Bionic Design, Materials and Performance of Bone Tissue Scaffolds

Wu, Tong; Yu, Suihuai; Chen, Dengkai; Wang, Yanen

doi:10.3390/ma10101187

Cited by 74 publications

(43 citation statements)

References 62 publications

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“…Recently, smart artificial bone scaffolds were prepared to mimic the composition and structural characteristics of natural bone using the principles of biomimetics, nano-assembly technology and additive manufacturing techniques. 25 Specific molecular recognition signals, such as peptides, growth factors and genes, were immobilized on the scaffold. Biomimetic porous poly(lactide-co-glycolide) (PLGA) microspheres coupled with peptides were used to construct biomimetic environments for tissue engineering.…”

Section: Smart Scaffold Constructs With Stem Cells For Bone Tissue Enmentioning

confidence: 99%

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

et al. 2018

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Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals. Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material’s responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.

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Section: Smart Scaffold Constructs With Stem Cells For Bone Tissue Enmentioning

confidence: 99%

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

et al. 2018

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“…Most of the optimization studies reported in the literature aim to minimize the difference between the equivalent mechanical properties of the scaffold and those of the tissue within which it is implanted. In one word, such studies that consider scaffold stiffness as the design variable aim to minimize the effects of stress shielding at the bone/scaffold interface [32,33]. Optimization strategies based on the compressive modulus expressed as a ratio between third principal stress and the prescribed compressive strain were also utilized to optimize the geometry of scaffolds fabricated with the FDM technique [34].…”

Section: Introductionmentioning

confidence: 99%

Mechanobiological Approach to Design and Optimize Bone Tissue Scaffolds 3D Printed with Fused Deposition Modeling: A Feasibility Study

et al. 2020

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In spite of the rather large use of the fused deposition modeling (FDM) technique for the fabrication of scaffolds, no studies are reported in the literature that optimize the geometry of such scaffold types based on mechanobiological criteria. We implemented a mechanobiology-based optimization algorithm to determine the optimal distance between the strands in cylindrical scaffolds subjected to compression. The optimized scaffolds were then 3D printed with the FDM technique and successively measured. We found that the difference between the optimized distances and the average measured ones never exceeded 8.27% of the optimized distance. However, we found that large fabrication errors are made on the filament diameter when the filament diameter to be realized differs significantly with respect to the diameter of the nozzle utilized for the extrusion. This feasibility study demonstrated that the FDM technique is suitable to build accurate scaffold samples only in the cases where the strand diameter is close to the nozzle diameter. Conversely, when a large difference exists, large fabrication errors can be committed on the diameter of the filaments. In general, the scaffolds realized with the FDM technique were predicted to stimulate the formation of amounts of bone smaller than those that can be obtained with other regular beam-based scaffolds.

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“…In these cases, tissue engineering has been shown to offer promising approaches for bone regeneration, most of which are based on replacement with biomaterials that provide specific environments that promote bone formation. The ideal biomaterial should not only be biocompatible and safe, but should be osteoinductive and osteoconductive, also improving cell viability, adhesion, proliferation and osteogenic differentiation [2,3].…”

Section: Introductionmentioning

confidence: 99%

Could the Enrichment of a Biomaterial with Conditioned Medium or Extracellular Vesicles Modify Bone-Remodeling Kinetics during a Defect Healing? Evaluations on Rat Calvaria with Synchrotron-Based Microtomography

et al. 2020

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Tissue engineering has been shown to offer promising approaches for bone regeneration, mostly based on replacement with biomaterials that provide specific environments and support for bone growth. In this context, we previously showed that mesenchymal stem cells (MSCs) and their derivatives, such as conditioned medium (CM) and extracellular vesicles (EV), when seeded on collagen membranes (COL) or polylactide (PLA) biomaterials, are able to favor bone tissue regeneration, especially evidenced in animal model calvary defects. In the present study, we investigated whether the enrichment of a rat calvary defect site with CM, EVs and polyethylenimine (PEI)-engineered EVs could substantially modify the bone remodeling kinetics during defect healing, as these products were reported to favor bone regeneration. In particular, we focused the study, performed by synchrotron radiation-based high-resolution tomography, on the analysis of the bone mass density distribution. We proved that the enrichment of a defect site with CM, EVs and PEI-EVs substantially modifies, often accelerating, bone remodeling kinetics and the related mineralization process during defect healing. Moreover, different biomaterials (COL or PLA) in combination with stem cells of different origin (namely, human periodontal ligament stem cells-hPDLSCs and human gingival mesenchymal stem cells-hGMSCs) and their own CM, EVs and PEI-EVs products were shown to exhibit different mineralization kinetics.

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Bionic Design, Materials and Performance of Bone Tissue Scaffolds

Cited by 74 publications

References 62 publications

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

Mechanobiological Approach to Design and Optimize Bone Tissue Scaffolds 3D Printed with Fused Deposition Modeling: A Feasibility Study

Could the Enrichment of a Biomaterial with Conditioned Medium or Extracellular Vesicles Modify Bone-Remodeling Kinetics during a Defect Healing? Evaluations on Rat Calvaria with Synchrotron-Based Microtomography

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