Bionanomaterials for cancer therapy

Ganjali, Monireh; Sereshki, Mohammad Mahdi Adib; Ahmadinasab, Navid; Ghalandarzadeh, Arash; Aljabali, Alaa A. A.; Barhoum, Ahmed

doi:10.1016/b978-0-12-823915-5.00015-0

Cited by 3 publications

(3 citation statements)

References 124 publications

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“…In this class, nanotubes, nanorods, nanowires, and nanofibers [25] are made of polymer, carbon, metals, and metal oxides and are good electron emitters in a weak electric field. Other 1D NMs, such as veils, mats, and nonwovens, are made of polymer nanofibers [26,27]. Due to their important surface-to-volume ratio and small pores, they are used for filtration, decontamination, and catalysis and as scaffolds and super-absorbents for wound dressing and tissue engineering [28].…”

Section: Classification Based On Dimensionalitymentioning

confidence: 99%

Nanoparticle and Nanostructure Synthesis and Controlled Growth Methods

et al. 2022

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Nanomaterials are materials with one or more nanoscale dimensions (internal or external) (i.e., 1 to 100 nm). The nanomaterial shape, size, porosity, surface chemistry, and composition are controlled at the nanoscale, and this offers interesting properties compared with bulk materials. This review describes how nanomaterials are classified, their fabrication, functionalization techniques, and growth-controlled mechanisms. First, the history of nanomaterials is summarized and then the different classification methods, based on their dimensionality (0–3D), composition (carbon, inorganic, organic, and hybrids), origin (natural, incidental, engineered, bioinspired), crystal phase (single phase, multiphase), and dispersion state (dispersed or aggregated), are presented. Then, the synthesis methods are discussed and classified in function of the starting material (bottom-up and top-down), reaction phase (gas, plasma, liquid, and solid), and nature of the dispersing forces (mechanical, physical, chemical, physicochemical, and biological). Finally, the challenges in synthesizing nanomaterials for research and commercial use are highlighted.

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Section: Classification Based On Dimensionalitymentioning

confidence: 99%

Nanoparticle and Nanostructure Synthesis and Controlled Growth Methods

et al. 2022

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“…Various techniques exist to modify zirconia implant surfaces [12][13][14][15][16][17][18][19]. However, these methods have numerous drawbacks, including time-consuming processing, harsh conditions, or requiring expensive masks and reagents, which restrict the plausible surface modification methods in industry, particularly in medical applications [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have documented the application of femtosecond lasers for surface texturing of hard ceramics [19][20][21]. However, limited attention has been given to periodic surface structuring, especially in relation to its potential for implant development.…”

Section: Introductionmentioning

confidence: 99%

Tailoring zirconia surface topography via femtosecond laser-induced nanoscale features: effects on osteoblast cells and antibacterial properties

Ghalandarzadeh,

Ganjali,

Hosseini

2024

Biomed. Mater.

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The performance and long-term durability of dental implants hinge on the quality of bone integration and their resistance to bacteria. This research aims to introduce a surface modification strategy for zirconia implants utilizing femtosecond laser ablation techniques, exploring their impact on osteoblast cell behavior and bacterial performance, as well as the integral factors influencing the soft tissue quality surrounding dental implants. Ultrafast lasers were employed to craft nanoscale groove geometries on zirconia surfaces, with thorough analyses conducted using x-ray diffraction, scanning electron microscopy, atomic force microscopy, and water contact angle measurements. The study evaluated the response of human fetal osteoblastic cell lines to textured zirconia ceramics by assessing alkaline phosphatase activity, collagen I, and interleukin 1β secretion over a 7 day period. Additionally, the antibacterial behavior of the textured surfaces was investigated using Fusobacterium nucleatum, a common culprit in infections associated with dental implants. Ciprofloxacin (CIP), a widely used antibacterial antibiotic, was loaded onto zirconia ceramic surfaces. The results of this study unveiled a substantial reduction in bacterial adhesion on textured zirconia surfaces. The fine biocompatibility of these surfaces was confirmed through the MTT assay and observations of cell morphology. Moreover, the human fetal osteoblastic cell line exhibited extensive spreading and secreted elevated levels of collagen I and interleukin 1β in the modified samples. Drug release evaluations demonstrated sustained CIP release through a diffusion mechanism, showcasing excellent antibacterial activity against pathogenic bacteria, including Streptococcus mutans, Pseudomonas aeruginosa, and Escherichia coli.

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Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy

Narayan

2024

Molecular Biomarkers for Cancer Diagnosis and Therapy

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Bionanomaterials for cancer therapy

Cited by 3 publications

References 124 publications

Nanoparticle and Nanostructure Synthesis and Controlled Growth Methods

Nanoparticle and Nanostructure Synthesis and Controlled Growth Methods

Tailoring zirconia surface topography via femtosecond laser-induced nanoscale features: effects on osteoblast cells and antibacterial properties

Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy

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