Biophysical and morphological changes in the stratum corneum lipids induced by UVB irradiation

Jiang, Shengwei; Chen, Jie Yu; Lu, Zhen; Yao, Jie; Fa, Dun; Zhou, Xiao

doi:10.1016/j.jdermsci.2006.05.012

Cited by 51 publications

(53 citation statements)

References 33 publications

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“…It has previously been demonstrated that irradiation with suberythemal doses of either UVA or UVB yielded an increase in the amount of stratum corneum lipids, especially the ceramide fraction, implying that the increase in the stratum corneum lipids after UVB irradiation is indicative of a local change in the biosynthesis or degradation of these compounds 62 . Moreover, abnormal stratum corneum lipid profiles can be associated with defective permeability barrier function in common skin disease like eczema and psoriasis, both of which exhibit hyperproliferation, impaired epidermal differentiation, and barrier dysfunction 63 .…”

Section: Discussionmentioning

confidence: 99%

“…It has been speculated that acylglucocylceramide exists as a common precursor within lamellar granules for both covalently bound ceramide and acylceramide 62 . UVB irradiation might result in the accumulation of acylglucocylceramide and in a preferential switch toward the biosynthesis of acylceramide, which leads to the increase in acylceramide level, resulting in abnormal ceramide: free sterols: fatty acid ratios and ultimately morphological alterations of the stratum corneum lipidic structures, as the imbalanced lipid mixture may not be completely integrated into a lipid bilayer configuration.…”

Section: Discussionmentioning

confidence: 99%

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Raman spectroscopic mapping for the analysis of solar radiation induced skin damage

Ali¹,

Bonnier²,

Ptasiński³

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Raman spectroscopic mapping for the analysis of solar radiation induced skin damage

Ali¹,

Bonnier²,

Ptasiński³

et al. 2013

Analyst

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“…UVB irradiation causes a decline in the skin barrier function via down-regulation of TGase-1 gene [23], biophysical changes in the SC lipids [27], and perturbation of tight junction (TJ) function [28]. Further, TGase-1 is downregulated in skin reconstructed in vitro after UVB exposure, and the expression levels of precursors of CE formation were also altered [29].…”

Section: Discussionmentioning

confidence: 99%

Dietary Glucosylceramide Enhances Cornified Envelope Formation via Transglutaminase Expression and Involucrin Production

Hasegawa¹,

Shimada

Uchiyama³

et al. 2011

Lipids

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In this study, we investigated whether dietary glucosylceramide (GlcCer) and its metabolite sphingoid bases, sphingosine (SS), phytosphingosine (PS), sphingadienine (SD) and 4-hydroxysphingenine (4HS), influence cornified envelope (CE) formation. CE is formed during terminal differentiation of the epidermis through crosslinking of specific precursor proteins by transglutaminases (TGases), and is essential for the skin's barrier function. Oral administration of GlcCer (0.25 mg/day) for 14 consecutive days dramatically reduced transepidermal water loss, an indicator of the skin barrier condition, in hairless mice with barrier perturbation induced by single-dose ultraviolet B (UVB) irradiation. The GlcCer treatment also increased the level of TGase-1 mRNA in UVB-irradiated murine epidermis approximately 1.6-fold compared with the control. Further, all four sphingoid bases at 1 μM concentration enhanced CE formation of cultured normal human keratinocyte cells. Among them, SS, PS and SD, but not 4HS, stimulated production of involucrin, one of the CE major precursor proteins. SD increased the expression of TGase-1 mRNA, while SS increased the expression of TGase-3 mRNA. These results indicate that the skin barrier improvement induced by oral GlcCer treatment might be at least partly due to a reinforcement of CE formation in the epidermis mediated by sphingoid bases metabolically derived from GlcCer.

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“…However, studies here show a significant delay in barrier recovery following higher doses of sun exposure. Previous studies showed that UVB radiation alters SC lipid structure and induces disorganized lamellar body and SC intercellular membrane bilayers in addition to disrupting barrier function [43,44] . Moreover, UVB radiation increases SC pH, which, in turn, delays barrier recovery and increases epidermal desquamation [45,46] .…”

Section: Discussionmentioning

confidence: 99%

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

Liu

Fluhr

Shu-min

et al. 2010

Skin Pharmacol Physiol

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Previous studies have demonstrated that UVB radiation changes the epidermal permeability barrier and stratum corneum (SC) hydration. It is well known that sun exposure causes erythema, sunburn and melanoma. However, whether daily sun exposure alters SC integrity and epidermal permeability barrier function is largely unknown, especially in Chinese subjects. In the present study, we assess the SC integrity, SC hydration and epidermal permeability barrier function following various doses of sun exposure. A total of 258 subjects (124 males and 134 females) aged 18–50 years were enrolled. A multifunctional skin physiology monitor (Courage & Khazaka MPA5) was used to measure SC hydration and transepidermal water loss (TEWL) on the forearms. In males, basal TEWL was higher with higher doses of sun exposure than with lower doses and control, whereas in females, basal TEWL was higher with lower doses of sun exposure than with higher doses and control. In the group with higher doses of sun exposure, TEWL in females was significantly lower than that in males. The barrier recovery was faster in females than in males in both control and lower-dose groups. In both males and females, barrier recovery was delayed with higher doses of sun exposure. In males, sun exposure did not alter SC hydration, while in females SC hydration was lower with lower doses of sun exposure as compared with control and higher doses of sun exposure. These results demonstrated that sun-induced changes in SC function and SC hydration vary with gender and the extent of sun exposure.

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Biophysical and morphological changes in the stratum corneum lipids induced by UVB irradiation

Cited by 51 publications

References 33 publications

Raman spectroscopic mapping for the analysis of solar radiation induced skin damage

Raman spectroscopic mapping for the analysis of solar radiation induced skin damage

Dietary Glucosylceramide Enhances Cornified Envelope Formation via Transglutaminase Expression and Involucrin Production

Sun-Induced Changes in Stratum Corneum Function Are Gender and Dose Dependent in a Chinese Population

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