Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques

Guedes, Beatriz Neris; Fathi, Faezeh; Silva, Amélia M.; Santini, Antonello; Oliveira, M. Beatriz P.P.; Souto, Eliana B.

doi:10.1007/s00217-023-04314-w

Cited by 5 publications

(1 citation statement)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Citric acid has gained attention in the pharmaceutical and cosmetical field as a remarkable excipient due to its useful properties, such as biocompatibility and biodegradability, being a pH adjuster, crosslinker, and chelating and stabilizing agent, and also being a natural compound [57,58]. Regarding the biological effects possessed by the extracts from different parts of Opuntia ficus-indica, several studies showed its antioxidant, antibacterial, and anti-inflammatory activities, as well as its tissue regeneration capacity [59][60][61][62].…”

Section: Introductionmentioning

confidence: 99%

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Moraru,

Dima,

Tritean

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Biocompatible drug-delivery systems for soft tissue applications are of high interest for the medical and pharmaceutical fields. The subject of this research is the development of hydrogels loaded with bioactive compounds (inulin, thyme essential oil, hydro-glycero-alcoholic extract of Vitis vinifera, Opuntia ficus-indica powder, lactic acid, citric acid) in order to support the vaginal microbiota homeostasis. The nanofibrillar phyto-hydrogel systems developed using the biocompatible polymers chitosan (CS), never-dried bacterial nanocellulose (NDBNC), and Poloxamer 407 (PX) incorporated the water-soluble bioactive components in the NDBNC hydrophilic fraction and the hydrophobic components in the hydrophobic core of the PX fraction. Two NDBNC-PX hydrogels and one NDBNC-PX-CS hydrogel were structurally and physical-chemically characterized using Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and rheology. The hydrogels were also evaluated in terms of thermo-responsive properties, mucoadhesion, biocompatibility, and prebiotic and antimicrobial effects. The mucin binding efficiency of hydrogel base systems was determined by the periodic acid/Schiff base (PAS) assay. Biocompatibility of hydrogel systems was determined by the MTT test using mouse fibroblasts. The prebiotic activity was determined using the probiotic strains Limosilactobacillus reuteri and Lactiplantibacillus plantarum subsp. plantarum. Antimicrobial activity was also assessed using relevant microbial strains, respectively, E. coli and C. albicans. TEM evidenced PX micelles of around 20 nm on NDBNC nanofibrils. The FTIR and XRD analyses revealed that the binary hydrogels are dominated by PX signals, and that the ternary hydrogel is dominated by CS, with additional particular fingerprints for the biocompounds and the hydrogel interaction with mucin. Rheology evidenced the gel transition temperatures of 18–22 °C for the binary hydrogels with thixotropic behavior and, respectively, no gel transition, with rheopectic behavior for the ternary hydrogel. The adhesion energies of the binary and ternary hydrogels were evaluated to be around 1.2 J/m2 and 9.1 J/m2, respectively. The hydrogels exhibited a high degree of biocompatibility, with the potential to support cell proliferation and also to promote the growth of lactobacilli. The hydrogel systems also presented significant antimicrobial and antibiofilm activity.

show abstract

Section: Introductionmentioning

confidence: 99%

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Moraru,

Dima,

Tritean

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Application of Peptides for the Treatment of Diabetes: A Plant-Based Bioactive Material

Malhotra,

Rana,

Himani

et al. 2024

Biosystems, Biomedical &Amp; Drug Delivery Systems

View full text Add to dashboard Cite

Activated Opuntia ficus-indica as an efficient adsorbent for iodine and heavy metals Cr(III), Cu(II) and Ni(II) ions uptake for wastewater treatment

Alzharani

2024

J.Umm Al-Qura Univ. Appll. Sci.

View full text Add to dashboard Cite

Water pollution by heavy metals or iodine is a serious environmental issue that poses a threat to human health and ecosystems. Therefore, there is a need for developing efficient and low-cost methods for removing heavy metals and iodine from water sources. Activated Opuntia ficus-indica (AOFI) has been used for various purposes such as food, medicine, cosmetics, biofuel, and soil stabilization. The aim of this study was to investigate the feasibility of using AOFI as an adsorbent for removing heavy metals; e.g. Cr(III), Pb(II), and Cu(II) and iodine from water. The leaves of AOFI that were collected from Al-Baha city, KSA, were carbonized and characterized using FTIR spectroscopy and TGA analysis. Then uptake experiments were performed to evaluate the effects of various parameters such as pH, contact time, initial concentration, and temperature on the removal uptake by AOFI. Also the thermodynamic and kinetic parameters of the adsorption process had been calculated. The adsorption capacity of AOFI and OFI against iodine, Cr(III), Pb(II), and Cu(II) had been calculated. The results showed that; AOFI has adsorption capacity 1.14, 1.14, and 1.16 times higher than OFI, for Cr(III), Pb(II), and Cu(II), respectively, and 1.05 times higher than OFI, for iodine uptake. The findings indicated that AOFI exhibited remarkable efficacy in the metal ions uptake, achieving uptake efficiency up to 70%. Additionally, AOFI demonstrated notable efficiency in iodine uptake, reaching up to 60%. These results underscore the high uptake efficiency of AOFI for both metal ions and iodine, emphasizing its potential as an effective adsorbent for water treatment applications. This study is novel because it is the first to report the adsorption of heavy metals; such as Cr(III), Pb(II), and Cu(II) and iodine by AOFI.

show abstract

Biopharmaceutical applications of Opuntia ficus-indica: bibliometric map, bioactivities and extraction techniques

Cited by 5 publications

References 106 publications

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Bioactive-Loaded Hydrogels Based on Bacterial Nanocellulose, Chitosan, and Poloxamer for Rebalancing Vaginal Microbiota

Application of Peptides for the Treatment of Diabetes: A Plant-Based Bioactive Material

Activated Opuntia ficus-indica as an efficient adsorbent for iodine and heavy metals Cr(III), Cu(II) and Ni(II) ions uptake for wastewater treatment

Contact Info

Product

Resources

About