfunctional mitochondria for restoration of their physiological functions makes it possible to switch on the natural apoptotic pathway blocked in cancer transformed cells. Experience with dichloroacetate in cancer treatment and reestablishment of the healthy state may help in the development of novel effective drugs aimed at the mitochondrial function.

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

“…Experimental support for Frölich's ideas continues to accumulate. In 2013, Pokorný et al reviewed the current biophysical literature pertaining to cancer transformation [120], wherein measurements performed on living cells have disclosed electric and electromagnetic oscillations, including dielectrophoretic forces of the cellular oscillating electric field. The resulting attraction of dielectric particles depends on their permittivity [121].…”

“…The resulting attraction of dielectric particles depends on their permittivity [121]. We refer the reader to [120] for descriptions of the experimental and theoretical research of the cellular electromagnetic activity, which today, points strongly to microtubules as major sources of electromagnetic interactions. Evidence for a key role of EIWS-induced cytoskeleton disruption in cancer causation is discussed in Section 6.1 below.…”

Postulates on electromagnetic activity in biological systems and cancer

“…A model theoretical analysis based on a physical electromagnetic mechanism can explain interactions between cells in the tissue. 31,36,60 The interaction depends on the frequency spectrum, the space pattern, and the power of the electromagnetic field generated by the interacting entities (the cells). The cancer cell escapes from interactions with the surrounding healthy cells and performs individual activity if its frequency spectrum is rebuilt and shifted 39 and/or the space pattern disturbed.…”

Energy parasites trigger oncogene mutation

“…The vibrations can generate EMG field as the majority of biological macromolecules and structures are electrically polar, in particular microtubules (Pokorn y et al 1997, Pokorn y and Wu 1998, Jel ınek et al 2009. Mechanisms related to excitation of coherent EMG field in living system was described by Pokorn y et al (2011Pokorn y et al ( , 2013aPokorn y et al ( , 2013bPokorn y et al ( , 2014Pokorn y et al ( , 2015. Further experimental support was provided by Sahu et al (2013Sahu et al ( , 2014 by measuring microtubule oscillations and absorption in a broad frequency range (0.1-0.3 MHz, 10-30 MHz, 100-200 MHz, 1-20 GHz, infrared band at about 20 THz, and UV band at about 276-334 nm).…”