Bionic reconstruction to restore hand function after brachial plexus injury: a case series of three patients

Aszmann, Oskar C.; Roche, Aidan D.; Salminger, Stefan; Paternostro-Sluga, Tatjana; Herceg, Malvina; Sturma, Agnes; Höfer, Christian; Farina, Dario

doi:10.1016/s0140-6736(14)61776-1

Cited by 128 publications

(126 citation statements)

References 25 publications

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“…Even in the absence of target muscle tissue, this may be obtained either with transplants of small muscle portions 33 or, in the future, by growing muscle tissue around the terminal portion of the nerve 34 . Therefore, the proposed system should be seen as a general neural interface that accurately decodes the efferent activity of nerves without inserting electrodes into nerves.…”

Section: Methodsmentioning

confidence: 99%

Man/machine interface based on the discharge timings of spinal motor neurons after targeted muscle reinnervation

et al. 2017

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The intuitive control of upper - limb prostheses requires a man/machine interface that directly exploits biological signals. Here, we define and experimentally test an offline man/machine interface that takes advantage of the discharge timings of spinal moto r neurons. The motor - neuron behaviour is identified by deconvolution of the electrical activity of muscles reinnervated by nerves of a missing limb in patients with amputation at the shoulder or humeral level. We mapped the series of motor - neuron discharge s into control commands across multiple degrees of freedom via the offline application of direct proportional control, pattern recognition and musculoskeletal modelling. A series of experiments performed on six patients reveal that the man/machine interfac e has superior offline performance than conventional direct electromyographic control applied after targeted muscle innervation. The combination of surgical procedures, decoding and mapping into effective commands constitutes an interface with the output l ayers of the spinal cord circuitry that allows for the intuitive control of multiple degrees of freedom

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Section: Methodsmentioning

confidence: 99%

Man/machine interface based on the discharge timings of spinal motor neurons after targeted muscle reinnervation

et al. 2017

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“…Dies gilt z. B. für massive Verletzungen des Plexus brachialis, aber auch für elektrische Verbrennungs-, Explosions-oder Avulsionstraumen, um nur ein paar wesentliche Verletzungsmuster zu nennen [3]. Auch in diesen Fällen hat die prothetische Rekonstruktion in den letzten Jahren einen immer höheren Stellenwert erlangt [3].…”

Section: Die Funktionslose Handunclassified

“…B. für massive Verletzungen des Plexus brachialis, aber auch für elektrische Verbrennungs-, Explosions-oder Avulsionstraumen, um nur ein paar wesentliche Verletzungsmuster zu nennen [3]. Auch in diesen Fällen hat die prothetische Rekonstruktion in den letzten Jahren einen immer höheren Stellenwert erlangt [3]. Keinesfalls sollen und können prothetische Möglichkeiten mit einer suffizienten biologischen Rekonstruktion konkurrieren,jedochsollensie dasSpektrum erweitern und am Ende der biologisch rekonstruktiven Leiter eine sinnvolle Alternative bzw.…”

Section: Die Funktionslose Handunclassified

“…Keinesfalls sollen und können prothetische Möglichkeiten mit einer suffizienten biologischen Rekonstruktion konkurrieren,jedochsollensie dasSpektrum erweitern und am Ende der biologisch rekonstruktiven Leiter eine sinnvolle Alternative bzw. Erweiterung zur Wiederherstellung einer Extremitätenfunktion bieten [3]. In diesen Fällen dient die Prothese als Rekonstruktion einer Hilfshand bzw.…”

Section: Die Funktionslose Handunclassified

“…Die Rekonstruktion derart komplexer Defekte an der oberen Extremität, sei es eine traumatische Amputation oder eine funktionslose Hand, erfordert eine interdisziplinäre Zusammenarbeit und in manchen Fällen auch unkonventionelle Methoden [3]. Diesbezüglich hat die Prothesenversorgung in den letzten Jahren einen immer höheren und besonderen Stellenwert erlangt.…”

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Prothetische Rekonstruktion der oberen Extremität

et al. 2016

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Transplantation

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2015

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The first successful human corneal transplant was around 1900 by Zirm, corneal xenografting having been tried as early as 1837 but without notable success. From the early 1950s, Calne envisaged kidney transplantation as a practicable therapy; and surgical, immunological, and immunosuppressive advances made it so by the mid‐1980s. By 1970, Barnard had pioneered heart transplantation; and liver transplantation was also under way. Xenografting from transgenic pigs was an unrealized challenge of the next decades, together with improvements in unrelated donor bone marrow transplantation and therapeutic exploitation of stem cell banking. Interventional ventilation has not been proceeded with, and there has been more emphasis on realizing national potentials for living related kidney transplantation together with ethical and matching safeguards for unrelated living renal transplantation. By 1990, transplantation had achieved 1‐year graft survival rates of 80% or more for most solid organs, and had done so through surgical innovation, advances in immunosuppression, beneficial and favorable matching of kidney donor to recipient, better preservation solutions, and by studying center variation in donor rates as well as in transplant outcome. In the 1990s, shortage of cadaveric donor organs was a limiting factor which the use of split livers or of domino heart transplants from cystic fibrosis heart‐lung block recipients mitigated only very partially. Epidemiological studies monitor malignancies secondary to immunosuppression. Quality of life as well as length of life ( see Life Expectancy ) is improved by transplantation. Statistical science has underpinned much of the above progress. The past decade has seen transplant organizations internationally seeking to increase the equity and transparency as well as efficiency (e.g., in terms of quality‐adjusted life‐years) of their policies for national (and local) allocation of cadaveric donor organs.

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Bionic reconstruction to restore hand function after brachial plexus injury: a case series of three patients

Cited by 128 publications

References 25 publications

Man/machine interface based on the discharge timings of spinal motor neurons after targeted muscle reinnervation

Man/machine interface based on the discharge timings of spinal motor neurons after targeted muscle reinnervation

Prothetische Rekonstruktion der oberen Extremität

Transplantation

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