Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges

Min, Qingqiang; Ji, Xingyue

doi:10.1021/acs.jmedchem.3c01459

J. Med. Chem.

2023

DOI: 10.1021/acs.jmedchem.3c01459

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Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges

Qingqiang Min,

Xingyue Ji

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2024

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Cited by 2 publications

References 136 publications

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Advances in Bioinspired Artificial System Enabling Biomarker‐Driven Therapy

Wang,

Zhong,

et al. 2024

Chemistry A European J

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Bioinspired molecular engineering strategies have emerged as powerful tools that significantly enhance the development of novel therapeutics, improving efficacy, specificity, and safety in disease treatment. Recent advancements have focused on identifying and utilizing disease‐associated biomarkers to optimize drug activity and address challenges inherent in traditional therapeutics, such as frequent drug administrations, poor patient adherence, and increased risk of adverse effects. In this review, we provide a comprehensive overview of the latest developments in bioinspired artificial systems (BAS) that use molecular engineering to tailor therapeutic responses to drugs in the presence of disease‐specific biomarkers. We examine the transition from open‐loop systems, which rely on external cues, to closed‐loop feedback systems capable of autonomous self‐regulation in response to disease‐associated biomarkers. We detail various BAS modalities designed to achieve biomarker‐driven therapy, including activatable prodrug molecules, smart drug delivery platforms, autonomous artificial cells, and synthetic receptor‐based cell therapies, elucidating their operational principles and practical in vivo applications. Finally, we discuss the current challenges and future perspectives in the advancement of BAS‐enabled technology and envision that ongoing advancements toward more programmable and customizable BAS‐based therapeutics will significantly enhance precision medicine.

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Advances in Bioinspired Artificial System Enabling Biomarker‐Driven Therapy

Wang,

Zhong,

et al. 2024

Chemistry A European J

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Controlled bioorthogonal activation of Bromodomain-containing protein 4 degrader by co-delivery of PROTAC and Pd-catalyst for tumor-specific therapy

Li,

Jiang,

Yuan

et al. 2024

Journal of Controlled Release

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Bioorthogonal Bond Cleavage Chemistry for On-demand Prodrug Activation: Opportunities and Challenges

Cited by 2 publications

References 136 publications

Advances in Bioinspired Artificial System Enabling Biomarker‐Driven Therapy

Advances in Bioinspired Artificial System Enabling Biomarker‐Driven Therapy

Controlled bioorthogonal activation of Bromodomain-containing protein 4 degrader by co-delivery of PROTAC and Pd-catalyst for tumor-specific therapy

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