Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Habib Bashour,
Eva Smorodina,
Matteo Pariset
et al.
Abstract:Designing effective monoclonal antibody (mAb) therapeutics face a significant challenge known as “developability”, which reflects an antibody’s ability to progress through development stages based on its physicochemical properties. While natural antibody repertoires may provide valuable guidance for antibody selection, we lack a comprehensive understanding of natural developability parameter (DP) plasticity (redundancy, predictability, sensitivity) and how the DP landscapes of human-engineered and natural anti… Show more
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