Biomonitoring Environmental Contamination With Pipping Black-Crowned Night Heron Embryos: Induction of Cytochrome P450

Rattner, Barnett A.; Melancon, Mark J.; Custer, Thomas W.; Hothem, Roger L.; King, Kirke A.; LeCaptain, Leonard J.; Spann, James W.; Woodin, Bruce R.; Stegeman, John J.

doi:10.1897/1552-8618(1993)12[1719:becwpb]2.0.co;2

Cited by 7 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several can be induced by light (37), whereas others are induced by plant stresses such as wounding, pathogens, or xenobiotic compounds (38). Xenobiotic induction of P450s in animal systems (such as birds and fish) has led to its use as an indicator of environmental contamination (39,40).…”

Section: Phytotransformation Enzymology and Biochemistrymentioning

confidence: 99%

Advances in Phytoremediation

Dietz¹,

Schnoor²

2001

Environmental Health Perspectives

100

View full text Add to dashboard Cite

Section: Phytotransformation Enzymology and Biochemistrymentioning

confidence: 99%

Advances in Phytoremediation

Dietz¹,

Schnoor²

2001

Environmental Health Perspectives

100

View full text Add to dashboard Cite

“…The pattern of P450-associated monooxygenase activity and P450 protein induction has been documented in pipping BCNH embryos following in ovo injection of methylcholanthrene and phenobarbital, and natural deposition of environmental pollutants in eggs [9,10]. Cytochrome P450 (viz., benzyloxyresorufin-and ethoxyresorufin-O-dealkylases and P450 1A protein) was highly inducible in embryos and was associated with concentrations of total polychlorinated biphenyls (PCBs), arylhydrocarbon (Ah) receptoractive PCB congeners, and toxic equivalents.…”

Section: Introductionmentioning

confidence: 99%

Cytochrome p450 and contaminant concentrations in nestling black‐crowned night‐herons and their interrelation with sibling embryos

Rattner¹,

Melancon²,

Custer³

et al. 1996

Enviro Toxic and Chemistry

Self Cite

View full text Add to dashboard Cite

Abstract-Hepatic cytochrome P450-associated monooxygenase activities were measured in 11-d-old nestling black-crowned nightherons (Nycticorax nycticorax) collected from a reference site (next to Chincoteague National Wildlife Refuge, VA, USA) and three contaminated sites (Cat Island, Green Bay, WI, USA; Bair Island, San Francisco Bay, CA, USA; and West Marin Island, San Francisco Bay, CA, USA). Arylhydrocarbon hydroxylase and benzyloxyresorufin-O-dealkylase activities of nestlings from contaminated sites were only slightly elevated (less than threefold) compared with the reference site. Organochlorine pesticide and total polychlorinated biphenyl (PCB) concentrations in nestlings were greatest at contaminated sites, although much lower than found in concurrently collected eggs and pipping embryos. Pollutant concentrations of nestlings were rarely associated with monooxygenase activity. In contrast, concurrently collected pipping heron embryos (often siblings of the nestlings) exhibited pronounced monooxygenase induction (means at contaminated sites were elevated up to sevenfold and values of some embryos exceeded 25-fold induction). Furthermore, monooxygenase activity of pipping embryos was significantly correlated with total PCBs, arylhydrocarbon receptor-active PCB congeners, and toxic equivalents. The modest monooxygenase responses of heron nestlings suggest that this biomarker may have only limited value during this rapid-growth life stage.

show abstract

“…Results of other studies, both in field and injection studies, have shown no difference in the same gross measurements, even though there were clear differences in contaminant levels, biochemical activities, and hatching success (Rattner, Melancon et al 1993). …”

Section: Bird Island Compared To Nausetmentioning

confidence: 83%

“…Furthermore, bird injection studies with phenobarbital (PB), a typical CYP2B inducer in mammals, have failed to induce PROD activity or CYP2 protein levels in ducks and other seabirds (Walker and Ronis 1989). However, although Rattner et al found only very low PROD activities in phenobarbital-injected black-crowned night herons, they detected elevated CYP2B-like proteins with polyclonal antibodies for CYP2B, suggesting the possibility that CYP2B-like proteins are inducible in aquatic birds (Rattner, Melancon et al 1993). In all these studies, PROD activity appears to be very low in piscivorous avian species, suggesting that it is not suitable as a biomarker for specific contaminant exposure.…”

Section: Bird Island Compared To Nausetmentioning

confidence: 99%

Feminization in common terns (Sterna hirunda) : relationship to persistent organic contaminants

Hart¹

1998

View full text Add to dashboard Cite

Biomonitoring Environmental Contamination With Pipping Black-Crowned Night Heron Embryos: Induction of Cytochrome P450

Cited by 7 publications

References 0 publications

Advances in Phytoremediation

Advances in Phytoremediation

Cytochrome p450 and contaminant concentrations in nestling black‐crowned night‐herons and their interrelation with sibling embryos

Feminization in common terns (Sterna hirunda) : relationship to persistent organic contaminants

Contact Info

Product

Resources

About