Biophysical Characteristics of Hyaluronic Acid Soft-Tissue Fillers and Their Relevance to Aesthetic Applications

Sundaram, Hema; Cassuto, Daniel

doi:10.1097/prs.0b013e31829d1d40

Cited by 155 publications

(152 citation statements)

References 19 publications

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“…1 Hyaluronic acid (HA) fillers are some of the most popular dermal filler agents, 2,3 which when injected into and below the dermis can provide cosmetic volume improvements. 2,4,5 However, these volume effects will diminish soon after injection. 6,7 Filler migration and (non)-enzymatic HA degradation can further lead to progressive volume loss and shape deformity at the site of injection requiring reinjection.…”

mentioning

confidence: 99%

“…HA filler is further characterized by HA concentration and degree of HA cross-linking. 4,5,9,12 Filler migration has been only partially addressed by increasing the viscosity of the injected solution. It is of great interest for plastic surgeons to be provided with an injectable filler compound that can predictably fill volume defects and will remain at the injection site for long-lasting results.…”

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confidence: 99%

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Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction

Cheng

Shih

et al. 2017

Tissue Engineering Part A

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Introduction: Hyaluronic acid (HA)-based fillers are used for various cosmetic procedures. However, due to filler migration and degradation, reinjections of the fillers are often required. Methacrylated HA (MA-HA) can be made into injectable shape-memorizing fillers (three-dimensional [3D] MA-HA) aimed to address these issues. In this study, shape retention, firmness, and biocompatibility of 3D MA-HA injected subcutaneously in mice were evaluated. Materials and Methods: Fifteen mice, each receiving two subcutaneous injections in their back, were divided into four groups receiving HA, MA-HA, 3D MA-HA, or saline, respectively. Digital imaging, scanning electron microscope (SEM) and in vivo imaging system (IVIS), durometry, and histology were utilized to evaluate in vitro/ vivo degradation and migration, material firmness, and the angiogenic (CD31) and immunogenic (CD45) response of the host tissue toward the injected materials. Results: Digital imaging, SEM, and IVIS revealed that 3D MA-HA fillers maintained their predetermined shape for at least 30 days in vitro and in vivo. Little volume effects were noted in the saline and other control groups. There were no differences in skin firmness between the groups or over time. Histology showed intact skin architecture in all groups. Three-dimensional MA-HA maintained its macroporous structure with significant angiogenesis at the 3D MA-HA/skin interfaces and throughout the 3D MA-HA. There was no significant inflammatory response to any of the injected materials. Conclusion: 3D MA-HA showed remarkable tissue compatibility, compliance, and shape predictability, as well as retention, and thus might be suitable for various skin sculpting and soft tissue reconstruction purposes.

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mentioning

confidence: 99%

Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction

Cheng

Shih

et al. 2017

Tissue Engineering Part A

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“…Also, it has low viscosity, which allows it to be injected easily and spread into surrounding tissues [51,52]. Both characteristics, added to the fact that the unwanted Tyndall effect has not been reported with Belotero Ò Balance, makes the product an excellent option to treat tear trough deformity.…”

Section: Hyaluronic Acidmentioning

confidence: 96%

Dermal Fillers: An Update

2015

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Injection of dermal fillers is the second most frequent nonsurgical cosmetic procedure performed in the USA. Dermal fillers are an option in the treatment of volume deficiency, scars, and rhytides; facial sculpting; facial contouring; and augmentation of specific anatomical sites such as the lips. The number of injectable dermal fillers available on the market increases yearly. Dermatologists and cosmetic surgeons should regularly review treatment options to provide patients with safe and effective filler options. This paper extensively reviews the properties of the available fillers, such as their rheology, longevity, and adverse effects, and how these properties affect the choice of filler agent for a particular patient or a particular site. Also, trends in dermal filler injections are discussed.

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“…The differences in their respective properties have been described in the literature (Sundaram and Cassuto 2013 ;Sundaram et al 2010 ). We primarily use Restylane for revolumization in the upper and lower lids.…”

Section: Techniquementioning

confidence: 96%

Upper Eyelid Volumization with Hyaluronic Acid

Glasgold

Gerth

2014

Pearls and Pitfalls in Cosmetic Oculoplastic Surgery

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Biophysical Characteristics of Hyaluronic Acid Soft-Tissue Fillers and Their Relevance to Aesthetic Applications

Abstract: Rheologic evaluation reliably predicts tissue integration patterns and appropriate clinical applications of the studied fillers. Paradigms of layered filler placement can be designed to optimally address individual patient need.

Cited by 155 publications

References 19 publications

Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction

Injectable Shape-Memorizing Three-Dimensional Hyaluronic Acid Cryogels for Skin Sculpting and Soft Tissue Reconstruction

Dermal Fillers: An Update

Upper Eyelid Volumization with Hyaluronic Acid

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