Bioorganic and Medicinal Organogermanium Chemistry

Nakamura, Takashi; Shimada, Yasuhiro; Sato, Katsuyuki

doi:10.1002/9781119613466.ch19

Cited by 3 publications

(6 citation statements)

References 60 publications

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“…K. Asai was the first to foresee the pharmaceutical potential of the Ge-132 [ 24 ]. The history of Ge-132 is now well-known (see e.g., [ 6 , 7 , 24 , 70 , 71 ]). It was Ge-132 that led to the active study of biological activity of germanium compounds and their application in medical practice, especially in complex cancer therapy [ 7 , 19 , 31 , 36 , 72 ].…”

Section: Historical Digression and Toxicity Of Germanium Compoundsmentioning

confidence: 99%

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Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков

Popov

2023

Biomedicines

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and briefly suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and suppressed for a long time.

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Section: Historical Digression and Toxicity Of Germanium Compoundsmentioning

confidence: 99%

“…Finally, Ge-132, together with hydroxyapatite, is proposed for the recovery and regeneration of mineralized tissues, particularly bone marrow [ 97 ]. The biological activity of Ge-132 is described in detail in the recently published monograph [ 71 ].…”

Section: Organic Germanium Compoundsmentioning

confidence: 99%

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков

Popov

2023

Biomedicines

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“…This article also does not mention the work of Russian chemists, but is cited by many authors as the first publication on Ge-132 synthesis, although the true history of Ge-132 is now well known (see e.g. [6,7,24,75,76]).…”

Section: DI Mendeleev (Left) and C Winklermentioning

confidence: 99%

“…Finally, Ge-132 together with hydroxyapatite is proposed for the recovery and regeneration of mineralized tissues, in particular bone marrow [102]. The biological activity of Ge-132 is described in detail in the recently published monograph [76].…”

Section: Germanium Sesquioxidesmentioning

confidence: 99%

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Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков¹,

Popov²

2023

Preprint

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and hushed up for a long time.

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The role of germanium in diseases: exploring its important biological effects

Luo,

Sun,

Kong

et al. 2023

J Transl Med

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With the development of organic germanium and nanotechnology, germanium serves multiple biological functions, and its potential value in biochemistry and medicine has increasingly captured the attention of researchers. In recent years, germanium has gradually gained significance as a material in the field of biomedicine and shows promising application prospects. However, there has been a limited amount of research conducted on the biological effects and mechanisms of germanium, and a systematic evaluation is still lacking. Therefore, the aim of this review is to systematically examine the application of germanium in the field of biomedicine and contribute new insights for future research on the functions and mechanisms of germanium in disease treatment. By conducting a comprehensive search on MEDLINE, EMBASE, and Web of Science databases, we systematically reviewed the relevant literature on the relationship between germanium and biomedicine. In this review, we will describe the biological activities of germanium in inflammation, immunity, and antioxidation. Furthermore, we will discuss its role in the treatment of neuroscience and oncology-related conditions. This comprehensive exploration of germanium provides a valuable foundation for the future application of this element in disease intervention, diagnosis, and prevention.

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Bioorganic and Medicinal Organogermanium Chemistry

Cited by 3 publications

References 60 publications

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Physiological Activity of Trace Element Germanium Including Anticancer Properties

The role of germanium in diseases: exploring its important biological effects

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