Biophysical characteristics of skin in diabetes: a controlled study

Hassan, Sk. Sarif; Farsinejad, Khalil; Firooz, Alireza; Davoudi, Seyyed Masoud; Robati, Reza M.; Hoseini, Mahya; Ehsani, Amirhooshang; Sadr, Bardia

doi:10.1111/j.1468-3083.2008.02950.x

Cited by 77 publications

(98 citation statements)

References 24 publications

(52 reference statements)

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“…The deposition amount of DSP was more than two much larger in DM group compared to that in the control, which may be related to the abnormal proliferation and differentiation of keratinocytes in the epidermis (Seirafi et al, 2008) and the altered hydration state of patients with diabetes. The increased proliferation of keratinocytes may accumulate the drug detained in corneum, preventing it to be absorbed further.…”

Section: Discussionmentioning

confidence: 99%

“…Sakai et al reported that the SC hydration and the activity of sebaceous glands decreased obviously in diabetics (Sakai et al, 2005). There were also studies that indicated hyperglycemia and decreased insulin signal were involved in the impairment of skin function (Sakai et al, 2003;Seirafi et al, 2008). In the presence of high glucose (20 mmol/l), the keratinocytes was larger, flattened and had lost some of their orientation toward each other, and the keratinocytes proliferation was decreased.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the exposure of keratinocytes to high glucose conditions could lead to an inhibition of the proliferation and autophosphorylation of insulin-like growth factor. Therefore, the skin cells proliferation-differentiation balance could be altered by high glucose (Spravchikov et al, 2001), which might affect the functions of the SC (Seirafi et al, 2008). Besides, microcirculation and dysmetabolism are also involved in the diabetic skin damage.…”

Section: Introductionmentioning

confidence: 99%

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The percutaneous permeability and absorption of dexamethasone esters in diabetic rats: a preliminary study

Song

Xiong

et al. 2013

Drug Delivery

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To evaluate the influence of diabetes on the permeation of dexamethasone acetate (DA) and dexamethansone sodium phosphate (DSP), the two major dexamethansone esters in clinical practice, when applied percutaneously, histochemical staining was used to determine the skin morphology; improved Franz diffusion cells and microdialysis were used to assess the percutaneous permeation of DA and DSP in normal and diabetic rats. Histopathological examination showed that the epidermal tissue of diabetic rat was much thinner, the epidermal cell layer was less clear and the stratified arrangement of epidemic cell had almost disappeared and progressive atrophy were developed on the subcutaneous fat. In vitro studies showed that the cumulative and the penetrated DSP amount in Group DM were higher. The mean flux value and the mean depositional amount of Group DM were increased significantly compared to those of Group CTL, whereas the amount of DA penetrating was of no difference. Microdialysis indicated that there was no significant difference between Group CTL and Group DM for all the pharmacokinetic parameters of DA. In contrast, the subcutaneous AUC all values and the C max of DSP were significantly increased compared to the control. In conclusion, diabetic rat skin significantly increased the percutaneous permeation of DSP but had no effect on that of DA. It suggests that patients with diabetes should consider the dose of administration when using DA, DSP or other glucocorticoids topically, as different liposolubilities may play some role in the permeability of these compounds via diabetic skin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The percutaneous permeability and absorption of dexamethasone esters in diabetic rats: a preliminary study

Song

Xiong

et al. 2013

Drug Delivery

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“…Nie zostało dotychczas jednoznacznie wykazane, czy wartość TEWL zmienia się w przebiegu cukrzycy [27,28]. Podejrzewa się, że zmniejszenie nawilżenia skóry, a w rezultacie jej suchość, mogą być wywoła-ne przez hiperglikemię lub hiperosmolarność osocza, a nie utratę wody z naskórka w wyniku parowania [27,28].…”

Section: Zmiany Biofizycznych Parametrów Skóry W Cukrzycyunclassified

Molecular factors involved in skin dryness in diabetic patients

Bednarski¹,

Lesiak²

2016

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STRESZCZENIECukrzyca, która jest chorobą przewlekłą oraz układową, dotyka aż 8,3% populacji ogólnej i staje się poważnym problemem klinicznym i finansowym dla systemów opieki zdrowotnej na świecie. Powikłania cukrzycy obejmują zarówno uszkodzenia wielu narządów wewnętrz-nych, jak i zmiany skórne, które mogą wyprzedzać kliniczne objawy cukrzycy. Ponadto skóra diabetyków często jest podrażniona i przesuszona, co przyczynia się do zwiększonego ryzyka występowania infekcji skórnych. Niemniej niewiele dotychczas wiadomo na temat molekularnych podstaw zmian zachodzących w skórze w przebiegu cukrzycy. Wszystkie prowadzone do tej pory badania koncentrują się wokół uszkodzenia bariery naskórkowej, zaburzeń integralności naskórka oraz zaburzeń funkcjonowania gruczołów łojowych. Innym, złożonym problemem jest sama pielęgnacja skóry osób chorujących na cukrzycę. Kompleksowe zrozumienie procesów zachodzących na poziomie komórkowym mogłoby pozwolić na odkrycie nowych markerów monitorujących skuteczność stosowanego leczenia zmian skórnych oraz nowych preparatów pielęgnacyjnych. ABSTRACTDiabetes is a chronic systemic disease affecting 8.3% of the general population, thus constituting an important clinical and financial problem for healthcare systems throughout the world. Complications of diabetes damage both many internal organs and skin. Skin complications of diabetes can anticipate its clinical symptoms. Diabetic skin, irritated and dry in many cases, is susceptible to skin infections. However, there is little known about molecular changes in skin in diabetes. Many studies are concentrated on epidermal barrier damage, dysfunction of epidermis integrity and dysfunction of sebaceous glands. Another complex problem is skin care in diabetic patients. A profound understanding of cellular-level processes in diabetes could lead to the discovery of new therapy efficacy markers and new skin care products. SŁOWA KLUCZOWE:cukrzyca, sucha skóra, emolienty.

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“…However, the stiffness of tissues such as arteries and skin is known to increase with age (9,10) and is especially high in patients with diabetes compared to healthy subjects (9,11). Pentosidine, one of the crosslinking AGEs, has a structure in which the lysine and arginine residues of tissue protein are cross-linked by a pentose such as ribose (12).…”

mentioning

confidence: 99%

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

Yui

Fujiwara

Harada

et al. 2017

J Nutr Sci Vitaminol

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Summary Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine. Rosmarinic acid (RA), a typical polyphenol in Lamiaceae plants, was identified as a major active component in LB extract (LBE). Furthermore, LBE or RA dose-dependently suppressed glycation-associated reactions such as increased fluorescence, yellowing of collagen fiber sheets, and degeneration of the fibrous structure of elastin fiber sheets. An open-label, parallel-group comparative trial was conducted in 28 healthy Japanese subjects aged 31-65 y who consumed LB tea (LB group) or barley tea (Control group) for 6 wk. The LB group showed significant reductions in brachial-ankle pulse wave velocity, reflecting arterial stiffness, and b* (yellow) color values in forearm skin compared with the Control group. A gender-stratified analysis revealed that cheek skin elasticity was significantly improved in the LB group compared with the Control group only in female subjects. It is concluded that the hot water extract of LB leaf has the potential to provide health benefits with regard to glycation-associated tissue damage in blood vessels and skin of healthy adults. Key Words lemon balm, glycation, pentosidine, arterial stiffness, skin elasticity Glycation, the non-enzymatic glycosylation of proteins, is known to be involved in the onset of various diseases and conditions of aging. The substances generated by this reaction are known as advanced glycation endproducts (AGEs). Since the tissue contents of AGEs in diabetic patients (1, 2) and diabetic animals (3) are known to be much higher than in their healthy counterparts, AGEs are considered to be involved in the progression of complications of diabetes such as diabetic nephropathy (4) and cataracts (5). Involvement of the accumulation of AGEs in cardiovascular diseases (6, 7) and Alzheimer's disease (8) has also been reported.However, the stiffness of tissues such as arteries and skin is known to increase with age (9, 10) and is especially high in patients with diabetes compared to healthy subjects (9, 11). Pentosidine, one of the crosslinking AGEs, has a structure in which the lysine and arginine residues of tissue protein are cross-linked by a pentose such as ribose (12). It has been reported that pentosidine content increases with age (2, 9, 12) and positively correlates with the degree of tissue stiffness (7,13,14). One of the causes of the deterioration of tissue elasticity in elderly or diabetic patients is considered to be the accumulation of crosslinking AGEs su...

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Biophysical characteristics of skin in diabetes: a controlled study

Cited by 77 publications

References 24 publications

The percutaneous permeability and absorption of dexamethasone esters in diabetic rats: a preliminary study

The percutaneous permeability and absorption of dexamethasone esters in diabetic rats: a preliminary study

Molecular factors involved in skin dryness in diabetic patients

Beneficial Effects of Lemon Balm Leaf Extract on In Vitro Glycation of Proteins, Arterial Stiffness, and Skin Elasticity in Healthy Adults

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