Biomolecules Produced by Mangrove-Associated Microbes

Xu, Jie

doi:10.2174/092986711798184307

Cited by 42 publications

(41 citation statements)

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“…Actinobacteria with type II PKS produce compounds that exhibit antibacterial, antitumour, antivirus and enzyme inhibitory activities (Hertweck et al, 2007;Xu, 2011). The type II PKS KSa gene was widely distributed in strains isolated from the two liquorice species.…”

Section: Discussionmentioning

confidence: 99%

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Zhao

Liao

et al. 2016

Microbiology

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A total of 218 actinobacteria strains were isolated from wild perennial liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza. inflate BAT. Based on morphological characteristics, 45 and 32 strains from G. inflate and G. glabra, respectively, were selected for further analyses. According to 16S rRNA sequence analysis, most of the strains belonged to genus Streptomyces and a few strains represented the rare actinobacteria Micromonospora, Rhodococcus and Tsukamurella. A total of 39 strains from G. inflate and 27 strains from G. glabra showed antimicrobial activity against at least one indicator organism. The range of the antimicrobial activity of the strains isolated from G. glabra and G. inflate was similar. A total of 34 strains from G. inflate and 29 strains from G. glabra carried at least one of the genes encoding polyketide synthases, non-ribosomal peptide synthetase and FADH 2 -dependent halogenase. In the type II polyketide synthase KSa gene phylogenetic analysis, the strains were divided into two major clades: one included known spore pigment production-linked KSa sequences and other sequences were linked to the production of different types of aromatic polyketide antibiotics. Based on the antimicrobial range, the isolates that carried different KSa types were not separated from each other or from the isolates that did not carry KSa. The incongruent phylogenies of 16S rRNA and KSa genes indicated that the KSa genes were possibly horizontally transferred. In all, the liquorice plants were a rich source of biocontrol agents that may produce novel bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Zhao

Liao

et al. 2016

Microbiology

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“…A clear difference between searching for enzymes and microorganisms in the mangroves versus in host-associated environments is that the latter represent “closed” environments, with minimal fluctuations in pH, temperature and other environmental parameters that might thus produce a more limited level microbial diversity. The greater microbial diversity of the mangroves and their associated microbial communities may be due to the numerous daily stresses that these organisms face (Xu 2011; Pointing et al 1999). …”

Section: Discussionmentioning

confidence: 99%

“…These microorganisms might therefore produce and secrete effective molecules or enzymes with promising biotechnological applications (Xu 2011). Mangroves sequester up to 25.5 million tonnes of carbon per year (Ong 1993) and provide more than 10% of the essential organic carbon to the global oceans (Dittmar et al 2006) as such, they are considered an environment of intense carbon flux.…”

Section: Discussionmentioning

confidence: 99%

A potential source for cellulolytic enzyme discovery and environmental aspects revealed through metagenomics of Brazilian mangroves

et al. 2013

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The mangroves are among the most productive and biologically important environments. The possible presence of cellulolytic enzymes and microorganisms useful for biomass degradation as well as taxonomic and functional aspects of two Brazilian mangroves were evaluated using cultivation and metagenomic approaches. From a total of 296 microorganisms with visual differences in colony morphology and growth (including bacteria, yeast and filamentous fungus), 179 (60.5%) and 117 (39.5%) were isolated from the Rio de Janeiro (RJ) and Bahia (BA) samples, respectively. RJ metagenome showed the higher number of microbial isolates, which is consistent with its most conserved state and higher diversity. The metagenomic sequencing data showed similar predominant bacterial phyla in the BA and RJ mangroves with an abundance of Proteobacteria (57.8% and 44.6%), Firmicutes (11% and 12.3%) and Actinobacteria (8.4% and 7.5%). A higher number of enzymes involved in the degradation of polycyclic aromatic compounds were found in the BA mangrove. Specific sequences involved in the cellulolytic degradation, belonging to cellulases, hemicellulases, carbohydrate binding domains, dockerins and cohesins were identified, and it was possible to isolate cultivable fungi and bacteria related to biomass decomposition and with potential applications for the production of biofuels. These results showed that the mangroves possess all fundamental molecular tools required for building the cellulosome, which is required for the efficient degradation of cellulose material and sugar release.

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“…Mangrove plants and their associated microfauna have been a rich source of bioactive molecules [1,2,3], though only limited [4,5,6] antimalarial screening of this chemodiversity source has been reported. Mangrove forests are fascinating and complex ecosystems [7].…”

Section: Introductionmentioning

confidence: 99%

Screening Mangrove Endophytic Fungi for Antimalarial Natural Products

et al. 2013

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We conducted a screening campaign to investigate fungi as a source for new antimalarial compounds. A subset of our fungal collection comprising Chinese mangrove endophytes provided over 5000 lipophilic extracts. We developed an accelerated discovery program based on small-scale cultivation for crude extract screening and a high-throughput malaria assay. Criteria for hits were developed and high priority hits were subjected to scale-up cultivation. Extracts from large scale cultivation were fractionated and these fractions subjected to both in vitro malaria and cytotoxicity screening. Criteria for advancing fractions to purification were developed, including the introduction of a selectivity index and by dereplication of known metabolites. From the Chinese mangrove endophytes, four new compounds (14–16, 18) were isolated including a new dimeric tetrahydroxanthone, dicerandrol D (14), which was found to display the most favorable bioactivity profile.

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Biomolecules Produced by Mangrove-Associated Microbes

Abstract: This review summarizes the sources and characteristics of various natural products that can be extracted from mangrove-associated microbes with a focus on bioactivity, highlighting the unique chemical diversity of these metabolic products.

Cited by 42 publications

References 0 publications

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

Isolation and antimicrobial activities of actinobacteria closely associated with liquorice plants Glycyrrhiza glabra L. and Glycyrrhiza inflate BAT. in Xinjiang, China

A potential source for cellulolytic enzyme discovery and environmental aspects revealed through metagenomics of Brazilian mangroves

Screening Mangrove Endophytic Fungi for Antimalarial Natural Products

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