Bioorthogonal Chemistry and Its Applications

Bird, Robert E.; Lemmel, S. A.; Yu, Xiang; Zhou, Qiongqiong

doi:10.1021/acs.bioconjchem.1c00461

Cited by 181 publications

(176 citation statements)

References 161 publications

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“…Most of the methods described above present an excellent orthogonal reactivity 74,75 that revealed ideal to increase the molecular diversity of multivalent systems. After having demonstrated the compatibility of OL and CuAAC and the possibility to use them in a sequential one-pot process, 76,77 Thomas et al exploited this dual strategy to synthesize hGCs.…”

Section: Orthogonal Ligation Strategiesmentioning

confidence: 99%

Multivalent glycocyclopeptides: conjugation methods and biological applications

et al. 2022

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Section: Orthogonal Ligation Strategiesmentioning

confidence: 99%

Multivalent glycocyclopeptides: conjugation methods and biological applications

et al. 2022

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“…Another report by Hudak et al shows the expanded capacity of metabolic labeling by using two different biorthogonal chemistry (azide-alkyne and cyclopropane-tetrazine conjugation) methods to visualize capsular polysaccharides, lipopolysaccharides, and peptidoglycans in three different color combinations [ 223 ]. However, the three-color combination approach only allows for in vitro imaging due to the strong scattering of red, blue, and green light by tissues [ 224 ]. Still, if only one specific biomolecule is needed for characterizing microbiota species, in vivo imaging and analysis of gut microbiota is feasible.…”

Section: Materials For Analysis and Imaging Of Gut Microbiomementioning

confidence: 99%

“…Still, if only one specific biomolecule is needed for characterizing microbiota species, in vivo imaging and analysis of gut microbiota is feasible. Future directions to further develop this metabolic labeling strategy may include the integration of quantum dots, plasmonic nanomaterials, upconversion, and radioactive nanoparticles that allow for deep-tissue imaging (e.g., NIR fluorescence and surface-enhanced Raman spectroscopy) while having sharp emission profiles [ 224 ].…”

Section: Materials For Analysis and Imaging Of Gut Microbiomementioning

confidence: 99%

Material Engineering in Gut Microbiome and Human Health

et al. 2022

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Tremendous progress has been made in the past decade regarding our understanding of the gut microbiome’s role in human health. Currently, however, a comprehensive and focused review marrying the two distinct fields of gut microbiome and material research is lacking. To bridge the gap, the current paper discusses critical aspects of the rapidly emerging research topic of “material engineering in the gut microbiome and human health.” By engaging scientists with diverse backgrounds in biomaterials, gut-microbiome axis, neuroscience, synthetic biology, tissue engineering, and biosensing in a dialogue, our goal is to accelerate the development of research tools for gut microbiome research and the development of therapeutics that target the gut microbiome. For this purpose, state-of-the-art knowledge is presented here on biomaterial technologies that facilitate the study, analysis, and manipulation of the gut microbiome, including intestinal organoids, gut-on-chip models, hydrogels for spatial mapping of gut microbiome compositions, microbiome biosensors, and oral bacteria delivery systems. In addition, a discussion is provided regarding the microbiome-gut-brain axis and the critical roles that biomaterials can play to investigate and regulate the axis. Lastly, perspectives are provided regarding future directions on how to develop and use novel biomaterials in gut microbiome research, as well as essential regulatory rules in clinical translation. In this way, we hope to inspire research into future biomaterial technologies to advance gut microbiome research and gut microbiome-based theragnostics.

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“…Bioorthogonal chemistries were initially applied to fundamental studies of biomolecules in live cells but have been rapidly expanded for biomaterial polymerization, crosslinking, and functional decoration [ 16 , 17 , 18 ]. While several such bioorthogonal biomaterials have been applied toward treating neuroinflammation or promoting neural tissue regeneration, it can be difficult to identify many of the references due to variations in diction or approach descriptions.…”

Section: Introductionmentioning

confidence: 99%

Clickable Biomaterials for Modulating Neuroinflammation

Cornelison

Fadel

2022

IJMS

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Crosstalk between the nervous and immune systems in the context of trauma or disease can lead to a state of neuroinflammation or excessive recruitment and activation of peripheral and central immune cells. Neuroinflammation is an underlying and contributing factor to myriad neuropathologies including neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease; autoimmune diseases like multiple sclerosis; peripheral and central nervous system infections; and ischemic and traumatic neural injuries. Therapeutic modulation of immune cell function is an emerging strategy to quell neuroinflammation and promote tissue homeostasis and/or repair. One such branch of ‘immunomodulation’ leverages the versatility of biomaterials to regulate immune cell phenotypes through direct cell-material interactions or targeted release of therapeutic payloads. In this regard, a growing trend in biomaterial science is the functionalization of materials using chemistries that do not interfere with biological processes, so-called ‘click’ or bioorthogonal reactions. Bioorthogonal chemistries such as Michael-type additions, thiol-ene reactions, and Diels-Alder reactions are highly specific and can be used in the presence of live cells for material crosslinking, decoration, protein or cell targeting, and spatiotemporal modification. Hence, click-based biomaterials can be highly bioactive and instruct a variety of cellular functions, even within the context of neuroinflammation. This manuscript will review recent advances in the application of click-based biomaterials for treating neuroinflammation and promoting neural tissue repair.

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Bioorthogonal Chemistry and Its Applications

Cited by 181 publications

References 161 publications

Multivalent glycocyclopeptides: conjugation methods and biological applications

Multivalent glycocyclopeptides: conjugation methods and biological applications

Material Engineering in Gut Microbiome and Human Health

Clickable Biomaterials for Modulating Neuroinflammation

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