Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy

Kanai, Tatsuaki; Endo, Masahiro; Minohara, Shinichi; Miyahara, Nobuyuki; Koyama-Ito, Hiroko; Tomura, H.; Matsufuji, Naruhiro; Futami, Yasuyuki; Fukumura, Akifumi; Hiraoka, Takeshi; Furusawa, Yoshiya; Andō, Kōichi; Suzuki, Masao; Soga, F.; Kawachi, Kiyomitsu

doi:10.1016/s0360-3016(98)00544-6

Cited by 795 publications

(654 citation statements)

References 13 publications

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“…The irradiation system and biophysical characteristics of heavy carbon-ion beam irradiation have been described (17,18). Briefly, the initial energy of the heavy carbon-ion beam was 290 MeV/n.…”

Section: Human Esophageal Squamous Cell Carcinoma Cell Line (Te-2)mentioning

confidence: 99%

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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Abstract. Heavy carbon-ion beam therapy has revealed several potential advantages over X-rays. Heavy-ion therapy has been applied for various solid tumors including esophageal squamous cell carcinoma (SCC). Although the local control rate of carbon ion radiotherapy for esophageal cancer has revealed better rates than that of conventional radiotherapy, some patients have shown resistance to the treatment. No study has evaluated whether anti-cancer drugs can enhance the anti-tumor effect of heavy carbon-ion beam irradiation. Therefore, we evaluated the efficacy of docetaxel, fluorouracil, cisplatinum, doxorubicin and gemcitabine to enhance the anti-tumor effects of heavy carbon-ion beam irradiation on human esophageal SCC cells in both in vitro and in vivo experiments. Fluorouracil, cisplatinum, doxorubicin and gemcitabine showed only additive anti-tumor effects. On the other hand, growth suppression was significantly potentiated by the combined treatment with heavy carbon-ion beam and docetaxel as compared to that treated with either agent alone. These data suggest that heavy carbon-ion beam irradiation combined with docetaxel may be a potentially useful therapeutic strategy for locally advanced esophageal SCC.

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Section: Human Esophageal Squamous Cell Carcinoma Cell Line (Te-2)mentioning

confidence: 99%

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Kitabayashi

Shimada²,

Yamada³

et al. 2006

Oncol Rep

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“…At the HIMAC facility in Chiba, Japan, and the HYOGO ion beam medical center in Hyogo, Japan, carbon beam radiotherapy uses wobbler magnets and a scatterer to flatten the radiation field. The depth-dose distribution of the beam is modified with passive beam filters to spread-out the Bragg peak [58]. The Japanese program has concentrated primarily on tumors of the chest and abdomen (lung, liver, uterine cervix, and prostate), and also treated head and neck patients.…”

Section: Carbon Ion Beam Radiation Therapymentioning

confidence: 99%

“…The Japanese program has concentrated primarily on tumors of the chest and abdomen (lung, liver, uterine cervix, and prostate), and also treated head and neck patients. Overall carbon treatment schedules have been successfully shortened to one to three weeks for liver and lung cancer, which minimized the proliferation of tumor cells during treatments [58]. The Japanese program was a pioneer in the development of particle beam delivery gated to respiration.…”

Section: Carbon Ion Beam Radiation Therapymentioning

confidence: 99%

Late effects from hadron therapy

Blakely

Chang

2004

Radiotherapy and Oncology

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Successful cancer patient survival and local tumor control from hadron radiotherapy warrant a discussion of potential secondary late effects from the radiation. The study of late-appearing clinical effects from particle beams of protons, carbon, or heavier ions is a relatively new field with few data. However, new clinical information is available from pioneer hadron radiotherapy programs in the USA, Japan, Germany and Switzerland. This paper will review available data on late tissue effects from particle radiation exposures, and discuss its importance to the future of hadron therapy.Potential late radiation effects are associated with irradiated normal tissue volumes at risk that in many cases can be reduced with hadron therapy. However, normal tissues present within hadron treatment volumes can demonstrate enhanced responses compared to conventional modes of therapy. Late endpoints of concern include induction of secondary cancers, cataract, fibrosis, neurodegeneration, vascular damage, and immunological, endocrine and hereditary effects. Low-dose tissue effects at tumor margins need further study, and there is need for more acute molecular studies underlying late effects of hadron therapy.2

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“…The LEM is used clinically in the carbon ion beam Treatment Planning System at the Heidelberg Heavy Ion Therapy centre [19]. Alternatively, at the Heavy Ion Medical Accelerator (HIMAC) of NIRS in Chiba, Japan, the RBE 10 (RBE at 10% cell surviving fraction in Human Salivary Gland tumour cells [20] was evaluated by means of the Microdosimetric Kinetic Model (MKM), formulated by Hawkins [21,22] which is based on microdosimetric measurements.…”

Section: Introductionmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy

Cited by 795 publications

References 13 publications

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation

Late effects from hadron therapy

Review of Geant4-DNA applications for micro and nanoscale simulations

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