Bionanomaterials: Thermal Stability of the Oleic Acid / alpha- and beta-cyclodextrin Complexes

Abstract

This paper presents the thermal stability of the oleic acid encapsulated in a- and b - cyclodextrin. The complexation of the oleic acid was achieved by the ethanol-water solution method and the nanoparticles were analyzed by DSC. The free oleic acid and the encapsulated one were subjected to the thermal degradation in the range of 50-150�C and the degradation products were identified and quantified by GC-MS analysis of the fatty acid esters obtained by deriving with methanol/boron trifluoride, both for free compounds and for the encapsulated ones. The oleic acid complexes were very stable in this range of temperature.

Design and evaluation of nanostructured lipid carriers loaded with Salvia officinalis extract for Alzheimer's disease treatment

“…The broad endothermic peak of Tween 80 at 73.33°C (Figure S1b in section Supporting information) is probably linked to its cloud point (around 65°C) when dehydration of the oxyethylene head groups of the molecule occurs 60 . DSC results for OA (Figure 4b) were consistent with literature data which points out the melting of the solid material that begins at 4°C 61 . The FSE thermal curve (Figure S1b in section Supporting information) exhibits broad endothermic peak at 130.83°C that is most likely attributed to volatile compounds present in the extract 62…”

“…58,59 The broad endothermic peak of Tween 80 at 73.33 C (Figure S1b in section Supporting information) is probably linked to its cloud point (around 65 C) when dehydration of the oxyethylene head groups of the molecule occurs. 60 DSC results for OA (Figure 4b) were consistent with literature data which points out the melting of the solid material that begins at 4 C. 61 The FSE thermal curve (Figure S1b in section Supporting information) exhibits broad endothermic peak at 130.83 C that is most likely attributed to volatile compounds present in the extract. 62 Except in the case of PL/OA (Figure S2a in section Supporting information), all other binary mixtures did not manifest significant changes in the thermal behavior despite the subtle shifting of the thermic events (Figure S2 in section Supporting information) as well as tenuous change in ΔH (Table 5) as a result of the variations of the concentration loadings.…”

Formulation of orodispersible atenolol-β-cyclodextrin tablets with co-processed crospovidone-croscarmellose sodium and poloxamer 188

“…This change means that the combination of atenolol and β-cyclodextrin has created a mixture of inclusion complex. The inclusion complex appears to have more than one endothermic peak that may be due to the dehydration from β-cyclodextrin in the range 70-110°C (Hadaruga et al, 2008).…”

Hepatoprotective Effects of Berberis vulgaris L. Extract/β Cyclodextrin on Carbon Tetrachloride–Induced Acute Toxicity in Mice

“…Bioactive compounds from Berberis vulgaris samples were separated by solid-liquid extraction in 96% ethanol, according to the method described by Hadaruga et al [ 32 ]. The final extract was subjected to HPLC analysis [ 32 ] followed by β-cyclodextrin nanoencapsulation [ 32 , 60 ]. The evaluation of Berberis vulgaris /β-cylodextrin complex formation was proved by differential scanning calorimetry (DSC) and thermogravimetry (TG) according to the previous study [ 32 ].…”