Biomolecule detection in porous silicon based microcavities<i>via</i>europium luminescence enhancement

Jenie, S. N. Aisyiyah; Du, Zhangli; McInnes, Steven J. P.; Ung, Phuc; Graham, Bim; Plush, Sally E.; Voelcker, Nicolas H.

doi:10.1039/c4tb01409j

Cited by 19 publications

(15 citation statements)

References 44 publications

(58 reference statements)

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“…The resulting 1D photonic structures exhibit a photonic band gap with preventing light reflectance at certain wavelengths. The range of possible 1D pSi photonic crystals include Bragg reflectors, microcavities, and rugate filters 127b. In addition, pSi can be engineered to couple and guide light, rendering resonant structures such as waveguides, resonant rings, and Bloch surface waves …”

Section: Psi‐based Biosensorsmentioning

confidence: 98%

“…In addition, when the product of an enzymatic reaction is the generation or quenching of luminescence, photonic microcavities can be used to enhance this signal and significantly improve the biosensor sensitivity. Recently, Voelcker and his group established a few biosensors focused on the fluorescent enhancement induced by pSi resonant structures . This attribute has been exploited to develop ultra‐sensitive biosensors.…”

Section: Psi‐based Biosensorsmentioning

confidence: 99%

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Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Tieu

Alba

Elnathan

et al. 2018

Advanced Therapeutics

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101

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This review provides a perspective on porous silicon (pSi)-based nanomaterials including nanoparticles, nanowires, and thin films, that are currently being used in advanced therapy, imaging, and sensing, with a focus on their effective use in future clinical settings. The achievement of both controlled geometry and architecture, and surface chemistry motifs, are presented as the two key parameters that dictate the nature of interactions with the biological entities. The authors discuss the role of the degradation kinetics in a biological environment into nontoxic by-products. pSi is presented as increasingly fulfilling a central task in various biomedical applications and clinical settings, owing to its unique physiochemical properties.

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Section: Psi‐based Biosensorsmentioning

confidence: 98%

Section: Psi‐based Biosensorsmentioning

confidence: 99%

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Tieu

Alba

Elnathan

et al. 2018

Advanced Therapeutics

Self Cite

101

View full text Add to dashboard Cite

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“…Porous silicon (PSi)-based nanostructures have been widely reported as potential host matrices for light emitting materials, including organic dyes (Palestino et al, 2008 ; Jenie et al, 2014 , 2015 ; Krismastuti et al, 2014 ; Mo et al, 2017 ) and quantum dots (QDs) (DeLouise Lisa and Ouyang, 2009 ; Qiao et al, 2010 ; Gaur et al, 2011 , 2013 ; Dovzhenko et al, 2015 , 2018a ; Liu et al, 2015 ; Dovzhenko D. S. et al, 2016 ; Li et al, 2017 ; Zhang et al, 2017 ). PSi-based photonic crystals hosts [e.g., Bragg reflector (Liu et al, 2015 ; He et al, 2017 ; Li et al, 2017 ) and microcavities (Jenie et al, 2014 , 2015 )] have been shown to affect the propagation and distribution of the light emitted by the guest fluorophores (Pacholski, 2013 ; Dovzhenko D. et al, 2016 ; Dovzhenko D. S. et al, 2016 ). Specifically, PSi-based microcavities have been shown to improve the spectral properties of emitting molecules, e.g., quantum yield, photostability and luminescence lifetime, by alignment between the reflectance spectrum dip of the microcavity and the emission of the fluorophores (Jenie et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Porous Silicon Bragg Reflector/Carbon Dot Hybrids: Synthesis, Nanostructure, and Optical Properties

2018

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Carbon dots (C-dots) exhibit unique fluorescence properties, mostly depending upon their physical environments. Here we investigate the optical properties and nanostructure of Carbon dots (C-dots) which are synthesized in situ within different porous Silicon (PSi) Bragg reflectors. The resulting hybrids were characterized by photoluminescence, X-ray photoelectron, and Fourier Transform Infrared spectroscopies, as well as by confocal and transmission electron microscopy. We show that by tailoring the location of the PSi Bragg reflector photonic bandgap and its oxidation level, the C-dots emission spectral features can be tuned. Notably, their fluorescence emission can be significantly enhanced when the high reflection band of the PSi host overlaps with the confined C-dots' peak wavelength, and the PSi matrix is thermally oxidized at mild conditions. These phenomena are observed for multiple compositions of PSi Bragg reflectors/C-dots hybrids.

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“…Increasing the rate of mass transport from bulk solution to interface (infiltration rate) is significant for various research areas such as membrane separation, [1][2][3] interfacial chemical reaction, [4][5][6][7][8] thin film fabrication, [9][10][11][12] sensing, [13][14][15] etc. Taking the layer-by-layer assembled multilayer 9,10,[16][17][18][19][20][21] as an example, there is a paradox between increasing the loading amount and enhancing the infiltration rate because the multilayer should grow thick for high loading capacity; 22,23 this results in an increased barrier for infiltration through the multilayer, and thus, a decreased infiltration rate.…”

Section: Introductionmentioning

confidence: 99%

Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers

et al. 2015

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Loading functional small molecules into nano-thin films is fundamental to various research fields such as membrane separation, molecular imprinting, interfacial reaction, drug delivery etc. Currently, a general demand for enhancing the loading rate without affecting the film structures exists in most infiltration phenomena. To handle this issue, we have introduced a process intensification method of a high gravity technique, which is a versatile energy form of mechanical field well-established in industry, into the investigations on diffusion/infiltration at the molecular level. By taking a polyelectrolyte multilayer as a model thin film and a photo-reactive molecule, 4,4'-diazostilbene-2,2'-disulfonic acid disodium salt (DAS), as a model small functional molecule, we have demonstrated remarkably accelerated adsorption/infiltration of DAS into a poly(allylamine hydrochloride) (PAH)/poly(acrylic acid) (PAA) multilayer by as high as 20-fold; meanwhile, both the film property of the multilayer and photoresponsive-crosslinking function of DAS were not disturbed. Furthermore, the infiltration of DAS and the surface morphology of the multilayer could be tuned based on their high dependence on the intensity of the high gravity field regarding different rotating speeds. The mechanism of the accelerated adsorption/infiltration under the high gravity field was interpreted by the increased turbulence of the diffusing layer with the thinned laminar boundary layer and the stepwise delivery of the local concentration gradient from the solution to the interior of the multilayer. The introduction of mechanical field provides a simple and versatile strategy to address the paradox of the contradictory loading amount and loading rate, and thus to promote applications of various membrane processes.

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Biomolecule detection in porous silicon based microcavitiesviaeuropium luminescence enhancement

Abstract: The ability of a porous silicon microcavity (pSiMC) to act as a luminescence enhancing sensor was confirmed using Eu(iii) complex labelled streptavidin as a model analyte on a biotin-modified pSiMC.

Cited by 19 publications

References 44 publications

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Porous Silicon Bragg Reflector/Carbon Dot Hybrids: Synthesis, Nanostructure, and Optical Properties

Introducing a high gravity field to enhance infiltration of small molecules into polyelectrolyte multilayers

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