Abstract:The structural dynamics of two nucleosomes, one was H3 containing and other was CENP-A containing nucleosome, were characterized with molecular dynamics simulations and the findings were experimentally confirmed. The simulations showed that histone proteins of both, which is the core structure of nucleosome, are structurally stable and maintain the structure determined by x-ray crystallography, while the wrapped DNAs are highly flexible at the entry or exit region and largely deviate from the crystal structure… Show more
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