Bioorthogonal labeling of chitin in pathogenic Candida species reveals biochemical mechanisms of hyphal growth and homeostasis
Caroline Williams,
Bella R. Carnahan,
Stephen N. Hyland
et al.
Abstract:Pathogenic fungi rely on the cell wall component, chitin, for critical structural and immunological functions. Here a chitin labeling method to visualize the hyphal pathogenic response was developed. The data show that filamentous fungi,Candida albicans, transportN-acetylglucosamine (NAG) bio-orthogonal probes and incorporate them into the cell wall, indicating the probes utility forin vivostudy of the morphological, pathogenic switch. As yeast reside in complex microenvironments, The data show that the opport… Show more
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