Biomolecule-functionalized nanoformulations for prostate cancer theranostics

Pranav,; Laskar, Partha; Jaggi, Meena; Chauhan, Subhash C.; Yallapu, Murali M.

doi:10.1016/j.jare.2022.11.001

Cited by 11 publications

(8 citation statements)

References 217 publications

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“…One major disadvantage of biopsies is the possibility of infection by bacteria that is inflaming the patient’s gland [ 44 ]. Furthermore, the course of treatment for PC depends greatly on its stage, and none of these diagnostic techniques can identify PC at the preliminary stage [ 45 ].…”

Section: Diagnosismentioning

confidence: 99%

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

Deshmukh,

Singh,

Harwansh

et al. 2024

Pharmaceutics

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Prostate cancer is one of the most life-threatening disorders that occur in males. It has now become the third most common disease all over the world, and emerging cases and spiking mortality rates are becoming more challenging day by day. Several approaches have been used to treat prostate cancer, including surgery, radiation therapy, chemotherapy, etc. These are painful and invasive ways of treatment. Primarily, chemotherapy has been associated with numerous drawbacks restricting its further application. The majority of prostate cancers have the potential to become castration-resistant. Prostate cancer cells exhibit resistance to chemotherapy, resistance to radiation, ADT (androgen-deprivation therapy) resistance, and immune stiffness as a result of activating tumor-promoting signaling pathways and developing resistance to various treatment modalities. Nanomedicines such as liposomes, nanoparticles, branched dendrimers, carbon nanotubes, and quantum dots are promising disease management techniques in this context. Nanomedicines can target the drugs to the target site and enhance the drug’s action for a prolonged period. They may also increase the solubility and bioavailability of poorly soluble drugs. This review summarizes the current data on nanomedicines for the prevention and treatment of prostate cancer. Thus, nanomedicine is pioneering in disease management.

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Section: Diagnosismentioning

confidence: 99%

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

Deshmukh,

Singh,

Harwansh

et al. 2024

Pharmaceutics

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“…Some polymeric materials applied in cancer therapy include biodegradable polymers such as poly(lactide-co-glycolide) (PLGA), poly(lactic acid) (PLA), poly(caprolactone) (PCL), poly(ethylene glycol) (PEG), and their copolymers [ 48 , 49 ], in addition to polysaccharide-based biopolymers, such as chitosan, sodium alginate, hyaluronic acid, and proteins (such as albumin, gelatin, casein, and elastin) [ 50 , 51 ]. These nanomaterials can still be functionalized for a specific targeted delivery and have been extensively investigated for chemotherapy, immunotherapy, and gene therapy applications [ 52 ].…”

Section: Application Of Nanotechnology Improving the Efficiency Of Po...mentioning

confidence: 99%

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Vieira,

Tessaro,

Lima

et al. 2023

Nutrients

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Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative nanotechnologies have been applied to encapsulate these compounds, aiming to improve their efficacy against cancer. In this comprehensive review, we evaluate the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer using in vitro studies and in vivo preclinical models, highlighting recent advancements in the field. It was found that polymeric nanomaterials, lipid-based nanomaterials, inorganic nanomaterials, and carbon-based nanomaterials are the most used classes of nanocarriers for encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity and pro-apoptotic effects, particularly against breast, lung, prostate, cervical, and colorectal cancer cells, surpassing the performance of free bioactive compounds. Preclinical trials in xenograft animal models have revealed decreased tumor growth after treatment with polyphenol-loaded delivery systems. Moreover, the interaction of polyphenol co-delivery systems and polyphenol–drug delivery systems is a promising approach to increase anticancer activity and decrease chemotherapy side effects. These innovative approaches hold significant implications for the advancement of clinical cancer research.

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“…1 Therefore, recognizing the growing challenges in cancer management, intensive efforts have been dedicated to seamlessly integrating cancer diagnosis and therapy. 2–4 This includes the incorporation of advanced techniques such as photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy, reflecting a flexible approach to address the complexity of cancer treatment. 5,6 Compared with conventional treatments such as radiotherapy, chemotherapy, and clinical surgery, these innovative cancer treatment methods possess visualization and light-induced therapy efficacy.…”

Section: Introductionmentioning

confidence: 99%

UV-assisted synthesis of ultra-small GO–Austar for efficient PTT therapeutic architectonic construction

Gao,

Pei,

Liu

et al. 2024

RSC Adv.

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Biomolecule-functionalized nanoformulations for prostate cancer theranostics

Cited by 11 publications

References 217 publications

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

Emerging Trends of Nanomedicines in the Management of Prostate Cancer: Perspectives and Potential Applications

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

UV-assisted synthesis of ultra-small GO–Austar for efficient PTT therapeutic architectonic construction

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