Biophysical and biochemical nature of amorphous protein oligomers determines the strength of immune response and the generation of T‐cell memory
Md. Golam Kibria,
Yukari Shiwaku,
Subbaian Brindha
et al.
Abstract:Here, we used domain 3 of dengue virus serotype 3 envelope protein (D3ED3), a natively folded globular low‐immunogenicity protein, to ask whether the biophysical nature of amorphous oligomers can affect immunogenicity. We prepared nearly identical 30 ~ 50 nm‐sized amorphous oligomers in five distinct ways and looked at any correlation between their biophysical properties and immunogenicity. One oligomer type was produced using our SCP tag (solubility controlling peptide) made of 5 isoleucines (C5I). The others… Show more
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